• 中国精品科技期刊
  • 《中文核心期刊要目总览》收录期刊
  • RCCSE 中国核心期刊(5/114,A+)
  • Scopus收录期刊
  • 美国《化学文摘》(CA)收录期刊
  • WHO 西太平洋地区医学索引(WPRIM)收录期刊
  • 《中国科学引文数据库(CSCD)》核心库期刊 (C)
  • 中国科技核心期刊
  • 中国科技论文统计源期刊
  • 《日本科学技术振兴机构数据库(中国)》(JSTChina)收录期刊
  • 美国《乌利希期刊指南》(UIrichsweb)收录期刊
  • 中华预防医学会系列杂志优秀期刊(2019年)

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

艾滋病与结核病双重感染的研究进展

厉虹淼,  唐飞,  陈双双,  张根友,  吕莉萍,  史四九,  范引光

downloadPDF
文章导航 > 中华疾病控制杂志  > 2020 >  24(12): 1459-1464
厉虹淼, 唐飞, 陈双双, 张根友, 吕莉萍, 史四九, 范引光. 艾滋病与结核病双重感染的研究进展[J]. 中华疾病控制杂志, 2020, 24(12): 1459-1464. doi: 10.16462/j.cnki.zhjbkz.2020.12.018
引用本文: 厉虹淼, 唐飞, 陈双双, 张根友, 吕莉萍, 史四九, 范引光. 艾滋病与结核病双重感染的研究进展[J]. 中华疾病控制杂志, 2020, 24(12): 1459-1464. doi: 10.16462/j.cnki.zhjbkz.2020.12.018
shu
LI Hong-miao, TANG Fei, CHEN Shuang-shuang, ZHANG Gen-you, LYU Li-ping, SHI Si-jiu, FAN Yin-guang. Research progress of co-infection of acquired immune deficiency syndrome and tuberculosis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(12): 1459-1464. doi: 10.16462/j.cnki.zhjbkz.2020.12.018
Citation: LI Hong-miao, TANG Fei, CHEN Shuang-shuang, ZHANG Gen-you, LYU Li-ping, SHI Si-jiu, FAN Yin-guang. Research progress of co-infection of acquired immune deficiency syndrome and tuberculosis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(12): 1459-1464. doi: 10.16462/j.cnki.zhjbkz.2020.12.018
shu

艾滋病与结核病双重感染的研究进展

doi: 10.16462/j.cnki.zhjbkz.2020.12.018
  • 1.

    230022 合肥，安徽省结核病防治研究所卡介苗科

  • 2.

    230022 合肥，安徽省胸科医院内镜诊疗中心

  • 3.

    230022 合肥，安徽省结核病防治研究所科教科

  • 4.

    230032 合肥，安徽医科大学公共卫生学院流行病与卫生统计学系，炎症免疫性疾病安徽省实验室

厉虹淼和唐飞为共同第一作者.
基金项目: 

国家科技重大专项 2018ZX10302302-003-003

国家自然科学基金 82003515

安徽省自然科学基金 1908085QH368

中国疾病预防控制中心柳州市艾滋病技术支持项目 K2020043

详细信息
    通讯作者:

    史四九, E-mail:461912623@qq.com

    范引光, E-mail:fanyinguang@163.com

  • 中图分类号: R512.91;R521

Research progress of co-infection of acquired immune deficiency syndrome and tuberculosis

  • 1.

    BCG vaccine division, Anhui Institute of Tuberculosis Control, Hefei 230022, China

  • 2.

    Endoscopic Diagnosis and Treatment Center, Anhui Chest Hospital, Hefei 230022, China

  • 3.

    Science and Education Division, Anhui Institute of Tuberculosis Control, Hefei 230022, China

  • 4.

