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艾滋病与结核病双重感染的研究进展

厉虹淼 唐飞 陈双双 张根友 吕莉萍 史四九 范引光

厉虹淼, 唐飞, 陈双双, 张根友, 吕莉萍, 史四九, 范引光. 艾滋病与结核病双重感染的研究进展[J]. 中华疾病控制杂志, 2020, 24(12): 1459-1464. doi: 10.16462/j.cnki.zhjbkz.2020.12.018
引用本文: 厉虹淼, 唐飞, 陈双双, 张根友, 吕莉萍, 史四九, 范引光. 艾滋病与结核病双重感染的研究进展[J]. 中华疾病控制杂志, 2020, 24(12): 1459-1464. doi: 10.16462/j.cnki.zhjbkz.2020.12.018
LI Hong-miao, TANG Fei, CHEN Shuang-shuang, ZHANG Gen-you, LYU Li-ping, SHI Si-jiu, FAN Yin-guang. Research progress of co-infection of acquired immune deficiency syndrome and tuberculosis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(12): 1459-1464. doi: 10.16462/j.cnki.zhjbkz.2020.12.018
Citation: LI Hong-miao, TANG Fei, CHEN Shuang-shuang, ZHANG Gen-you, LYU Li-ping, SHI Si-jiu, FAN Yin-guang. Research progress of co-infection of acquired immune deficiency syndrome and tuberculosis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(12): 1459-1464. doi: 10.16462/j.cnki.zhjbkz.2020.12.018

艾滋病与结核病双重感染的研究进展

doi: 10.16462/j.cnki.zhjbkz.2020.12.018
厉虹淼和唐飞为共同第一作者.
基金项目: 

国家科技重大专项 2018ZX10302302-003-003

国家自然科学基金 82003515

安徽省自然科学基金 1908085QH368

中国疾病预防控制中心柳州市艾滋病技术支持项目 K2020043

详细信息
    通讯作者:

    史四九, E-mail:461912623@qq.com

    范引光, E-mail:fanyinguang@163.com

  • 中图分类号: R512.91;R521

Research progress of co-infection of acquired immune deficiency syndrome and tuberculosis

LI Hong-miao and TANG Fei contribute equally to the article.
Funds: 

National Major Science and Technology Projects of China 2018ZX10302302-003-003

National Natural Science Foundation of China 82003515

Anhui Provincial Natural Science Foundation 1908085QH368

Program of technical support for Liuzhou City authorized by the Chinese National Center for AIDS/STD Control and Prevention K2020043

More Information
  • 摘要: 艾滋病(acquired immune deficiency syndrome, AIDS)与结核病(tuberculosis, TB)双重感染可加快患者的病情进展,使患者各器官功能迅速衰竭,最终导致死亡。AIDS合并TB的防治不仅是临床面临的一大难题,也已成为全球范围内一个重大公共卫生问题。本文从AIDS/TB双重感染的流行现状、发病机制、临床特征、诊断方法、治疗方案及预防措施等角度出发,对这一重大公共卫生问题的研究现状进行综述,为制定降低AIDS与TB双重感染的措施提供科学依据。
  • [1] 联合国艾滋病规划署. 2020全球艾滋病防治进展报告[EB/OL]. (2020-07-20)[2020-10-30].http://www.unaids.org.cn/page122?article_id=1200.

    The Joint United Nations Programme on HIV/AIDS. Global AIDS progress report 2020[EB/OL]. (2020-07-20)[2020-10-30].http://www.unaids.org.cn/page122?article_id=1200.
    [2] 谢祎, 孙昕.结核病与艾滋病双重感染的流行现状与研究进展[J].中华医院感染学杂志, 2019, 29(19), 3036-3040. DOI: 10.11816/cn.ni.2019-182959.

    Xie Y, Sun X. Epidemiological status and research progress of co-infection of Mycobacterium tuberculosis and human[J]. Chin J Nosocomiol, 2019, 29(19):3036-3040. DOI: 10.11816/cn.ni.2019-182959.
    [3] 国家卫生健康委疾病预防控制局. 2019年全国法定传染病疫情概况[J].中国病毒病杂志, 2020, 10(4):245. http://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&filename=NKYT201901019

    Bureau of Disease Prevention and Control, National Health Commission. A brief overview of the notifiable infectious diseases in 2019[J]. Chin J Viral Dis, 2020, 10(4):245. http://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&filename=NKYT201901019
    [4] 李乐, 周子豪, 吴群红, 等. HIV感染者/AIDS患者中结核病检出率的meta分析[J].职业与健康, 2019, 35(24):3437-3441. DOI: 10.13329/j.cnki.zyyjk.2019.0918.

