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2016-2018年德宏傣族景颇族自治州婚检人群HBV感染率及影响因素

龚渝蓉,  张晗希,  唐树萍,  杨世江,  尹寿欢,  杨跃诚,  叶润华,  王璐,  丁盈盈,  何纳,  段松

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文章导航 > 中华疾病控制杂志  > 2021 >  25(1): 48-53
龚渝蓉, 张晗希, 唐树萍, 杨世江, 尹寿欢, 杨跃诚, 叶润华, 王璐, 丁盈盈, 何纳, 段松. 2016-2018年德宏傣族景颇族自治州婚检人群HBV感染率及影响因素[J]. 中华疾病控制杂志, 2021, 25(1): 48-53. doi: 10.16462/j.cnki.zhjbkz.2021.01.010
引用本文: 龚渝蓉, 张晗希, 唐树萍, 杨世江, 尹寿欢, 杨跃诚, 叶润华, 王璐, 丁盈盈, 何纳, 段松. 2016-2018年德宏傣族景颇族自治州婚检人群HBV感染率及影响因素[J]. 中华疾病控制杂志, 2021, 25(1): 48-53. doi: 10.16462/j.cnki.zhjbkz.2021.01.010
shu
GONG Yu-rong, ZHANG Han-xi, TANG Shu-ping, YANG Shi-jiang, YIN Shou-huan, YANG Yue-cheng, YE Run-hua, WANG Lu, DING Ying-ying, HE Na, DUAN Song. HBV prevalence and associated factors among persons receiving premarital medical examination in Dehong Dai and Jingpo Autonomous Prefecture during 2016-2018[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(1): 48-53. doi: 10.16462/j.cnki.zhjbkz.2021.01.010
Citation: GONG Yu-rong, ZHANG Han-xi, TANG Shu-ping, YANG Shi-jiang, YIN Shou-huan, YANG Yue-cheng, YE Run-hua, WANG Lu, DING Ying-ying, HE Na, DUAN Song. HBV prevalence and associated factors among persons receiving premarital medical examination in Dehong Dai and Jingpo Autonomous Prefecture during 2016-2018[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(1): 48-53. doi: 10.16462/j.cnki.zhjbkz.2021.01.010
shu

2016-2018年德宏傣族景颇族自治州婚检人群HBV感染率及影响因素

doi: 10.16462/j.cnki.zhjbkz.2021.01.010
  • 1.

    678400 芒市，云南德宏傣族景颇族自治州疾病预防控制中心性病艾滋病防制科

  • 2.

    102206 北京，中国疾病预防控制中心性病艾滋病预防控制中心党群人事办公室

  • 3.

    678400 芒市，云南德宏州妇幼保健院公共卫生管理科

  • 4.

    200032 上海，复旦大学公共卫生学院流行病学教研室，公共卫生安全教育部重点实验室

龚渝蓉和张晗希为共同第一作者
基金项目: 

国家科技重大专项 2018ZX10715006-001

国家科技重大专项 2018ZX10721102-004

国家重点地区艾滋病防治项目 WeiBanJiKongfa〔2004〕49

详细信息
    通讯作者:

    段松，E-mail：dhduansong@sina.com.cn

    何纳，E-mail：nhe@shmu.edu.cn

  • 中图分类号: R512.6+2

HBV prevalence and associated factors among persons receiving premarital medical examination in Dehong Dai and Jingpo Autonomous Prefecture during 2016-2018

  • 1.

    Department of Sexual and AIDS Prevention Dehong Prefecture Center for Disease Control and Prevention, Mangshi 678400, China

  • 2.

    Department of the Party and the Masses Affairs, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China

  • 3.

    Department of Public Health Management Dehong Prefecture Center for Maternal and Child Care Service, Mangshi 678400, China

  • 4.

