Abstract: Objective To exlpore the influence of comprehensive rehabilitation therapy on lung function and quality of life in adult patients with bronchial asthma. Methods A total of 116 cases patients with bronchial asthma were divided into two groups randomly. Patients in two groups were given conventional prevention, health education and nursing,on this basis,patients in the observation group were given the comprehensive rehabilitation therapy.The symptom integral day and night,asthma control test (ACT),bronchial asthma quality of life questionnaire (AQLQ) and lung function index:percentage of forced expiratory volume in one second(FEV₁%), and FEV₁/forced vital capacity (FVC) before and after intervention were collected. Results After intervention, the symptom integral of day and night within two groups were significantly lower than before, the ACT score were significantly higher than before the intervention (all P<0.05). AQLQ scores and each dimension score in the observation group were significantly higher after the intervention than before (all P<0.05), and all dimensions showed statistical significance (all P<0.05) except environmental stimulation score in the control group (t=1.206, P=0.233). The difference of FEV1/FVC between groups had a statistical significance (t=2.430, P=0.017). When comparing FEV1/FVC value within each group, the observation group showed statistical significance before and after the intervention (t=2.108, P=0.040). Conclusions Comprehensive rehabilitation therapy can help improve lung function and the quality of life in adult patients with bronchial asthma,and improve the quality of medical care services.