    Li L, Zhou ZH, Wu QH, et al. A meta-analysis of tuberculosis detection rate in HIV/AIDS patients[J]. Occup and Health, 2019, 35(24):3437-3441. DOI: 10.13329/j.cnki.zyyjk.2019.0918.
    [5] >World Health Organization. Global tuberculosis report 2019[EB/OL]. (2020-10-14)[2020-10-24].https://apps.who.int/iris/bitstream/handle/10665/336069/9789240013131-eng.pdf.
    [6] Getahun H, Gunneberg C, Granich R, et al. HIV infection-associated tuberculosis: the epidemiology and the response[J]. Clin Infect Dis, 2010, 50(suppl 3):S201-207.DOI: 10.1086/651492.
    [7] Sonnenberg P, Glynn JR, Fielding K, et al. How soon after infection with HIV does the risk of tuberculosis start to increase? A etrospective cohort study in South African gold miners[J]. J Infect Dis, 2005, 191(2):150-158. DOI: 10.1086/426827.
    [8] Wolf AJ, Linas B, Trevejo-Nunez GJ, et al. Mycobacterium tuberculosis infects dendritic cells with high frequency and impairs their function in vivo[J]. J Immunol, 2007, 179(4):2509-2519. DOI: 10.4049/jimmunol.179.4.2509.
    [9] Egen JG, Rothfuchs AG, Feng CG, et al. Intravital imaging reveals limited antigen presentation and T cell effector function in mycobacterial granulomas[J]. Immunity, 2011, 34(5):807-19. DOI: 10.1016/j.immuni.2011.03.022.
    [10] Reece ST, Kaufmann SH. Floating between the poles of pathology and protection: can we pin down the granuloma in tuberculosis?[J]. Curr Opin Microbiol, 2012, 15(1):63-70. DOI: 10.1016/j.mib.2011.10.006.
    [11] Christof G, Alimuddin Z, Michael H. Interaction between HIV and Mycobacterium tuberculosis: HIV-1-induced CD4 T-cell depletion and the development of active tuberculosis[J]. Curr Opin HIV AIDS, 2012, 7(3):268-275. DOI: 10.1097/COH.0b013e3283524e32.
    [12] Björn C, Allison NB, Maud D, et al. HIV-1 and SIV infection are associated with early loss of lung interstitial CD4+ T cells and dissemination of pulmonary tuberculosis[J]. Cell Reports, 2019, 26(6):1409-1418. DOI: 10.1016/j.celrep.2019.01.021.
    [13] Nada P, Panadda D, Shinsaku S, et al. Coordinated in vitro release of granulysin, perforin and IFN- in TB and HIV/TB co-infection associated with clinical outcomes before and after anti-TB treatment[J]. Pathogens, 2020, 14, 9(8):655. DOI: 10.3390/pathogens9080655.
    [14] Nada P, Shinsaku S, Takahiro T, et al. Potential function of granulysin, other related effector molecules and lymphocyte subsets in patients with TB and HIV/TB coinfection[J]. Int J Med Sci, 2013, 10(8):1003-1014. DOI: 10.7150/ijms.6437.
    [15] Marcela MT, Jôsimar DM, Fernanda FCN, et al. Evaluation of profile and functionality of memory T cells in pulmonary tuberculosis[J]. Immunol Lett, 2017, 192:52-60. DOI: 10.1016/j.imlet.2017.10.014.
    [16] Ramana Rao PV, Rajasekaran S, Raja A. Natural killer cell-mediated cytokine response among HIV-positive south Indians with pulmonary tuberculosis[J]. J Interferon Cytokine Res, 2010, 30(1):33-42. DOI: 10.1089/jir.2009.0018.
    [17] Raghavan S, Alagarasu K, Selvaraj P. Immunogenetics of HIV and HIV associated tuberculosis[J]. Tuberculosis (Edinb), 2012, 92(1):18-30. DOI: 10.1016/j.tube.2011.08.004.
    [18] Esther van W, Edward BI, Leela D, et al. HIV is associated with modified humoral immune responses in the setting of HIV/TB coinfection[J]. mSphere, 2020, 5(3):e00104-20. DOI: 10.1128/mSphere.00104-20.
    [19] 阮军, 尹恒, 寇国先, 等.艾滋病合并肺结核259例临床分析[J].中国艾滋病性病, 2020, 26(5):490-492. DOI: 10.13419/j.cnki.aids.2020.05.09.