    Department of Epidemiology, School of Public Health, Fudan University; Key Laboratory of Health Technology Assessment of Ministry of Health, Fudan University, Shanghai 200032, China

GONG Yu-rong and ZHANG Han-xi contributed equally to this article
Funds: 

Chinese Major National Science and Technology Projects 2018ZX10715006-001

Chinese Major National Science and Technology Projects 2018ZX10721102-004

HIV/AIDS Control and Prevention Projects in Key Areas of the Country WeiBanJiKongfa〔2004〕49

More Information
    Corresponding author: HE Na, E-mail: nhe@shmu.edu.cn; DUAN Song, E-mail: dhduansong@sina.com.cn

    摘要
  • 摘要:   目的  了解云南德宏傣族景颇族自治州2016-2018年婚检人群HBV感染情况，探讨HBV感染的主要影响因素，为推动德宏州乙型肝炎(简称乙肝)防治工作的开展提供科学依据。  方法  对2016-2018年婚检对象的血清标本进行HBsAg检测，按照检测血清号进行配对，进行多因素Logistic线性回归分析模型分析。  结果  在65 639例婚检对象中，HBV感染率为3.05%(1 874/61 352)；按照婚检双方是否感染HBV分为：双阴性、男阳性女阴性、男阴性女阳性和双阳性四类；结果显示，婚检双方至少一方为阳性者1 773对，占5.90%(1 773/30 068)，且以男阳性女阴性为主，占3.59%(1 079/30 068)。分析四类人群构成趋势变化发现，男女均阳性者和男阴性女阳性者有所减少，男女均阴性者有所增加(均有P＜0.05)。多因素分析结果显示，男阴性女阳性与双阴性对比，女性年龄≥30岁以及男性为中国籍、女性为外籍和双方均为外籍相对于均为中国籍是HBV感染的危险因素(均有P＜0.05)。  结论  云南德宏傣族景颇族自治州婚检人群中HBV感染率有所下降，女性HBV感染可能在当地HBV传播中起到重要作用。依据所发现的HBV感染的影响因素进行科学防治，可减少HBV在婚检人群中的传播。
    Abstract:   Objective  To investigate the hepatitis B virus (HBV) prevalence among the pre-marital medical examination population in Dehong Dai and Jingpo Autonomous Prefecture from 2016 to 2018, and to explore the main factors of HBV infection.  Methods  Hepatitis B surface antigen was detected in serum samples of premarital medical examination subjects from 2016 to 2018. And, the main influencing factors of HBV infection were explored by multivariable Logistic liner regression model based on paired premarital subjects which were according to the serum test number.  Results  A total of 65 639 premarital subjects were tested, and HBV infection rate was 3.05%(1 874/61 352). Based on the HBV infection results, we divided the participants into four categories: both negative, male positive but female negative, male negative but female positive and both positive. The results showed that there were 1 773 pairs in which more than one person was positive accounted for 5.90% (1 773/30 068), and most of that was male positive but female negative, which accounted for 3.59% (1 079/30 068). According to the analysis of the composition of the four groups of people in each year, it was found the decrease in the category of both negative and in the category of male negative but female positive, and the increase in the category of both negative (P < 0.05). The results of multivariate analysis showed that the risk factors were female age ≥ 30 years old, Chinese nationality of male, foreign nationality of female and foreign nationality of both sides (all P < 0.05) in the male negative but female positive compared with both negative.  Conclusions  Detection of HBV infection in the premarital medical examination population in Dehong Dai and Jingpo Autonomous Prefecture was decreased, and HBV-positive female may play an important role in local HBV transmission. The finding of risk factors of HBV infection might be useful for reducing the spread of HBV.
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  • 表  1  德宏傣族景颇族自治州2016-2018年婚检人群社会人口学特征[n(%)]

    Table  1.   Social-demographic characteristics of pre-marital medical examination population in Dehong Dai and Jingpo Autonomous Prefecture from 2016 to 2018 [n(%)]