    Department of Epidemiology and Biostatiatics, School of Public Health, Anhui Medical University, Anhui Province Laboratory of Inflammation and Immune Mediated Diseases, Hefei 230032, China

LI Hong-miao and TANG Fei contribute equally to the article.
Funds: 

National Major Science and Technology Projects of China 2018ZX10302302-003-003

National Natural Science Foundation of China 82003515

Anhui Provincial Natural Science Foundation 1908085QH368

Program of technical support for Liuzhou City authorized by the Chinese National Center for AIDS/STD Control and Prevention K2020043

More Information

    摘要
  • 摘要: 艾滋病(acquired immune deficiency syndrome, AIDS)与结核病(tuberculosis, TB)双重感染可加快患者的病情进展，使患者各器官功能迅速衰竭，最终导致死亡。AIDS合并TB的防治不仅是临床面临的一大难题，也已成为全球范围内一个重大公共卫生问题。本文从AIDS/TB双重感染的流行现状、发病机制、临床特征、诊断方法、治疗方案及预防措施等角度出发，对这一重大公共卫生问题的研究现状进行综述，为制定降低AIDS与TB双重感染的措施提供科学依据。
    Abstract: The co-infection of acquired immune deficiency syndrome (AIDS) and tuberculosis (TB) can accelerate the disease progress, rapidly lead to the function failure of organs in patients, and finally lead to death. At present, the prevention and treatment of co-infection of AIDS and TB is not only a major clinical problem, but also has become a major public health problem in the world. In this paper, we reviewed the prevalence, pathogenesis, clinical features, diagnostic methods, treatment and preventive measures of HIV/TB double infection, in order to provide scientific basis for formulating measures to reduce the co-infection of AIDS and tuberculosis.
    • HTML全文
    • 参考文献(46)
  • [1] 联合国艾滋病规划署. 2020全球艾滋病防治进展报告[EB/OL]. (2020-07-20)[2020-10-30].http://www.unaids.org.cn/page122?article_id=1200.

    The Joint United Nations Programme on HIV/AIDS. Global AIDS progress report 2020[EB/OL]. (2020-07-20)[2020-10-30].http://www.unaids.org.cn/page122?article_id=1200.
    [2] 谢祎, 孙昕.结核病与艾滋病双重感染的流行现状与研究进展[J].中华医院感染学杂志, 2019, 29(19), 3036-3040. DOI: 10.11816/cn.ni.2019-182959.

    Xie Y, Sun X. Epidemiological status and research progress of co-infection of Mycobacterium tuberculosis and human[J]. Chin J Nosocomiol, 2019, 29(19):3036-3040. DOI: 10.11816/cn.ni.2019-182959.
    [3] 国家卫生健康委疾病预防控制局. 2019年全国法定传染病疫情概况[J].中国病毒病杂志, 2020, 10(4):245. http://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&filename=NKYT201901019

    Bureau of Disease Prevention and Control, National Health Commission. A brief overview of the notifiable infectious diseases in 2019[J]. Chin J Viral Dis, 2020, 10(4):245. http://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&filename=NKYT201901019
    [4] 李乐, 周子豪, 吴群红, 等. HIV感染者/AIDS患者中结核病检出率的meta分析[J].职业与健康, 2019, 35(24):3437-3441. DOI: 10.13329/j.cnki.zyyjk.2019.0918.