    Ruan J, Yin H, Kou GX, et al. Clinical analysis of 259 cases of AIDS complicated with pulmonary tuberculosis[J]. Chin J AIDS STD, 2020, 26(5):490-492. DOI: 10.13419/j.cnki.aids.2020.05.09.
    [20] Fausto C, Francesca L, Roberto L, et al. Hematologic alterations and early mortality in a cohort of HIV positive African patients[J]. PloS One, 2020, 15(11): e0242068. DOI: 10.1371/journal.pone.0242068.
    [21] 葛晓飞, 任彦微, 陈宇飞, 等.艾滋病合并肺结核临床特点分析[J].中国现代药物应用, 2020, 14(1):41-42. DOI: 10.14164/j.cnki.cn11-5581/r.2020.01.019.

    Ge XF, Ren YW, Chen YF, et al. Analysis of clinical characteristics of AIDS complicated with tuberculosis[J]. Chin J Mod Drug, 2020, 14(1):41-42. DOI: 10.14164/j.cnki.cn11-5581/r.2020.01.019.
    [22] 曹世敏, 胡丽华.艾滋病合并肺结核临床特点及其治疗[J].中外医疗, 2018, 37(12):31-33. DOI: 10.16662/j.cnki.1674-0742.2018.12.031.

    Cao SM, Hu LH. Clinical characteristics and treatment of AIDS combined with pulmonary tuberculosis[J]. China & Foreign Medical Treatment, 2018, 37(12):31-33. DOI: 10.16662/j.cnki.1674-0742.2018.12.031.
    [23] 敬苑霖.艾滋病合并肺结核的临床诊断相关研究[J].世界最新医学信息文摘, 2018, 18(2):63-64. DOI: 10.19613/j.cnki.1671-3141.2018.02.044.

    Jing YL. Study on the clinical diagnosis of AIDS complicated with tuberculosis[J]. World Latest Medicne Information, 2018, 18(2):63-64. DOI: 10.19613/j.cnki.1671-3141.2018.02.044
    [24] 张林, 王永素, 苗瑞红, 等.艾滋病合并肺结核病患者综合特征分析[J].临床肺科杂志, 2019, 24(12):2227-2230. DOI: 10.3969/j.issn.1009-6663.2019.12.021.

    Zhang L, Wang YS, Miao RH, et al. Comprehensive characteristics analysis of HIV/TB patients[J]. Journal of Clinical Pulmonary Medicine, 2019, 24(12):2227-2230. DOI: 10.3969/j.issn.1009-6663.2019.12.021.
    [25] 张彦, 胡国启, 司丽, 等.艾滋病合并肺结核与单纯肺结核患者的临床特点对比分析研究[J].传染病信息, 2018, 31(6):552-554. DOI: 10.3969/j.issn.1007-8134.2018.06.014

    Zhang Y, Hu GQ, Si L, et al. A comparative study on clinical characteristics of AIDS patients with pulmonary tuberculosis and sim[J]. Infect Dis Info, 2018, 31(6):552-554. DOI: 10.3969/j.issn.1007-8134.2018.06.014.
    [26] 李春华, 刘雪艳, 吕圣秀, 等.艾滋病并发血行播散性肺结核的临床及CT表现分析[J].中国艾滋病性病, 2019, 25(11):1101-1104. DOI: 10.13419/j.cnki.aids.2019.11.02

    Li CH, Liu XY, Lv SX, et al. Analysis of clinical and CT manifestations of AIDS with concurrent hematogenous disseminated pulmona[J] Chin J AIDS STD, 2019, 25(11):1101-1104. DOI: 10.13419/j.cnki.aids.2019.11.02
    [27] 许禹. 80例艾滋病合并肺结核患者胸部CT影像学特征研究[J].皮肤病与性病, 2019, 41(2):198-200. DOI: 10.3969/j.issn.1002-1310.2019.02.017.

