低出生体重儿婴儿期体格生长指标参考值偏度系数-中位数-变异系数法研究

邵子瑜; 孙瑜; 李培培; 卫华章; 段毓雯; 李玲; 王红新; 许修琴

doi:10.16462/j.cnki.zhjbkz.2020.10.017

低出生体重儿婴儿期体格生长指标参考值偏度系数-中位数-变异系数法研究

doi: 10.16462/j.cnki.zhjbkz.2020.10.017

1.
230001 合肥, 合肥市妇幼保健计划生育服务中心
2.
230011 合肥, 包河区妇幼保健计划生育服务中心
3.
230011 合肥, 蜀山区妇幼保健计划生育服务中心
4.
230042 合肥, 瑶海区妇幼保健计划生育服务中心
5.
230001 合肥, 庐阳区妇幼保健计划生育服务中心

基金项目:

中国疾病预防控制中心妇幼保健中心合生元母婴营养与健康研究项目 2012FY016

详细信息

通讯作者:
邵子瑜, E-mail:shaoziyu88@163.com

中图分类号: R181
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- 被引次数: 0
出版历程
- 收稿日期: 2019-12-31
- 修回日期: 2020-06-01
- 刊出日期: 2020-10-10

Lambda-mu-sigma method(LMS) study on the physical growth reference standard of low birth weight infant

1.
Maternal and Child Health and Family Planning Service Center, Hefei 230011, China
2.
Maternal and Child Health and Family Planning Service Center of Baohe District, Hefei 230011, China
3.
Shushan District Maternal and Child Health and Family Planning Service Center, Hefei 230042, China
4.
Yaohai Maternal and Child Health and Family Planning Service Center, Hefei 230001, China
5.
Luyang District Maternal and Child Health and Family Planning Service Center, Hefei 230001, China

Funds:

Heshengyuan Maternal and Child Nutrition and Health Research Project of National Center for Women and Children's Health, China CDC 2012FY016

More Information

Corresponding author: SHAO Zi-yu, E-mail:shaoziyu88@163.com

摘要

摘要: 目的了解合肥市主城区低出生体重儿（low birth weight infant，LBWI）0~12月体格生长状况，掌握合肥市早产低出生体重儿和足月小样儿婴儿期生长轨迹。方法建立出生队列，228名LBWI进入队列，选取同期同机构接受健康管理的161名正常出生体重儿（normal birth weight infant，NBWI）作为对照组，监测婴儿0~12月龄体格生长指标，以偏度系数-中位数-变异系数（lambda-mu-sigma，LMS）法计算性别年龄别体重、身长各百分位数值，并绘制LMS曲线。结果婴儿期LBWI组体重、身长等指标均明显低于NBWI组，差异有统计学意义（均有P < 0.001）；LBWI 3月龄体重达到出生时2.5倍，12月龄体重约为出生时4.3倍，12月龄身长为出生时1.6倍；总体上LBWI组在生后第1年尤其在6月龄前体重、身长呈追赶生长趋势，早产低出生体重儿追赶生长速度快于足月小样儿。结论 LBWI在婴儿期存在追赶生长，LMS法建立的合肥市早产低出生体重儿与足月小样儿婴儿期生长曲线客观地描述了两者不同的体格生长特点和轨迹。
- 低出生体重 /
- 婴儿 /
- 生长标准 /
- LMS法
Abstract: Objective To investigate the physical growth status of low birth-weight infants (LBWI) from 0 to 12 months in main urban area of Hefei City, so as to obtain the growth trajectory of premature low birth-weight infants and mature low birth-weight infants in Hefei. Methods A birth cohort was established, totally 228 LBWI entered the cohort, 161 normal birth weight infant (NBWI) from the same center were selected as control group. The physical growth indicators were monitored during 0-12 months, the percentile values of weight and length for age and gender were calculate by using lambda-mu-sigma(LMS) method, and LMS curves were drew. Results The body weight and length of LBWI group were significantly lower than those of NBWI group during the infancy stage, and the difference was statistically significant (all P < 0.001). The weight of LBWI was 2.5 times heavier at 3 months than at birth, 4.3 times heavier at 12 months than at birth, and the length of LBWI was 1.6 times longer at 12 months than at birth.In general, the LBWI group showed a catch-up growth trend on weight and length in the first year, especially under 6 months. The catch-up growth rate of premature low-birth-weight infants was faster than that of mature low birth-weight infants. Conclusions There is catch-up growth of LBWI during 0-12 months. The growth curves by LMS method of premature low birth weight infants and mature low birth-weight infants can objectively describe their different physical growth characteristics and trajectories.
- Low birth weight /
- Infant /
- Growth standards /
- LMS method

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图 1 早产低出生体重儿、足月小样儿和正常出生体重儿男婴0~12月体重百分位数曲线

Figure 1. Percentile curve of the weight of premature LBWI, mature LBWI and NBWI for male infants aged from 0 to 12 months

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图 2 早产低出生体重儿、足月小样儿和正常出生体重儿女婴0~12月体重百分位数曲线

