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江苏省扬中市食管癌高危人群危险因素及其聚集性

冯祥 宋统球 钱东福 周琴 施爱武 魏文强 周金意 华召来

冯祥, 宋统球, 钱东福, 周琴, 施爱武, 魏文强, 周金意, 华召来. 江苏省扬中市食管癌高危人群危险因素及其聚集性[J]. 中华疾病控制杂志, 2021, 25(3): 317-322. doi: 10.16462/j.cnki.zhjbkz.2021.03.013
引用本文: 冯祥, 宋统球, 钱东福, 周琴, 施爱武, 魏文强, 周金意, 华召来. 江苏省扬中市食管癌高危人群危险因素及其聚集性[J]. 中华疾病控制杂志, 2021, 25(3): 317-322. doi: 10.16462/j.cnki.zhjbkz.2021.03.013
FENG Xiang, SONG Tong-qiu, QIAN Dong-fu, ZHOU Qin, SHI Ai-wu, WEI Wen-qiang, ZHOU Jin-yi, HUA Zhao-lai. Current status and clustering analysis of risk factors in high-risk groups of esophageal cancer in Yangzhong City, Jiangsu Province[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(3): 317-322. doi: 10.16462/j.cnki.zhjbkz.2021.03.013
Citation: FENG Xiang, SONG Tong-qiu, QIAN Dong-fu, ZHOU Qin, SHI Ai-wu, WEI Wen-qiang, ZHOU Jin-yi, HUA Zhao-lai. Current status and clustering analysis of risk factors in high-risk groups of esophageal cancer in Yangzhong City, Jiangsu Province[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(3): 317-322. doi: 10.16462/j.cnki.zhjbkz.2021.03.013

江苏省扬中市食管癌高危人群危险因素及其聚集性

doi: 10.16462/j.cnki.zhjbkz.2021.03.013
基金项目: 

国家重点研发计划 National Key Research and Development Program of China

国家重点研发计划 2016YFC1302800

中国消化道早癌医师共同成长计划 GTCZ-2020-JS-32-0003

镇江市社会发展指导性科技计划项目 FZ2020023

详细信息
    通讯作者:

    HUA Zhao-lai, E-mail: 75545075@qq.com

  • 中图分类号: R735.1;R73-31

Current status and clustering analysis of risk factors in high-risk groups of esophageal cancer in Yangzhong City, Jiangsu Province

Funds: 

National Key Research and Development Program of China National Key Research and Development Program of China

National Key Research and Development Program of China 2016YFC1302800

Joint Growth Plan for Chinese Doctors of Early Gastrointestinal Cancer GTCZ-2020-JS-32-0003

Guiding Science and Technology Plan Project of Social Development in Zhenjiang City FZ2020023

  • 摘要:   目的  分析江苏省扬中市食管癌高危人群危险因素流行、聚集现状并探讨危险因素聚集的影响因素。  方法  以上消化道癌早诊早治及食管癌专病队列项目为依托,运用多阶段分层整群抽样的方法,抽取扬中市2 591名40~69岁高危人群进行一对一式面访调查,采用单因素Logistic回归分析模型及多因素Logistic回归分析模型探讨危险因素聚集的影响因素。  结果  扬中市食管癌高危人群吸烟、饮酒、烫热饮食摄入、进食过快、室内空气污染、牙齿缺失和危险因素聚集的流行率分别为22.27%、17.79%、16.79%、26.94%、18.45%、32.15%和40.22%。最常见的危险因素聚集模式为室内空气污染+牙齿缺失、吸烟+饮酒和进食过快+牙齿缺失。多因素Logistic回归分析模型分析显示,在男性、年龄大、文化程度低和农村高危人群中危险因素聚集性较高(均有P < 0.05)。  结论  扬中市食管癌高危人群中部分危险因素暴露还处于较高水平且危险因素存在明显的聚集,男性、年龄大、文化程度低和农村地区居民是食管癌防控的重点人群。
  • 表  1  扬中市食管癌高危人群一般特征[n(%)]

    Table  1.   General characteristics of high-risk groups of esophageal cancer in Yangzhong [n(%)]

    特征 男性 女性 合计
    年龄组(岁)
      40~ 272(23.88) 349(24.04) 621(23.97)
      50~ 479(42.05) 622(42.84) 1 101(42.49)
      60~69 388(34.06) 481(33.13) 869(33.54)
    婚姻状况
      已婚 1 105(97.01) 1 330(91.60) 2 435(93.98)
      其他 34(2.99) 122(8.40) 156(6.02)
    文化程度
      小学及以下 288(25.29) 678(46.69) 966(37.28)
      初中 578(50.75) 655(45.11) 1 233(47.59)
      高中 247(21.69) 108(7.44) 355(13.70)
      大专及以上 26(2.28) 11(0.76) 37(1.43)
    职业a
      体力劳动 808(70.94) 833(57.37) 1 641(63.33)
      白领 88(7.73) 30(2.07) 118(4.55)
      其他 243(21.33) 589(40.56) 832(32.11)
    家庭年收入(万元)
       < 3 66(5.79) 116(7.99) 182(7.02)
      3~ 109(9.57) 158(10.88) 267(10.30)
      5~ 178(15.63) 215(14.81) 393(15.17)
      7~ 171(15.01) 207(14.26) 378(14.59)
      9~ 161(14.14) 212(14.60) 373(14.40)
       > 11 454(39.86) 544(37.47) 998(38.52)
    居住地
      城镇 211(18.53) 330(22.73) 541(20.88)
      农村 928(81.47) 1 122(77.27) 2 050(79.12)
    合计 1 139(43.96) 1 452(56.04) 2 591(100.00)
    注:a职业:体力劳动包括农、林、牧、渔劳动者,服务人员和生产工人;白领包括行政管理人员和专业技术人员;其他包括学生,失业,全职家务和退休人员[13]
    下载: 导出CSV