    Xun Y. Chest CT imaging characteristics of 80 AIDS patients with pulmonary tuberculosis[J]. J Dermatology and Venereology, 2019, 41(2):198-200. DOI: 10.3969/j.issn.1002-1310.2019.02.017.
    [28] 孔令周, 王京华.艾滋病合并肺结核的CT影像学诊断[J].现代医用影像学, 2020, 29(3):507-508. http://med.wanfangdata.com.cn/Paper/Detail?id=PeriodicalPaper_xdyyyxx202003037

    Sun LZ, Wang JH. CT imaging diagnosis of AIDS complicated with pulmonary tuberculosis[J]. Modern Med Imagel Bimonthly, 2020, 29(3):507-508. http://med.wanfangdata.com.cn/Paper/Detail?id=PeriodicalPaper_xdyyyxx202003037
    [29] 中华医学会感染病学分会艾滋病丙型肝炎学组, 中国疾病预防控制中心.中国艾滋病诊疗指南(2018版)[J].新发传染病电子杂志, 2019, 4(2):65-84. http://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&filename=CRBX201901004

    AIDS and Hepatitis C Professional Group, Society of Infectious Diseases, Chinese Medical Association, Chinese Center for Disease Control and Prevention. Chinese guidelines for diagnosis and treatment of HIV/AIDS (2018 edition)[J]. Electronic Journal of Emerging Infectious Diseases, 2019, 4(2):65-84. http://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&filename=CRBX201901004
    [30] 边泽源, 杨云红, 吴芝炜, 等. γ干扰素释放试验在HIV合并TB感染中的应用价值[J].实验与检验医学, 2019, 37(6):1012-1014. DOI: 10.3969/j.issn.1674-1129.2019.06.008.

    Bian ZY, Yang YB, Wu ZW, et al. The application value of γ-interferon release test in HIV combined with tuberculosis infection[J]. Experimental and Laboratory Medicine, 2019, 37(6):1012-1014. DOI: 10.3969/j.issn.1674-1129.2019.06.008.
    [31] Liang Y, Wang Y, Li H, et al. Evalution of a wholeblood chemi-luminescent immunoassay of IFN-γ, IP-10, and MCP-1 fordiagno-sis of active pulmonary tuberculosis and tuberculous pleurisy pa-tients[J]. APMIS, 2016, 124(10):856-864. DOI: 10.1111/apm.12583.
    [32] Huo ZY, Peng L. Accuracy of the interferon-gamma release assay for the diagnosis of active tuberculosis among HIVseropositive individuals: a systematic review and meta-analysis[J]. BMC Infect Dis, 2016, 16:350. DOI: 10.1186/s12879-016-1687-8.
    [33] Nemeth J, Winkler HM, Zwick RH, et al. Peripheral T cell cytokine responses for diagnosis of active tuberculosis[J]. PLoS One, 2012, 7(4):e35290. DOI: 10.1371/journal.pone.0035290.
    [34] 张珍, 杨学刚, 孟娟, 等. Tspot.TB在艾滋病合并肺结核感染诊断中的应用[J].中国艾滋病性病, 2020, 26(4):432-433. DOI: 10.13419/j.cnki.aids.2020.04.24.

    Zhang Z, Yang XG, Meng J, et al. Application of Tspot.TB in the diagnosis of AIDS complicated with tuberculosis infection[J]. Chin J AIDS STD, 2020, 26(4), 432-433. DOI: 10.13419/j.cnki.aids.2020.04.24
    [35] 杨彤彤, 李弘, 王宗正, 等. T-SPOT.TB在HIV/AIDS合并结核病中的临床诊断价值[J].传染病信息, 2018, 31(6), 555-557. DOI: 10.3969/j.issn.1007-8134.2018.06.015.

    Yang TT, Li H, Wang ZZ, et al. Clinical diagnosis value of T-SPOT.TB in HIV/AIDS complicated tuberculosis[J]. Infect Dis Info, 2018, 31(6), 555-557. DOI: 10.3969/j.issn.1007-8134.2018.06.015.
    [36] 徐君君, 隆靖, 袁柳凤, 等.艾滋病合并结核病人的诊断与病人γ-干扰素释放试验检测结果差异的分析[J].中国艾滋病性病, 2016, 22(7):493-497. DOI: 10.13419/j.cnki.aids.2016.07.03.

