深圳市罗湖区儿童青少年乙型肝炎病毒感染现状

祝方; 廖异; 刘刚; 周小红; 罗毅; 方庆; 刘卫民; 陈国翠; 李笑颜; 程锦泉

doi:10.16462/j.cnki.zhjbkz.2020.10.010

深圳市罗湖区儿童青少年乙型肝炎病毒感染现状

doi: 10.16462/j.cnki.zhjbkz.2020.10.010

祝方^{1, 2},
廖异²,
刘刚²,
周小红²,
罗毅³,
方庆³,
刘卫民⁴,
陈国翠⁴,
李笑颜⁵,
程锦泉^2, ,

1.
518000 深圳, 郑州大学公共卫生学院流行病与卫生统计学教研室
2.
518000 深圳, 深圳市疾病预防与控制中心基层公共卫生促进部
3.
518000 深圳, 罗湖区中医院康复分院体检科
4.
518000 深圳, 罗湖区疾病控制中心传染病防制科
5.
518000 深圳, 中山大学公共卫生学院流行病与卫生统计学教研室

基金项目:

国家“十三五”科技重大专项 2018ZX10715004

中国肝炎防治基金会-中国乙肝防控科研基金资助课题 GYFK20190038

详细信息

通讯作者:
程锦泉, E-mail:cjinquan@szcdc.net

中图分类号: R181
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出版历程
- 收稿日期: 2020-05-06
- 修回日期: 2020-07-14
- 刊出日期: 2020-10-10

Current status of hepatitis B virus infection among children and adolescents in the model area of comprehensive prevention and treatment of hepatitis B in Luohu district in Shenzhen

1.
Department of Epidemiology, College of Public Health, Zhengzhou University, Shenzhen 518000, China
2.
Ministry of Public Health Promotion at the Grass-roots Level, ShenZhen Municipal Center for Disease Control and Prevention, Shenzhen 518000, China
3.
Department of Physical Examination, Luohu Hospital of Traditional Chinese Medicine, Shenzhen 518000, China
4.
Infectious Disease Control Division, Luohu District Center for Disease Control and Prevention, Shenzhen 518000, China
5.
Department of Epidemiology, College of Public Health, Sun Yat-sen University, Shenzhen 518000, China

Funds:

National Scientific and Technological Major Project of China 2018ZX10715004

Hepatitis Prevention and Control Foundation - Project supported by China Hepatitis B prevention and control Research Fund GYFK20190038

More Information

Corresponding author: CHENG Jin-quan,E-mail:cjinquan@szcdc.net

摘要

摘要: 目的了解深圳市罗湖乙肝综合防治示范区（简称罗湖示范区）内儿童青少年乙型肝炎病毒（简称乙肝病毒）感染状况，为开展儿童青少年乙型病毒性肝炎的防制工作提供科学依据。方法采用多阶段整群抽样方法，从罗湖示范区内14所幼儿园、12所小学、2所初中和1所高中共抽取9 599名研究对象。采集静脉血液，采用酶联免疫吸附试验（enzyme linked immunosorbent assay，ELISA）检测血清乙肝病毒标志物。结果乙肝血清标志物阳性率在不同性别间差异无统计学意义；不同学龄组中乙肝表面抗体（hepatitis B surface antigen，抗-HBs）（χ²=196.038，P < 0.001）、乙肝e抗原（hepatitis B virus surface antigen，HBeAg）（χ²=9.925，P=0.019）阳性率具有统计学差异；不同性质的幼儿园幼儿，乙肝血清标志物阳性率差异均无统计学意义；不同性质的小学学生仅乙肝表面抗原（hepatitis B surface antigen，HBsAg）阳性率差异具有统计学意义（χ²=9.487，P=0.002），私立小学阳性率（0.67%）高于公立学校（0.04%）；公立与私立中学学生仅抗-HBs阳性率差异有统计学意义（χ²=25.390，P < 0.001），公立学校（58.85%）高于私立学校（45.43%）。结论罗湖示范区内乙肝综合防治工作卓有成效，未来的工作中，要更加关注高年级学生和外来务工人员子女的乙肝免疫问题。
- 青少年 /
- 儿童 /
- 乙型病毒性肝炎 /
- 免疫效果 /
- 乙肝免疫
Abstract: Objective To investigate the status of hepatitis B virus (HBV) infection among adolescents and children in the model area of comprehensive prevention and treatment of viral hepatitis B in Luohu district in Shenzhen, that provide scientific evidence for the prevention and control of viral hepatitis B. Methods A total of 9 599 subjects were selected from 14 kindergartens, 12 primary schools, 2 middle schools and 1 high school in Luohu demonstration area by multi-stage cluster sampling. Venous blood was collected and serum markers were detected by enzyme linked immunosorbent assay (ELISA). Results There were no statistically significant differences in the positive rate of hepatitis B serum markers between different genders, but there were significant differences in hepatitis B surface antigen (anti-HBs) (χ²=196.038, P < 0.001) and hepatitis B virus surface antigen (HBeAg) (χ²=9.925, P=0.019) among different school age groups. Among different kind of the kindergarten children, serum markers positive rate of hepatitis B were no statistically difference. Only hepatitis B surface antigen positive rate has statistically differences(χ²=9.487, P=0.002) among different primary school students, and the positive rate of private schools were higher (0.67%) than public schools (0.04%). Between public and private middle school students, only the positive of anti-HBs was statistically difference (χ²=25.390, P < 0.001), and public school (58.85%) had higher positive rate than private schools (45.43%). Conclusions The comprehensive prevention and treatment of hepatitis B in the demonstration area is effective. But more attention should be paid to hepatitis B immunization among senior students and children of migrant workers in the future.
- Adolescent /
- Children /
- Viral hepatitis B /
- Immune effect /
- Hepatitis B immunization