Figure 2. Percentile curve of the weight of premature LBWI, mature LBWI and NBWI for female infants aged from 0 to 12 months

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图 3 早产低出生体重儿、足月小样儿和正常出生体重儿男婴0~12月身长百分位数曲线

Figure 3. Percentile curve of the length of premature LBWI, mature LBWI and NBWI for male infants aged from 0 to 12 months

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图 4 早产低出生体重儿、足月小样儿和正常出生体重儿女婴0~12月身长百分位数曲线

Figure 4. Percentile curve of the length of premature LBWI, mature LBWI and NBWI for female infants aged from 0 to 12 months

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表 1 LBWI组与NBWI组一般人口学特征[n(%)]

Table 1. Characteristics of LBWI and NBWI[n(%)]

因素	LBWI组	NBWI组	χ²/t值	P值
性别			0.026	0.873
男	110(48.25)	79(49.07)
女	118(51.75)	82(50.93)
母亲年龄(岁)			5.534	0.019
＜35	205(89.91)	155(96.27)
≥35	23(10.09)	6(3.73)
母亲文化程度			5.289	0.071
初中及以下	32(14.03)	12(7.45)
高中	45(19.74)	27(16.77)
大专及以上	151(66.23)	122(75.78)
分娩方式			0.116	0.734
自然分娩	98(42.98)	72(44.72)
剖腹产	130(57.02)	89(55.28)
出生胎龄[月, (x±s)]	35.68±2.69	39.77±0.90	18.571	＜0.001
出生体重[g, (x±s)]	2 138±306	3 375±340	37.765	＜0.001
身长[cm, (x±s)]	45.53±3.04	50.39±1.26	19.109	＜0.001

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表 2 LBWI组与NBWI组男婴体格发育指标比较(x±s)

Table 2. Comparison of physical growth indexes of male infants between LBWI and NBWI (x±s)

月龄	LBWI		NBWI		t1值	P值	t2值	P值
月龄	体重(kg)	身长(cm)	体重(kg)	身长(cm)	t1值	P值	t2值	P值
0	2.17±0.27	45.8±2.8	3.43±0.27	50.5±1.2	29.833	＜0.001	15.700	＜0.001
1	3.56±0.58	51.3±2.4	4.86±0.52	56.1±1.7	14.371	＜0.001	13.706	＜0.001
2	4.59±0.63	54.8±2.2	6.03±0.68	59.9±2.2	11.992	＜0.001	10.616	＜0.001
3	5.70±0.73	58.7±2.2	7.06±0.73	63.2±1.9	12.514	＜0.001	13.436	＜0.001
4	6.59±0.80	61.9±2.2	7.88±0.73	65.8±1.9	10.065	＜0.001	11.340	＜0.001
5	7.12±0.79	64.3±2.1	8.53±0.79	68.4±1.7	10.169	＜0.001	12.482	＜0.001
6	7.65±0.83	66.4±2.1	8.73±0.78	69.8±1.9	9.204	＜0.001	11.585	＜0.001
7	7.96±0.88	68.3±2.4	9.28±0.88	71.5±1.9	7.332	＜0.001	7.805	＜0.001
8	8.34±0.88	69.6±2.1	9.75±0.99	73.2±2.0	7.570	＜0.001	8.696	＜0.001
9	8.75±0.91	71.1±2.2	9.91±0.98	74.4±2.2	7.956	＜0.001	9.837	＜0.001
10	9.18±1.20	72.4±2.5	10.14±0.99	75.3±2.2	4.545	＜0.001	6.595	＜0.001
11	9.42±1.11	73.8±2.5	10.34±0.89	76.6±1.6	4.255	＜0.001	5.891	＜0.001
12	9.52±0.97	75.0±2.3	10.69±1.07	77.9±2.3	7.421	＜0.001	8.125	＜0.001
注：t1表示两组体重比较，t2表示两组身长比较。

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表 3 LBWI组与NBWI组女婴体格发育指标比较(x±s)

Table 3. Comparison of physical growth indexes of female infants between LBWI and NBWI (x±s)

月龄	LBWI		NBWI		t1值	P值	t2值	P值
月龄	体重(kg)	身长(cm)	体重(kg)	身长(cm)	t1值	P值	t2值	P值
0	2.11±0.34	45.5±3.0	3.33±0.37	50.2±1.7	24.476	＜0.001	13.371	＜0.001
1	3.39±0.59	50.3±2.7	4.63±0.52	55.6±1.7	12.690	＜0.001	13.805	＜0.001
2	4.41±0.65	54.4±2.7	5.60±0.67	58.9±1.9	10.774	＜0.001	11.392	＜0.001
3	5.35±0.75	57.7±2.8	6.44±0.78	62.0±1.7	9.497	＜0.001	13.157	＜0.001
4	6.07±0.75	60.4±2.4	6.97±0.91	64.0±2.0	6.437	＜0.001	9.365	＜0.001
5	6.65±0.73	62.7±2.2	7.55±0.89	66.1±1.8	6.339	＜0.001	9.714	＜0.001
6	7.22±0.89	65.0±2.6	8.05±1.00	67.9±1.9	6.247	＜0.001	8.274	＜0.001
7	7.48±0.86	66.4±2.4	8.13±0.83	69.3±1.8	4.152	＜0.001	7.410	＜0.001
8	7.91±0.85	68.4±2.5	8.67±0.94	71.0±2.0	4.552	＜0.001	6.329	＜0.001
9	8.37±0.92	70.1±2.6	8.95±1.00	72.5±1.9	4.051	＜0.001	6.666	＜0.001
10	8.70±0.90	71.7±2.6	9.21±1.00	73.9±2.3	2.553	0.012	4.300	＜0.001
11	9.00±1.10	72.9±2.6	9.59±0.91	75.4±1.8	2.575	0.012	4.753	＜0.001
12	9.13±0.98	74.1±2.5	9.69±1.00	76.2±2.1	3.834	＜0.001	6.102	＜0.001
注：t1表示两组体重比较，t2表示两组身长比较。