    Li L, Zhou ZH, Wu QH, et al. A meta-analysis of tuberculosis detection rate in HIV/AIDS patients[J]. Occup and Health, 2019, 35(24):3437-3441. DOI: 10.13329/j.cnki.zyyjk.2019.0918.
    [5] >World Health Organization. Global tuberculosis report 2019[EB/OL]. (2020-10-14)[2020-10-24].https://apps.who.int/iris/bitstream/handle/10665/336069/9789240013131-eng.pdf.
    [6] Getahun H, Gunneberg C, Granich R, et al. HIV infection-associated tuberculosis: the epidemiology and the response[J]. Clin Infect Dis, 2010, 50(suppl 3):S201-207.DOI: 10.1086/651492.
    [7] Sonnenberg P, Glynn JR, Fielding K, et al. How soon after infection with HIV does the risk of tuberculosis start to increase? A etrospective cohort study in South African gold miners[J]. J Infect Dis, 2005, 191(2):150-158. DOI: 10.1086/426827.
    [8] Wolf AJ, Linas B, Trevejo-Nunez GJ, et al. Mycobacterium tuberculosis infects dendritic cells with high frequency and impairs their function in vivo[J]. J Immunol, 2007, 179(4):2509-2519. DOI: 10.4049/jimmunol.179.4.2509.
    [9] Egen JG, Rothfuchs AG, Feng CG, et al. Intravital imaging reveals limited antigen presentation and T cell effector function in mycobacterial granulomas[J]. Immunity, 2011, 34(5):807-19. DOI: 10.1016/j.immuni.2011.03.022.
    [10] Reece ST, Kaufmann SH. Floating between the poles of pathology and protection: can we pin down the granuloma in tuberculosis?[J]. Curr Opin Microbiol, 2012, 15(1):63-70. DOI: 10.1016/j.mib.2011.10.006.
    [11] Christof G, Alimuddin Z, Michael H. Interaction between HIV and Mycobacterium tuberculosis: HIV-1-induced CD4 T-cell depletion and the development of active tuberculosis[J]. Curr Opin HIV AIDS, 2012, 7(3):268-275. DOI: 10.1097/COH.0b013e3283524e32.
    [12] Björn C, Allison NB, Maud D, et al. HIV-1 and SIV infection are associated with early loss of lung interstitial CD4+ T cells and dissemination of pulmonary tuberculosis[J]. Cell Reports, 2019, 26(6):1409-1418. DOI: 10.1016/j.celrep.2019.01.021.
    [13] Nada P, Panadda D, Shinsaku S, et al. Coordinated in vitro release of granulysin, perforin and IFN- in TB and HIV/TB co-infection associated with clinical outcomes before and after anti-TB treatment[J]. Pathogens, 2020, 14, 9(8):655. DOI: 10.3390/pathogens9080655.
    [14] Nada P, Shinsaku S, Takahiro T, et al. Potential function of granulysin, other related effector molecules and lymphocyte subsets in patients with TB and HIV/TB coinfection[J]. Int J Med Sci, 2013, 10(8):1003-1014. DOI: 10.7150/ijms.6437.
    [15] Marcela MT, Jôsimar DM, Fernanda FCN, et al. Evaluation of profile and functionality of memory T cells in pulmonary tuberculosis[J]. Immunol Lett, 2017, 192:52-60. DOI: 10.1016/j.imlet.2017.10.014.
    [16] Ramana Rao PV, Rajasekaran S, Raja A. Natural killer cell-mediated cytokine response among HIV-positive south Indians with pulmonary tuberculosis[J]. J Interferon Cytokine Res, 2010, 30(1):33-42. DOI: 10.1089/jir.2009.0018.
    [17] Raghavan S, Alagarasu K, Selvaraj P. Immunogenetics of HIV and HIV associated tuberculosis[J]. Tuberculosis (Edinb), 2012, 92(1):18-30. DOI: 10.1016/j.tube.2011.08.004.
    [18] Esther van W, Edward BI, Leela D, et al. HIV is associated with modified humoral immune responses in the setting of HIV/TB coinfection[J]. mSphere, 2020, 5(3):e00104-20. DOI: 10.1128/mSphere.00104-20.
    [19] 阮军, 尹恒, 寇国先, 等.艾滋病合并肺结核259例临床分析[J].中国艾滋病性病, 2020, 26(5):490-492. DOI: 10.13419/j.cnki.aids.2020.05.09.

    Ruan J, Yin H, Kou GX, et al. Clinical analysis of 259 cases of AIDS complicated with pulmonary tuberculosis[J]. Chin J AIDS STD, 2020, 26(5):490-492. DOI: 10.13419/j.cnki.aids.2020.05.09.
    [20] Fausto C, Francesca L, Roberto L, et al. Hematologic alterations and early mortality in a cohort of HIV positive African patients[J]. PloS One, 2020, 15(11): e0242068. DOI: 10.1371/journal.pone.0242068.
    [21] 葛晓飞, 任彦微, 陈宇飞, 等.艾滋病合并肺结核临床特点分析[J].中国现代药物应用, 2020, 14(1):41-42. DOI: 10.14164/j.cnki.cn11-5581/r.2020.01.019.