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表 1 罗湖乙肝防治示范区儿童青少年乙肝血清标志物水平

Table 1. Serum markers of hepatitis B in children and adolescents in Luohu hepatitis prevention and treatment demonstration area

变量	总数(例)	HBsAg			抗-HBs			HBeAg			抗-HBe			抗-HBc
变量	总数(例)	阳性[n(%)]	χ²值	P值	阳性[n(%)]	χ²值	P值	阳性[n(%)]	χ²值	P值	阳性[n(%)]	χ²值	P值	阳性[n(%)]	χ²值	P值
性别			0.963	0.326		3.085	0.079		0.369	0.544		0.001	0.974		1.349	0.245
男	5 188	10(0.19)			3 457(66.64)			12(0.23)			6(0.12)			14(0.27)
女	4 411	5(0.11)			2 864(64.93)			13(0.30)			5(0.11)			7(0.16)
学龄组			3.338^a	0.342		196.038	＜0.001		9.925^a	0.019		4.825^a	0.185		6.954^a	0.073
幼儿园	3 869	3(0.08)			2 554(66.01)			3(0.08)			3(0.08)			4(0.10)
小学	3 359	8(0.24)			2 415(71.90)			13(0.39)			2(0.06)			13(0.39)
初一	1 436	2(0.14)			732(50.98)			5(0.35)			3(0.21)			2(0.14)
高一	935	2(0.21)			620(66.31)			4(0.43)			3(0.32)			2(0.21)
注：^a该数值为校正后的χ²值。

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表 2 不同性质学校青少年儿童乙肝血清标志物阳性水平

Table 2. Positive levels of serum markers of hepatitis B in adolescents and children from different schools

变量	总数(例)	HBsAg			抗-HBs			HBeAg			抗-HBe			抗-HBc
变量	总数(例)	阳性[n(%)]	χ²值	P值	阳性[n(%)]	χ²值	P值	阳性[n(%)]	χ²值	P值	阳性[n(%)]	χ²值	P值	阳性[n(%)]	χ²值	P值
幼儿园			-^a	-^a		2.065	0.151		0.113^b	0.738		-^a	-^a		0.336^b	0.562
公立	969	0(0.00)			658(67.91)			0(0.00)			0(0.00)			0(0.00)
私立	2 900	3(0.10)			1 896(65.38)			3(0.10)			3(0.10)			4(0.14)
小学			9.487^b	0.002		1.704	0.192		2.213^b	0.137		-^a	-^a		0.786^b	0.375
公立	2 319	1(0.04)			1 683(72.57)			6(0.26)			1(0.04)			7(0.30)
私立	1 040	7(0.67)			732(70.39)			7(0.67)			1(0.10)			6(0.58)
初中			-^a	-^a		50.499	＜0.001		0.157^b	0.692		-^c	-^c		-^a	-^a
公立	843	1(0.12)			496(58.84)			2(0.24)			2(0.24)			1(0.12)
私立	593	1(0.17)			236(39.79)			3(0.51)			1(0.17)			1(0.17)
注：^a该处数据由于理论频数小于1，使用Fisher确切概率法，所得结果均无统计学意义；^b此数值为校正后的卡方值；^c由于阳性样本过少，此处不进行比较。

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变量	总数(例)	HBsAg			抗-HBs			HBeAg			抗-HBe			抗-HBc
变量	总数(例)	阳性[n(%)]	χ²值	P值	阳性[n(%)]	χ²值	P值	阳性[n(%)]	χ²值	P值	阳性[n(%)]	χ²值	P值	阳性[n(%)]	χ²值	P值
性别			0.963	0.326		3.085	0.079		0.369	0.544		0.001	0.974		1.349	0.245
男	5 188	10(0.19)			3 457(66.64)			12(0.23)			6(0.12)			14(0.27)
女	4 411	5(0.11)			2 864(64.93)			13(0.30)			5(0.11)			7(0.16)
学龄组			3.338^a	0.342		196.038	＜0.001		9.925^a	0.019		4.825^a	0.185		6.954^a	0.073
幼儿园	3 869	3(0.08)			2 554(66.01)			3(0.08)			3(0.08)			4(0.10)
小学	3 359	8(0.24)			2 415(71.90)			13(0.39)			2(0.06)			13(0.39)
初一	1 436	2(0.14)			732(50.98)			5(0.35)			3(0.21)			2(0.14)
高一	935	2(0.21)			620(66.31)			4(0.43)			3(0.32)			2(0.21)
注：^a该数值为校正后的χ²值。

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深圳市罗湖区儿童青少年乙型肝炎病毒感染现状

doi: 10.16462/j.cnki.zhjbkz.2020.10.010

通讯作者:
程锦泉, E-mail:cjinquan@szcdc.net

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Current status of hepatitis B virus infection among children and adolescents in the model area of comprehensive prevention and treatment of hepatitis B in Luohu district in Shenzhen

Corresponding author: CHENG Jin-quan,E-mail:cjinquan@szcdc.net

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深圳市罗湖区儿童青少年乙型肝炎病毒感染现状

doi: 10.16462/j.cnki.zhjbkz.2020.10.010

通讯作者: 程锦泉, E-mail:cjinquan@szcdc.net

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出版历程

Current status of hepatitis B virus infection among children and adolescents in the model area of comprehensive prevention and treatment of hepatitis B in Luohu district in Shenzhen

Corresponding author: CHENG Jin-quan,E-mail:cjinquan@szcdc.net

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出版历程

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通讯作者:
程锦泉, E-mail:cjinquan@szcdc.net