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表 4 足月小样儿组与早产低出生体重组男婴体格生长指标比较(x±s)

Table 4. Comparison of physical growth indexes of male infants between mature LBWI and premature LBWI (x±s)

月龄	足月小样儿组		早产低出生体重组		t1值	P值	t2值	P值
月龄	体重(kg)	身长(cm)	体重(kg)	身长(cm)	t1值	P值	t2值	P值
0	2.25±0.20	45.5±3.0	2.04±0.34	50.2±1.7	3.072	0.003	2.424	0.027
1	3.69±0.53	51.7±2.3	4.63±0.52	50.3±2.9	2.499	0.014	2.435	0.017
2	4.81±0.54	56.0±1.9	4.50±0.67	53.5±3.5	2.107	0.039	3.705	＜0.001
3	5.83±0.70	59.5±2.3	5.63±0.75	58.2±2.1	1.317	0.191	2.833	0.006
4	6.62±0.86	62.8±2.1	6.59±0.75	61.5±2.1	0.199	0.843	2.683	0.009
5	7.04±0.87	64.4±2.2	7.17±0.75	64.1±2.0	0.663	0.509	0.584	0.561
6	7.47±0.85	66.3±2.2	7.76±0.81	66.4±2.0	1.771	0.079	0.199	0.843
7	7.52±0.64	67.8±1.7	8.17±0.94	68.5±2.6	2.673	0.010	1.142	0.258
8	8.11±0.73	69.7±1.9	8.58±0.90	69.6±2.4	2.044	0.046	0.021	0.983
9	8.46±0.92	70.7±2.2	8.93±0.88	71.3±2.1	2.529	0.013	1.244	0.216
10	8.77±1.12	72.1±2.8	9.39±1.19	72.5±2.3	1.986	0.052	0.678	0.500
11	8.61±1.04	73.3±3.1	9.68±1.01	74.0±2.4	3.174	0.003	0.804	0.425
12	9.19±0.94	74.8±2.4	9.74±0.93	75.2±2.3	2.858	0.005	0.761	0.449
注：t1表示两组体重比较，t2表示两组身长比较。

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表 5 足月小样儿组与早产低出生体重组女婴体格生长指标比较(x±s)

Table 5. Comparison of physical growth indexes of female infants between mature LBWI and premature LBWI (x±s)

月龄	足月小样儿组		早产低出生体重组		t1值	P值	t2值	P值
月龄	体重(kg)	身长(cm)	体重(kg)	身长(cm)	t1值	P值	t2值	P值
0	2.25±0.21	46.5±2.3	1.97±0.38	44.2±3.4	5.081	＜0.001	4.316	＜0.001
1	3.62±0.56	51.4±2.6	3.23±0.68	49.7±3.0	2.970	0.004	2.908	0.005
2	4.57±0.59	55.2±2.3	4.25±0.68	53.6±2.9	2.398	0.019	2.880	0.005
3	5.53±0.67	58.4±2.3	5.19±0.82	56.9±3.1	2.448	0.016	2.971	0.004
4	6.21±0.67	61.2±2.0	5.94±0.81	59.8±2.6	1.725	0.088	2.824	0.006
5	6.60±0.56	63.1±1.7	6.70±0.87	62.3±2.6	0.600	0.550	1.626	0.108
6	7.23±0.89	65.5±2.7	7.20±0.99	64.5±2.5	0.142	0.887	2.061	0.042
7	7.25±0.86	66.1±2.2	7.63±0.99	66.7±2.5	1.710	0.092	0.862	0.392
8	7.79±0.66	68.6±2.3	8.04±1.00	68.3±2.7	1.145	0.257	0.465	0.644
9	8.32±0.88	70.1±2.7	8.42±0.97	70.1±2.6	0.620	0.536	0.025	0.980
10	8.35±0.76	71.2±2.5	9.06±0.89	72.1±2.7	2.851	0.007	1.194	0.239
11	8.74±0.87	72.8±2.4	9.24±1.25	73.0±2.9	1.476	0.148	0.268	0.790
12	9.05±0.92	74.1±2.5	9.21±1.04	74.1±2.6	0.867	0.388	0.043	0.966
注：t1表示两组体重比较，t2表示两组身长比较。

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