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胎儿脐带缠绕与环境暴露因素的关联

岳和欣,  黎小秀,  湛永乐,  陈云利,  石英杰,  刘璇,  景傲,  孟耀涵,  吕天琛,  曲翌敏,  马良坤,  满冬梅,  江宇

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文章导航 > 中华疾病控制杂志  > 2021 >  25(2): 133-137
岳和欣, 黎小秀, 湛永乐, 陈云利, 石英杰, 刘璇, 景傲, 孟耀涵, 吕天琛, 曲翌敏, 马良坤, 满冬梅, 江宇. 胎儿脐带缠绕与环境暴露因素的关联[J]. 中华疾病控制杂志, 2021, 25(2): 133-137. doi: 10.16462/j.cnki.zhjbkz.2021.02.003
引用本文: 岳和欣, 黎小秀, 湛永乐, 陈云利, 石英杰, 刘璇, 景傲, 孟耀涵, 吕天琛, 曲翌敏, 马良坤, 满冬梅, 江宇. 胎儿脐带缠绕与环境暴露因素的关联[J]. 中华疾病控制杂志, 2021, 25(2): 133-137. doi: 10.16462/j.cnki.zhjbkz.2021.02.003
shu
YUE He-xin, LI Xiao-xiu, ZHAN Yong-le, CHEN Yun-li, SHI Ying-jie, LIU Xuan, JING Ao, MENG Yao-han, LYU Tian-chen, QU Yi-min, MA Liang-kun, MAN Dong-mei, JIANG Yu. The relationship between fetal umbilical cord entanglement and environmental exposure factors[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(2): 133-137. doi: 10.16462/j.cnki.zhjbkz.2021.02.003
Citation: YUE He-xin, LI Xiao-xiu, ZHAN Yong-le, CHEN Yun-li, SHI Ying-jie, LIU Xuan, JING Ao, MENG Yao-han, LYU Tian-chen, QU Yi-min, MA Liang-kun, MAN Dong-mei, JIANG Yu. The relationship between fetal umbilical cord entanglement and environmental exposure factors[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(2): 133-137. doi: 10.16462/j.cnki.zhjbkz.2021.02.003
shu

胎儿脐带缠绕与环境暴露因素的关联

doi: 10.16462/j.cnki.zhjbkz.2021.02.003
  • 1.

    100730 北京，中国医学科学院/北京协和医学院群医学及公共卫生学院流行病与生物统计学系

  • 2.

    523000 东莞，东莞市妇幼保健院儿科

  • 3.

    100005 北京，中国医学科学院/北京协和医学院北京协和医院妇产科

  • 4.

    272000 济宁，济宁医学院附属医院产科

岳和欣和黎小秀为共同第一作者
基金项目: 

中国医学科学院医学与健康科技创新工程 2019-I2M-2-007

详细信息
    通讯作者:

    满冬梅，E-mail: mandongmei@163.com

    江宇，E-mail：jiangyu@pumc.edu.cn

  • 中图分类号: R714.5

The relationship between fetal umbilical cord entanglement and environmental exposure factors

  • 1.

    Department of Epidemiology and Biostatistics, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China

  • 2.

    Department of Pediatrics, Dongguan Maternal and Child Health Care Hospital, Dongguan 523000, China

  • 3.

    Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China

  • 4.

    Department of Obstetrics, Affiliated Hospital of Jining Medical University, Jining 272000, China

YUE He-xin and LI Xiao-xiu contributed equally to this article
Funds: 