    Ge XF, Ren YW, Chen YF, et al. Analysis of clinical characteristics of AIDS complicated with tuberculosis[J]. Chin J Mod Drug, 2020, 14(1):41-42. DOI: 10.14164/j.cnki.cn11-5581/r.2020.01.019.
    [22] 曹世敏, 胡丽华.艾滋病合并肺结核临床特点及其治疗[J].中外医疗, 2018, 37(12):31-33. DOI: 10.16662/j.cnki.1674-0742.2018.12.031.

    Cao SM, Hu LH. Clinical characteristics and treatment of AIDS combined with pulmonary tuberculosis[J]. China & Foreign Medical Treatment, 2018, 37(12):31-33. DOI: 10.16662/j.cnki.1674-0742.2018.12.031.
    [23] 敬苑霖.艾滋病合并肺结核的临床诊断相关研究[J].世界最新医学信息文摘, 2018, 18(2):63-64. DOI: 10.19613/j.cnki.1671-3141.2018.02.044.

    Jing YL. Study on the clinical diagnosis of AIDS complicated with tuberculosis[J]. World Latest Medicne Information, 2018, 18(2):63-64. DOI: 10.19613/j.cnki.1671-3141.2018.02.044
    [24] 张林, 王永素, 苗瑞红, 等.艾滋病合并肺结核病患者综合特征分析[J].临床肺科杂志, 2019, 24(12):2227-2230. DOI: 10.3969/j.issn.1009-6663.2019.12.021.

    Zhang L, Wang YS, Miao RH, et al. Comprehensive characteristics analysis of HIV/TB patients[J]. Journal of Clinical Pulmonary Medicine, 2019, 24(12):2227-2230. DOI: 10.3969/j.issn.1009-6663.2019.12.021.
    [25] 张彦, 胡国启, 司丽, 等.艾滋病合并肺结核与单纯肺结核患者的临床特点对比分析研究[J].传染病信息, 2018, 31(6):552-554. DOI: 10.3969/j.issn.1007-8134.2018.06.014

    Zhang Y, Hu GQ, Si L, et al. A comparative study on clinical characteristics of AIDS patients with pulmonary tuberculosis and sim[J]. Infect Dis Info, 2018, 31(6):552-554. DOI: 10.3969/j.issn.1007-8134.2018.06.014.
    [26] 李春华, 刘雪艳, 吕圣秀, 等.艾滋病并发血行播散性肺结核的临床及CT表现分析[J].中国艾滋病性病, 2019, 25(11):1101-1104. DOI: 10.13419/j.cnki.aids.2019.11.02

    Li CH, Liu XY, Lv SX, et al. Analysis of clinical and CT manifestations of AIDS with concurrent hematogenous disseminated pulmona[J] Chin J AIDS STD, 2019, 25(11):1101-1104. DOI: 10.13419/j.cnki.aids.2019.11.02
    [27] 许禹. 80例艾滋病合并肺结核患者胸部CT影像学特征研究[J].皮肤病与性病, 2019, 41(2):198-200. DOI: 10.3969/j.issn.1002-1310.2019.02.017.

    Xun Y. Chest CT imaging characteristics of 80 AIDS patients with pulmonary tuberculosis[J]. J Dermatology and Venereology, 2019, 41(2):198-200. DOI: 10.3969/j.issn.1002-1310.2019.02.017.
    [28] 孔令周, 王京华.艾滋病合并肺结核的CT影像学诊断[J].现代医用影像学, 2020, 29(3):507-508. http://med.wanfangdata.com.cn/Paper/Detail?id=PeriodicalPaper_xdyyyxx202003037

    Sun LZ, Wang JH. CT imaging diagnosis of AIDS complicated with pulmonary tuberculosis[J]. Modern Med Imagel Bimonthly, 2020, 29(3):507-508. http://med.wanfangdata.com.cn/Paper/Detail?id=PeriodicalPaper_xdyyyxx202003037
    [29] 中华医学会感染病学分会艾滋病丙型肝炎学组, 中国疾病预防控制中心.中国艾滋病诊疗指南(2018版)[J].新发传染病电子杂志, 2019, 4(2):65-84. http://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&filename=CRBX201901004