    表  2  扬中市食管癌高危人群6种危险因素聚集现状[n(%)]

    Table  2.   The clustering of 6 risk factors among high-risk groups of esophageal cancer in Yangzhong [n(%)]

    危险因素数量 男性 女性 合计
    0 138(12.12) 538(37.05) 676(26.09)
    1 302(26.51) 571(39.33) 873(33.69)
    2 357(31.34) 298(20.52) 655(25.28)
    3 229(20.11) 44(3.03) 273(10.54)
    4 90(7.90) 1(0.07) 91(3.51)
    5 22(1.93) 0(0.00) 22(0.85)
    6 1(0.09) 0(0.00) 1(0.04)
    ≥2(聚集) 699(61.37) 343(23.62) 1 042(40.22)
    下载: 导出CSV

    表  3  扬中市食管癌高危人群6种危险因素聚集模式

    Table  3.   The clustering pattern of 6 risk factors among high-risk groups of esophageal cancer in Yangzhong

    危险因素数量 吸烟 饮酒 烫热饮食 进食过快 室内空气污染 牙齿缺失 构成比(%)
    2 - - - - + + 14.78
    2 + + - - - - 6.05
    2 - - - + - + 5.76
    3 + + - + - - 3.55
    3 + + + - - - 3.26
    3 + - + + - - 2.98
    4 + + + + - - 2.88
    4 + + + - - + 1.34
    4 + - + + - + 1.06
    5 + + + + - + 1.06
    5 + + + - + + 0.58
    5 + + - + + + 0.19
    5a + + + + + - 0.19
    6 + + + + + + 0.10
    注:列出了各危险因素数量中排名前3位的聚集模式。a5:与顺位第3并列。
    下载: 导出CSV

    表  4  扬中市食管癌高危人群危险因素聚集影响因素Logistic回归分析模型

    Table  4.   Logistic regression analysis of influencing factors for clustering of risk factors in high-risk groups of esophageal cancer in Yangzhong

    因素 聚集(%) 单因素分析 多因素分析
    β OR(95% CI)值 P β OR(95% CI)值 P
    性别
      男 61.37 1.000 1.000
      女 23.62 -1.636 0.195(0.164~0.231) < 0.001 -1.851 0.157(0.129~0.191) < 0.001
    年龄(岁)
      40~ 26.89 1.000 1.000
      50~ 36.69 0.455 1.576(1.270~1.955) < 0.001 0.472 1.604(1.263~2.037) < 0.001
    60~69 54.20 1.169 3.217(2.577~4.017) < 0.001 1.032 2.807(2.120~3.717) < 0.001
    婚姻状况
      其他 44.23 1.000
      已婚 39.96 -0.175 0.839(0.606~1.163) 0.292
    文化程度
      小学及以下 44.72 1.000 1.000
      初中 36.17 -0.356 0.701(0.590~0.832) < 0.001 -0.321 0.725(0.574~0.916) 0.007
      高中 41.69 -0.124 0.884(0.691~1.130) 0.325 -0.443 0.642(0.468~0.881) 0.006
      大专及以上 43.24 -0.060 0.942(0.485~1.827) 0.859 -0.225 0.798(0.377~1.693) 0.557
    职业
      体力劳动 40.1 1.000
      白领 49.15 0.368 1.444(0.993~2.099) 0.054
      其他 39.18 -0.038 0.962(0.811~1.142) 0.661
    家庭年收入(万元)
       < 3 52.2 1.000
      3~ 52.81 0.025 1.025(0.703~1.494) 0.899
      5~ 39.44 -0.517 0.596(0.418~0.850) 0.004
      7~ 40.21 -0.485 0.616(0.431~0.879) 0.008
      9~ 37.53 -0.597 0.550(0.384~0.788) 0.001
       > 11 35.97 -0.665 0.515(0.374~0.707) < 0.001
    居住地
      农村 43.12 1.000 1.000
      城镇 29.21 -0.609 0.544(0.443~0.668) < 0.001 -0.367 0.693(0.548~0.875) 0.002
    下载: 导出CSV
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  • 收稿日期:  2020-08-13
  • 修回日期:  2020-12-17
  • 刊出日期:  2021-03-10

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