CAMS Innovation Fund for Medical Sciences (CIFMS) 2019-I2M-2-007

More Information

    摘要
  • 摘要:   目的  了解中国胎儿脐带缠绕现状及其与环境暴露因素的相关性，为预防和干预脐带缠绕提供科学的指导。  方法  以中国孕产妇队列研究·协和项目的孕妇为研究对象，在孕早期收集孕妇的一般人口学信息和环境暴露信息，随访获取脐带缠绕相关结局，应用多因素非条件Logistic回归分析模型分析胎儿脐带缠绕的影响因素。  结果  胎儿脐带缠绕的发生率为9.00%。Logistic回归分析模型分析结果显示：调整混杂因素后，与孕期没有暴露于被动吸烟或噪声的孕妇相比，暴露于被动吸烟(OR=1.199, 95% CI: 1.010~1.423, P=0.038)或噪声(OR=1.242, 95% CI: 1.002~1.541, P=0.048)的孕妇发生脐带缠绕的风险较高。  结论  孕妇孕期被动吸烟和接触噪声对胎儿脐带缠绕有影响，应加强孕期教育，减少孕妇孕期被动吸烟和噪声环境暴露。
    Abstract:   Objective  To understand the incidence of fetal umbilical cord entanglement in China and its correlation with environmental exposure factors, so as to provide scientific guidance for prevention and intervention of umbilical cord entanglement.  Methods  The pregnant women of the Chinese Pregnant Women Cohort Study were selected as the research subjects. The general demographic information and environmental exposure information of pregnant women were collected in the early pregnancy, and the related outcomes of umbilical cord entanglement were obtained by follow-up. Multivariate unconditional Logistic regression analysis model was used to analyze the influencing factors of fetal umbilical cord entanglement.  Results  The incidence of fetal umbilical cord entanglement was 9.00%. The results of Logistic regression analysis showed that after adjusting for confounding factors, pregnant women exposed to passive smoking (OR=1.199, 95% CI: 1.010-1.423, P=0.038) or noise (OR=1.242, 95% CI: 1.002-1.541, P=0.048) had a higher risk of umbilical cord entanglement than those who were not exposed to passive smoking or noise during pregnancy.  Conclusions  Passive smoking and exposure to noise during pregnancy can affect fetal umbilical cord entanglement. Education during pregnancy should be strengthened to reduce passive smoking and noise exposure during pregnancy.
    • HTML全文

  • 表  1  研究对象的一般特征[n(%)]

    Table  1.   Demographic characteristics of participants [n(%)]

    基线特征 研究对象总体
    (n=6 848)    		 脐带缠绕 χ2值 P值
    是(n=616) 否(n=6 232)
    年龄组(岁) 2.952 0.399
      <25 1 003(14.65) 85(13.80) 918(14.73)
      25~ 3 360(49.07) 297(48.21) 3 063(49.15)
      30~ 1 815(26.50) 162(26.30) 1 653(26.52)
      ≥35 670(9.78) 72(11.69) 598(9.60)
    孕前BMI(kg/m2) 1.198 0.754
      <18.5 902(13.17) 89(14.45) 813(13.04)
      18.5~ 4 348(63.49) 389(63.15) 3 959(63.53)
      24.0~ 1 257(18.36) 110(17.86) 1 147(18.41)
      ≥28.0 341(4.98) 28(4.54) 313(5.02)
    民族 0.111 0.739
      汉族 6 457(94.29) 579(93.99) 5 878(94.32)
      少数民族 391(5.71) 37(6.01) 354(5.68)
    文化程度 13.279 0.004
      初中及以下 937(13.68) 68(11.04) 869(13.95)
      高中 1 482(21.64) 109(17.69) 1 373(22.03)
      大专/本科 4 001(58.43) 393(63.80) 3 608(57.89)
      硕士及以上 428(6.25) 46(7.47) 382(6.13)
    职业
      无业 1 886(27.54) 149(24.19) 1 737(27.87) 5.305 0.070
      脑力劳动 2 483(36.26) 246(39.94) 2 237(35.90)
      体力劳动 2 479(36.20) 221(35.87) 2 258(36.23)
    家庭年收入(万元) 6.765 0.034
      <10 2 244(32.77) 175(28.41) 2 069(33.20)
      10~ 2 623(38.30) 242(39.29) 2 381(38.21)
      ≥20 1 981(28.93) 199(32.30) 1 782(28.59)
    户口类型
      城镇 3 192(46.61) 313(50.81) 2 879(46.20) 4.797 0.029
      农村 3 656(53.39) 303(49.19) 3 353(53.80)
    地区划分1 65.025 < 0.001
      北方 3 736(54.56) 241(39.12) 3 495(56.08)
      南方 3 112(45.44) 375(60.88) 2 737(43.92)
    地区划分2 38.044 < 0.001
      东部 2 599(37.95) 168(27.27) 2 431(39.01)
      中部 2 388(34.87) 273(44.32) 2 115(33.94)
      西部 1 861(27.18) 175(28.41) 1 686(27.05)
    下载: 导出CSV