    AIDS and Hepatitis C Professional Group, Society of Infectious Diseases, Chinese Medical Association, Chinese Center for Disease Control and Prevention. Chinese guidelines for diagnosis and treatment of HIV/AIDS (2018 edition)[J]. Electronic Journal of Emerging Infectious Diseases, 2019, 4(2):65-84. http://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&filename=CRBX201901004
    [30] 边泽源, 杨云红, 吴芝炜, 等. γ干扰素释放试验在HIV合并TB感染中的应用价值[J].实验与检验医学, 2019, 37(6):1012-1014. DOI: 10.3969/j.issn.1674-1129.2019.06.008.

    Bian ZY, Yang YB, Wu ZW, et al. The application value of γ-interferon release test in HIV combined with tuberculosis infection[J]. Experimental and Laboratory Medicine, 2019, 37(6):1012-1014. DOI: 10.3969/j.issn.1674-1129.2019.06.008.
    [31] Liang Y, Wang Y, Li H, et al. Evalution of a wholeblood chemi-luminescent immunoassay of IFN-γ, IP-10, and MCP-1 fordiagno-sis of active pulmonary tuberculosis and tuberculous pleurisy pa-tients[J]. APMIS, 2016, 124(10):856-864. DOI: 10.1111/apm.12583.
    [32] Huo ZY, Peng L. Accuracy of the interferon-gamma release assay for the diagnosis of active tuberculosis among HIVseropositive individuals: a systematic review and meta-analysis[J]. BMC Infect Dis, 2016, 16:350. DOI: 10.1186/s12879-016-1687-8.
    [33] Nemeth J, Winkler HM, Zwick RH, et al. Peripheral T cell cytokine responses for diagnosis of active tuberculosis[J]. PLoS One, 2012, 7(4):e35290. DOI: 10.1371/journal.pone.0035290.
    [34] 张珍, 杨学刚, 孟娟, 等. Tspot.TB在艾滋病合并肺结核感染诊断中的应用[J].中国艾滋病性病, 2020, 26(4):432-433. DOI: 10.13419/j.cnki.aids.2020.04.24.

    Zhang Z, Yang XG, Meng J, et al. Application of Tspot.TB in the diagnosis of AIDS complicated with tuberculosis infection[J]. Chin J AIDS STD, 2020, 26(4), 432-433. DOI: 10.13419/j.cnki.aids.2020.04.24
    [35] 杨彤彤, 李弘, 王宗正, 等. T-SPOT.TB在HIV/AIDS合并结核病中的临床诊断价值[J].传染病信息, 2018, 31(6), 555-557. DOI: 10.3969/j.issn.1007-8134.2018.06.015.

    Yang TT, Li H, Wang ZZ, et al. Clinical diagnosis value of T-SPOT.TB in HIV/AIDS complicated tuberculosis[J]. Infect Dis Info, 2018, 31(6), 555-557. DOI: 10.3969/j.issn.1007-8134.2018.06.015.
    [36] 徐君君, 隆靖, 袁柳凤, 等.艾滋病合并结核病人的诊断与病人γ－干扰素释放试验检测结果差异的分析[J].中国艾滋病性病, 2016, 22(7):493-497. DOI: 10.13419/j.cnki.aids.2016.07.03.

    Xu JJ, Long J, Yuan LF, et al. Investigation of the difference between the clinical diagnosis of tuberculosis and the result of gam[J]. Chin J AIDS STD, 2016, 22(7):493-497. DOI: 10.13419/j.cnki.aids.2016.07.03.
    [37] 聂静敏, 钱娟, 何雪姣, 等.艾滋病合并结核病对CD4+/CD8+比值的影响[J].中华医院感染学杂志, 2020, 30(17):2615-2619. DOI: 10.11816/cn.ni.2020-192882.

