IFITM3基因<i>rs12252</i>位点多态性与中国人群流感易感性: 基于研究的序贯Meta分析

张天琛; 刘晓青; 潘欢弘; 赵玉芹

doi:10.16462/j.cnki.zhjbkz.2019.10.021

IFITM3基因rs12252位点多态性与中国人群流感易感性: 基于研究的序贯Meta分析

doi: 10.16462/j.cnki.zhjbkz.2019.10.021

张天琛^{1, 2},
刘晓青¹,
潘欢弘¹,
赵玉芹^1, ,

1.
330029 南昌, 江西省疾病预防控制中心应急办与急性传染病防制所
2.
102206 北京, 中国疾病预防控制中心传染病预防控制处

基金项目:

江西省卫生计生委科技计划 20156031

详细信息

通讯作者:
赵玉芹, E-mail: 549247578@qq.com

中图分类号: R181.2
计量
- 文章访问数: 359
- HTML全文浏览量: 184
- PDF下载量: 30
- 被引次数: 0
出版历程
- 收稿日期: 2019-04-09
- 修回日期: 2019-06-10
- 刊出日期: 2019-10-10

rs12252 polymorphism of IFITM3 gene and influenza susceptibility in Chinese population: a study-based sequential Meta-analysis

1.
Emergency Office and Acute Infectious Disease Prevention Institute, JiangXi Province Center for Disease Control and Prevention, Nanchang 330029, China
2.
Department of Infectious Diseases Prevention and Control, Chinese Center for Disease Control and Prevention, Beijing 102206, China

Funds:

Science and Technology Plan of jiangxi Provincial Health and Family Planning Commission 20156031

摘要

摘要: 目的系统评价干扰素诱导跨膜蛋白3（interferon-induced transmembrane protein 3，IFITM3）基因rs12252位点多态性与中国人群流感易感性的定量关系。方法检索Medline、PubMed、Embase、Web of Science以及中国知网、万方、维普数据库，收集IFITM3与中国人群流感易感性相关的文章。采用Meta分析方法对收集的文章进行定量地综合分析。结果本次研究共纳入7篇文献，共计919例流感感染的病例，涉及到甲型流感（H7N9、H1N1pmd09、H3N2）及乙型流感病毒，序贯Meta分析显示本研究纳入的研究总样本已达到了得到稳定阳性结局所需的样本量。Meta分析结果发现，IFITM3基因的rs12252多态性与中国人群流感病毒易感性存在关联，携带rs12252 C等位基因的人群更易发生流感（C vs T：OR=1.67，95% CI：1.45~1.92；CC vs TT：OR=2.61，95% CI：1.97~3.46；TC vs TT：OR=1.55，95% CI：1.20~2.00；CC vs TC+TT：OR=2.01，95% CI：1.49~2.72；CC+TC vs TT：OR=8.90，95% CI：4.94~16.06）。结论 IFITM3基因rs12252位点多态性是中国人群发生流感的危险因素。
- IFITM3 /
- rs12252位点多态性 /
- 流感 /
- Meta分析 /
Abstract: Objective To systematically and quantitatively evaluate the relationship of rs12252 polymorphism in IFITM3 gene and susceptibility to influenza in Chinese population. Methods The databases of Medline, PubMed, Embase, Web of Science, China National knowledge infrastructure (CNKI), Wanfang and VIP were searched to retrieve the articles which focused on the topic of relationship between the rs12252 polymorphism and susceptibility to influenza in Chinese population. Meta-analysis method was used to comprehensively and quantitatively analyze the enrolled articles. Results Seven papers with a total of 919 influenza cases were involved in this article. Influenza virus involved influenza A (H7N9, H1N1 pmd09, H3N2) and influenza B. Study-based sequential meta-analysis of the study showed that the total sample size of this study have achieved the required sample size to obtain stable positive results. The results of this meta-analysis showed that the rs12252 polymorphism was associated with susceptibility to influenza in Chinese population and that the rs12252C polymorphism in IFITM3 gene was more susceptible to have influenza in Chinese people (C vs T: OR=1.67, 95% CI: 1.45-1.92; CC vs TT: OR=2.61, 95% CI: 1.97-3.46; TC vs TT: OR=1.55, 95% CI: 1.20-2.00; CC vs TC+TT: OR=2.01, 95% CI: 1.49-2.72; CC+TC vs TT: OR=8.90, 95% CI: 4.94-16.06). Conclusion the rs12252 polymorphism of IFITM3 gene was a risk factor for influenza in Chinese population.
- IFITM3 /
- rs12252 /
- Polymorphism /
- Influenza /
- Meta-analysis

HTML全文

图 1 文献纳入排除流程图

Figure 1. Flowchart of papers inclusion and exclusion

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图 2 等位基因模型(C/T)分析的森林图

Figure 2. Forest plot of allele model analysis (C/T)

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图 3 共显性模型1(CC/TT)分析的森林图

Figure 3. Forest plot of co-dominant model 1 analysis (CC/TT)