    Xu JJ, Long J, Yuan LF, et al. Investigation of the difference between the clinical diagnosis of tuberculosis and the result of gam[J]. Chin J AIDS STD, 2016, 22(7):493-497. DOI: 10.13419/j.cnki.aids.2016.07.03.
    [37] 聂静敏, 钱娟, 何雪姣, 等.艾滋病合并结核病对CD4+/CD8+比值的影响[J].中华医院感染学杂志, 2020, 30(17):2615-2619. DOI: 10.11816/cn.ni.2020-192882.

    Nie JM, Qian J, He XJ, et al. Impact of AIDS combined with tuberculosis on CD4+/CD8+ ratio[J]. Chin J Nosocomiol, 2020, 30(17):2615-2619. DOI: 10.11816/cn.ni.2020-192882.
    [38] World Health Organization. Roadmap for rolling out Xpert MTB/RIF for rapid diagnosis of TB and MDR-TB[EB/OL]. (2010-12-08)[2020-10-24]. http://stoptb.org/wg/new_diagnostics/assets/documents/ROADMAP_FOR_ROLLING_OUT_XPERT_MTB-RIF-2010.pdf.
    [39] Mupfumi L, Mpande CAM, Reid T, et al. Immune phenotype and functionality of Mtb-specific T-cells in HIV/TB co-infected patients on antiretroviral treatment[J]. Pathogens, 2020, 9(3):180. DOI: 10.3390/pathogens9030180.
    [40] Mayito J, Meya DB, Rhein J, et al. Utility of the monocyte to lymphocyte ratio in diagnosing latent tuberculosis among HIVinfected individuals with a negative tuberculosis symptom screen[J]. PloS One, 2020, 15(11):e0241786. DOI: 10.1371/journal.pone.0241786.
    [41] Kisuya J, Chemtai A, Raballah E, et al. The diagnostic accuracy of Th1 (IFN-γ, TNF-α, and IL-2) and Th2 (IL-4, IL-6 and IL-10) cytokines response in AFB microscopy smear negative PTB- HIV co-infected patients[J]. Sci Rep, 2019, 9(1):2966. DOI: 10.1038/s41598-019-39048-x.
    [42] 韦湘, 顾武斌, 沙友马呷, 等.艾滋病合并肺结核与单纯性肺结核CT表现研究[J].现代医用影像学, 2019, 28(6):1297-1298. http://www.cnki.com.cn/Article/CJFDTotal-XDYY201906033.htm

    Wei X, Gu WB, Sha YMJ, et al. CT findings of AIDS combined with tuberculosis and simple tuberculosis[J]. Modern Med Imagel Bimonthly, 2019, 28(6):1297-1298. http://www.cnki.com.cn/Article/CJFDTotal-XDYY201906033.htm
    [43] 陈忠元龙, 李洋, 肖开提·米吉提.艾滋病合并肺结核与单纯性肺结核胸部CT特征及其对临床诊断价值分析[J].新疆医学, 2020, 50(5):429-432.

    Chen ZYL, Li Y, Xiao KT·MJT. Chest CT features of HIV/AIDS-complicated pulmonary tuberculosis and simple tuberculosis and its clinical diagnostic value[J]. Xinjiang Medical Journal. 2020, 50(5):429-432.
    [44] Boyles TH. Timing of antiretroviral therapy for HIV-1 infection and tuberculosis[J]. N Engl J Med, 2012, 366(5):474-475. DOI: 10.1056/NEJMc1113986.
    [45] Chelkeba L, Fekadu G, Tesfaye G, et al. Effects of time of initiation of antiretroviral therapy in the treatment of patients with HIV/TB co-infection: a systemic review and meta-analysis[J]. Ann Med Surg (Lond), 2020, 55:148-158. DOI: 10.1016/j.amsu.2020.05.004.
    [46] Djimeu EW, Heard AC. Treatment of HIV among tuberculosis patients: a replication study of timing of antiretroviral therapy for HIV-1-associated tuberculosis[J]. PLoS One, 2019, 14(2):e0210327. Doi: 10.1371/journal.pone.0210327.
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  • 收稿日期:  2020-10-30
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