    Nie JM, Qian J, He XJ, et al. Impact of AIDS combined with tuberculosis on CD4+/CD8+ ratio[J]. Chin J Nosocomiol, 2020, 30(17):2615-2619. DOI: 10.11816/cn.ni.2020-192882.
    [38] World Health Organization. Roadmap for rolling out Xpert MTB/RIF for rapid diagnosis of TB and MDR-TB[EB/OL]. (2010-12-08)[2020-10-24]. http://stoptb.org/wg/new_diagnostics/assets/documents/ROADMAP_FOR_ROLLING_OUT_XPERT_MTB-RIF-2010.pdf.
    [39] Mupfumi L, Mpande CAM, Reid T, et al. Immune phenotype and functionality of Mtb-specific T-cells in HIV/TB co-infected patients on antiretroviral treatment[J]. Pathogens, 2020, 9(3):180. DOI: 10.3390/pathogens9030180.
    [40] Mayito J, Meya DB, Rhein J, et al. Utility of the monocyte to lymphocyte ratio in diagnosing latent tuberculosis among HIVinfected individuals with a negative tuberculosis symptom screen[J]. PloS One, 2020, 15(11):e0241786. DOI: 10.1371/journal.pone.0241786.
    [41] Kisuya J, Chemtai A, Raballah E, et al. The diagnostic accuracy of Th1 (IFN-γ, TNF-α, and IL-2) and Th2 (IL-4, IL-6 and IL-10) cytokines response in AFB microscopy smear negative PTB- HIV co-infected patients[J]. Sci Rep, 2019, 9(1):2966. DOI: 10.1038/s41598-019-39048-x.
    [42] 韦湘, 顾武斌, 沙友马呷, 等.艾滋病合并肺结核与单纯性肺结核CT表现研究[J].现代医用影像学, 2019, 28(6):1297-1298. http://www.cnki.com.cn/Article/CJFDTotal-XDYY201906033.htm

    Wei X, Gu WB, Sha YMJ, et al. CT findings of AIDS combined with tuberculosis and simple tuberculosis[J]. Modern Med Imagel Bimonthly, 2019, 28(6):1297-1298. http://www.cnki.com.cn/Article/CJFDTotal-XDYY201906033.htm
    [43] 陈忠元龙, 李洋, 肖开提·米吉提.艾滋病合并肺结核与单纯性肺结核胸部CT特征及其对临床诊断价值分析[J].新疆医学, 2020, 50(5):429-432.

    Chen ZYL, Li Y, Xiao KT·MJT. Chest CT features of HIV/AIDS-complicated pulmonary tuberculosis and simple tuberculosis and its clinical diagnostic value[J]. Xinjiang Medical Journal. 2020, 50(5):429-432.
    [44] Boyles TH. Timing of antiretroviral therapy for HIV-1 infection and tuberculosis[J]. N Engl J Med, 2012, 366(5):474-475. DOI: 10.1056/NEJMc1113986.
    [45] Chelkeba L, Fekadu G, Tesfaye G, et al. Effects of time of initiation of antiretroviral therapy in the treatment of patients with HIV/TB co-infection: a systemic review and meta-analysis[J]. Ann Med Surg (Lond), 2020, 55:148-158. DOI: 10.1016/j.amsu.2020.05.004.
    [46] Djimeu EW, Heard AC. Treatment of HIV among tuberculosis patients: a replication study of timing of antiretroviral therapy for HIV-1-associated tuberculosis[J]. PLoS One, 2019, 14(2):e0210327. Doi: 10.1371/journal.pone.0210327.
    • 相关文章
    • 施引文献
  • 资源附件(0)
  • 加载中
WeChat 点击查看大图
计量
  • 文章访问数:  610
  • HTML全文浏览量:  770
  • PDF下载量:  173
  • 被引次数: 0
出版历程
  • 收稿日期:  2020-10-30
  • 修回日期:  2020-11-25
  • 刊出日期:  2020-12-10

目录

    /

    返回文章
    返回

    版权所有 © 《中华疾病控制杂志》编辑部 皖ICP备05003562号

    本系统由 北京仁和汇智信息技术有限公司 开发