    表  2  孕妇孕期环境暴露因素[n(%)]

    Table  2.   Environmental exposure factors of pregnant women during pregnancy[n(%)]

    变量 研究对象总体
    (n=6 848)    		 脐带缠绕 χ2值 P值
    是(n=616) 否(n=6 232)
    被动吸烟 8.393 0.015
      无 3 891(56.82) 321(52.11) 3 670(57.28)
      有，但不是每天 2 689(39.27) 275(44.64) 2 414(38.74)
      每天都有 268(3.91) 20(3.25) 248(3.98)
    做饭时未使用排油烟机或排风扇 0.195 0.659
      否 634(9.26) 54(8.77) 580(9.31)
      是 6 214(90.74) 562(91.23) 5 652(90.69)
    居住场所通风情况 1.486 0.223
      较好 1 957(28.58) 163(26.46) 1 794(28.79)
      较差 4 891(71.42) 453(73.54) 4 438(71.21)
    居住或工作场所装修
      否 4 599(67.16) 399(64.77) 4 200(67.39) 1.747 0.186
      是 2 249(32.84) 217(35.23) 2 032(32.61)
    臭水沟 0.373 0.541
      否 6 558(95.77) 587(95.29) 5 971(95.81)
      是 290(4.23) 29(4.71) 261(4.19)
    垃圾站
      否 6 407(93.56) 580(94.16) 5 827(93.50) 0.399 0.528
      是 441(6.44) 36(5.84) 405(6.50)
    噪声 4.723 0.030
      否 5 767(84.21) 500(81.17) 5 267(84.52)
      是 1 081(15.79) 116(18.83) 965(15.48)
    化工厂 0.813 0.367
      否 6 724(98.19) 602(97.73) 6 122(98.23)
      是 124(1.81) 14(2.27) 110(1.77)
    下载: 导出CSV

    表  3  孕妇孕期环境暴露因素[n(%)]

    Table  3.   Environmental exposure factors of pregnant women during pregnancy[n(%)]

    变量 脐带缠绕
    β值 sx Wald χ2值 OR(95% CI)值 P值
    被动吸烟
      无 1.000
      有，但不是每天 0.181 0.087 4.313 1.199(1.010~1.423) 0.038
      每天都有 -0.73 0.241 0.091 0.930(0.579~1.492) 0.762
    做饭时未使用排油烟机或排风扇
      否 1.000
      是 -3.056 0.332 84.564 0.992(0.737~1.334) 0.955
    居住场所通风情况
      较好 1.000
      较差 0.125 0.096 1.669 1.133(0.938~1.268) 0.196
    居住或工作场所装修
      否 1.000
      是 0.100 0.089 1.262 1.106(0.928~1.317) 0.261
    臭水沟
      否 1.000
      是 0.222 0.203 1.199 1.248(0.839~1.857) 0.274
    垃圾站
      否 1.000
      是 -0.103 0.181 0.324 0.902(0.633~1.286) 0.569
    噪声
      否 1.000
      是 0.217 0.110 3.899 1.242(1.002~1.541) 0.048
    化工厂
      否 1.000
      是 0.266 0.290 0.843 1.305(0.739~2.304) 0.359
        注：调整了孕妇的文化程度、家庭年收入、户口类型和地区。
    下载: 导出CSV
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  • 收稿日期:  2020-12-30
  • 修回日期:  2021-01-07
  • 刊出日期:  2021-02-10

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