    变量 乙肝表面抗原检测情况 合计
    男女(-) 男(+)女(-) 男(-)女(+) 男女(+)
    是否 < 30岁
      男女均是 20 842(95.31) 626(2.86) 364(1.64) 34(0.15) 21 866(36.36)
      男是女否 2 786(93.43) 116(3.89) 76(2.55) 4(0.13) 2 982(4.95)
      女是男否 10 352(94.26) 404(3.68) 200(1.82) 26(0.24) 10 982(18.26)
      男女均否 22 610(93.02) 1 012(4.16) 624(4.16) 60(0.25) 24 306(40.42)
    是否为汉族
      男女均是 20 062(94.36) 760(3.57) 408(1.92) 32(0.15) 21 262(35.36)
      男是女否 9 588(93.29) 428(4.16) 244(2.37) 18(0.18) 10 278(17.09)
      女是男否 4 150(95.62) 118(2.72) 64(1.47) 8(0.18) 4 340(7.20)
      男女均否 22 790(93.96) 852(3.51) 548(2.26) 66(0.27) 24 256(40.34)
    是否初中及以下学历
      男女均是 38 424(93.78) 1 516(3.70) 934(2.28) 98(0.24) 40 972(68.13)
      男是女否 4 104(93.78) 194(4.43) 72(1.65) 6(0.14) 4 376(7.28)
      女是男否 3 470(93.58) 150(4.05) 84(2.27) 4(0.11) 3 708(6.17)
      男女均否 10 592(95.60) 298(2.69) 174(1.57) 16(0.14) 11 080(18.42)
    是否为农民a
      男女均是 40 542(94.00) 1 542(3.58) 960(2.23) 88(0.20) 43 132(71.73)
      男是女否 1 298(96.29) 32(2.37) 18(1.34) 0(0.00) 1 348(2.24)
      女是男否 1 832(95.32) 56(2.91) 34(1.77) 0(0.00) 1 922(3.19)
      男女均否 12 918(94.07) 528(3.85) 250(1.82) 36(0.26) 13 732(22.83)
    是否中国籍
      男女均是 51 448(94.23) 1 954(3.58) 1 092(2.00) 104(0.19) 54 598(90.79)
      男是女否 4 838(93.04) 190(3.65) 158(3.04) 14(0.27) 5 200(8.65)
      女是男否 296(90.24) 14(4.27) 12(3.66) 6(1.83) 328(0.55)
      男女均否 8(80.00) 0(0.00) 2(20.00) 0(0.00) 10(0.02)
    是否有婚前性行为a
      男女均是 50 586(94.07) 1 948(3.62) 1 138(2.12) 102(0.19) 53 774(89.47)
      男是女否 146(94.81) 2(1.30) 6(3.90) 0(0.00) 154(0.26)
      女是男否 126(90.00) 12(8.57) 0(0.00) 2(1.43) 140(0.23)
      男女均否 5 700(94.43) 196(3.25) 120(1.99) 20(0.33) 6 036(10.04)
    注：a数据有少量缺失。
    下载: 导出CSV

    表  2  德宏傣族景颇族自治州2016-2018年婚检双方HBV感染率[n(%)]

    Table  2.   HBV infection rate among pre-marital medical examination population in Dehong Dai and Jingpo Autonomous Prefecture from 2016 to 2018 [n(%)]

    类别 2016年 2017年 2018年 合计 χ2趋势值 P值
    HBV 8.125 0.004
    阳 793(3.37) 577(2.81) 504(2.91) 1 874(3.05)
    阴 22 741(96.63) 19 949(97.19) 16 788(97.09) 59 478(96.95)
    下载: 导出CSV

    表  3  德宏傣族景颇族自治州2016-2018年婚检双方HBV感染率分布[n(%)]

    Table  3.   Categories of HBV infection rate among paired pre-marital medical examination population in Dehong Dai and Jingpo Autonomous Prefecture from 2016 to 2018[n(%)]