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图 4 共显性模型2 (TC/TT) 分析的森林图

Figure 4. Forest plot of co-dominant model 2 analysis (TC/TT)

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图 5 隐性模型(CC/TC+TT) 分析的森林图

Figure 5. Forest plot of recessive model analysis (CC/TC+TT)

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图 6 显性模型(CC+TC/TT) 分析的森林图

Figure 6. Forest plot of dominant model analysis (CC+TC/TT)

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图 7 基于研究的序贯Meta分析结果

Figure 7. Results of study-based sequential Meta-analysis

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表 1 研究纳入文献的基本信息

Table 1. Basic information of the included studies

作者	发表年	研究对象	流感型别	流感病例基因分型			正常人群基因分型
作者	发表年	研究对象	流感型别	TT	TC	CC	TT	TC	CC
Jianbing Zheng^[19]	2016	儿童	未分型	6	25	29	49	98	50
Lee^[10]	2017	成人	H7N9	11	25	15	28	48	29
			H1N1pmd09	51	90	83	28	48	29
Qiaowei Zhu^[20]	2013	儿童	Influenza	6	29	9	73	72	52
Yang Pan^[21]	2016	全年龄组	H3N2	8	45	53	16	34	15
			Yamagata	10	19	24	16	34	15
			H1N1pmd09	3	4	11	16	34	15
YongHong Zhang^[22]	2012	全年龄组	H1N1pmd09	9	39	35	49	98	50
Yongkun Chen^[23]	2017	全年龄组	Influenza B	50	130	84	27	57	19
Zhongfang Wang^[24]	2014	成人	H7N9	3	7	6	24	49	20

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表 2 研究纳入文献的质量评价

Table 2. Quality evaluation of the included studies

研究	研究对象的选择				可比性	暴露的测量
研究	病例定义是否充分	病例的代表性	对照的选择	对照的定义	可比性	暴露的确定	病例和对照组是否采用的相同测量方法	无应答率
Jianbing Zheng^[19]	*		*	*	*	*		*
Lee^[10]	*	*	*	*	*	*		*
Qiaowei Zhu^[20]	*		*	*	*	*		*
Yang Pan^[21]	*	*	*	*	*	*	*	*
YongHong Zhang^[22]	*	*	*	*	**	*	*	*
Yongkun Chen^[23]	*	*	*	*	*	*		*
Zhongfang Wang^[24]	*	*	*	*	*	*		*

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表 3 rs12252基因多态性与中国人群流感易感性的关系(流感组vs正常人群组)

Table 3. Relationship between rs12252 polymorphism and influenza susceptibility in Chinese population (influenza group vs normal group)

病毒亚型	遗传模型	研究数目	OR值(95% CI)	P值	Q值	P_h值	I²值	P_EGGER^a值	统计模型
流感	等位基因模型(C/T)	10	1.67(1.45~1.92)	< 0.001	12.300	0.197	26.83	0.427	固定
流感	共显性模型1 (CC/TT)	10	2.61(1.97~3.46)	< 0.001	11.006	0.275	18.23	0.549	固定
流感	共显性模型2 (TC/TT)	10	1.55(1.20~2.00)	0.001	13.339	0.148	32.53	0.837	固定
流感	隐性模型(CC/TC+TT)	10	2.01(1.49~2.72)	< 0.001	16.751	0.053	46.27	0.567	随机
流感	显性模型(CC+TC/TT)	10	8.9(4.94~16.06)	< 0.001	36.213	<0.001	75.15	0.889	随机
甲型流感	等位基因模型(C/T)	7	1.63(1.37~1.93)	< 0.001	10.146	0.119	40.86	0.547	固定
甲型流感	共显性模型1 (CC/TT)	7	2.44(1.72~3.46)	< 0.001	9.291	0.158	35.42	0.549	固定
甲型流感	共显性模型2 (TC/TT)	7	1.71(1.06~2.76)	0.001	11.053	0.087	45.71	0.771	随机
甲型流感	隐性模型(CC/TC+TT)	7	1.83(1.38~2.30)	0.006	14.358	0.026	58.21	0.642	随机
甲型流感	显性模型(CC+TC/TT)	7	10.45(7.68~14.22)	< 0.001	2.047	0.915	0.00	0.134	固定
乙型流感	等位基因模型(C/T)	2	1.58(1.20~2.08)	0.001	0.251	0.617	0.00	-	固定
乙型流感	共显性模型1 (CC/TT)	2	2.44(1.38~4.30)	0.002	0.012	0.911	0.00	-	固定
乙型流感	共显性模型2 (TC/TT)	2	1.14(0.70~1.85)	0.610	0.314	0.575	0.00	-	固定
乙型流感	隐性模型(CC/TC+TT)	2	2.26(1.43~3.58)	0.001	0.345	0.557	0.00	-	固定
乙型流感	显性模型(CC+TC/TT)	2	0.41(0.00~1027.55)	0.823	28.748	< 0.001	96.52		随机
注：^a文献数少于3篇将不检验发表偏倚。

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