    类别 合计 2016年 2017年 2018年 χ2趋势值 P值
    男女均阴性 28 295(94.10) 10 764(93.52) 9 582(94.55) 7 949(94.35) 6.977 0.008
    男阳性女阴性 1 079(3.59) 436(3.79) 3342(3.37) 301(3.57) 0.872 0.350
    男阴性女阳性 632(2.10) 275(2.39) 3192(1.90) 165(1.96) 5.056 0.024
    男女均阳性 62(0.21) 34(0.30) 18(0.18) 10(0.12) 7.709 0.005
    合计 30 068(100.00) 311 509(100.00) 10 134(100.00) 8 425(100.00)
    下载: 导出CSV

    表  4  德宏傣族景颇族自治州婚检双方HBV感染的影响因素分析

    Table  4.   Risk factors of HBV infection among pre-marital medical examination population in Dehong Dai and Jingpo Autonomous Prefecture from 2016 to 2018

    变量 男阳性女阴性与男女均阴性比 男阴性女阳性与男女均阴性比 男女均阳性与男女均阴性比
    OR(95% CI)值 P值 OR(95% CI)值 P值 OR(95% CI)值 P值
    是否 < 30岁
      男女均是 1.000 1.000 1.000
      男是女否 1.360(1.111~1.666) 0.003 1.528(1.189~1.964) 0.001 0.812(0.287~2.296) 0.706
      女是男否 1.307(1.150~1.486) < 0.001 1.073(0.901~1.278) 0.436 1.504(0.899~2.517) 0.119
      男女均否 1.481(1.335~1.642) < 0.001 1.512(1.324~1.727) < 0.001 1.506(0.983~2.308) 0.059
    是否为汉族
      男女均是 1.000 1.000 1.000
      男是女否 1.161(1.028~1.311) 0.017 1.250(1.063~1.469) 0.007 1.190(0.673~2.141) 0.541
      女是男否 0.778(0.638~0.948) 0.013 0.810(0.620~1.058) 0.119 1.263(0.579~2.746) 0.569
      男女均否 0.990(0.893~1.098) 0.865 1.108(0.970~1.267) 0.135 1.762(1.143~2.736) 0.012
    是否初中及以下学历
      男女均是 1.000 1.000 1.000
      男是女否 1.214(1.029~1.432) 0.020 0.852(0.660~1.099) 0.221 0.607(0.256~1.436) 0.266
      女是男否 1.037(0.866~1.242) 0.698 1.086(0.857~1.377) 0.494 0.445(0.159~1.242) 0.121
      男女均否 0.586(0.497~0.590) < 0.001 0.781(0.629~0.972) 0.028 0.410(0.205~0.787) 0.008
    是否为农民
      男女均是 1.000 1.000 1.000
      男是女否 0.710(0.494~1.022) 0.066 0.807(0.510~1.277) 0.352 -a -a
      女是男否 0.843(0.639~1.113) 0.227 0.836(0.587~1.192) 0.319 -a -a
      男女均否 1.431(1.254~1.634) < 0.001 1.024(0.849~1.234) 0.813 2.554(1.547~4.195) < 0.001
    是否中国籍
      男女均是 1.000 1.000 1.000
      男是女否 0.962(0.824~1.123) 0.637 1.401(1.177~1.667) < 0.001 1.184(0.668~2.091) 0.578
      女是男否 1.146(0.667~1.967) 0.616 1.790(0.999~3.206) 0.051 6.980(2.950~16.502) < 0.001
      男女均否 -a -a 11.108(2.344~52.636) 0.002 -a -a
    是否有婚前性行为
      男女均是 1.000 1.000 1.000
      男是女否 0.340(0.086~1.413) 0.147 1.773(0.781~4.029) 0.173 -a -a
      女是男否 2.492(1.372~4.523) 0.003 -a -a 8.012(1.956~32.973) 0.004
      男女均否 0.859(0.739~0.998) 0.047 0.915(0.756~1.107) 0.351 1.644(1.012~2.654) 0.046
    注：a该类别中数据为0，不进行统计分析。
    下载: 导出CSV
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  • 收稿日期:  2020-05-19
  • 修回日期:  2020-08-10
  • 刊出日期:  2021-01-10

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