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利用TCGA数据库分析胃腺癌组织PLOD3基因表达及其潜在临床应用价值

陈强, 张涛, 汪自然, 吴正升, 杜卫东. 利用TCGA数据库分析胃腺癌组织PLOD3基因表达及其潜在临床应用价值[J]. 中华疾病控制杂志, 2021, 25(10): 1235-1240. doi: 10.16462/j.cnki.zhjbkz.2021.10.022
引用本文: 陈强, 张涛, 汪自然, 吴正升, 杜卫东. 利用TCGA数据库分析胃腺癌组织PLOD3基因表达及其潜在临床应用价值[J]. 中华疾病控制杂志, 2021, 25(10): 1235-1240. doi: 10.16462/j.cnki.zhjbkz.2021.10.022
CHEN Qiang, ZHANG Tao, WANG Zi-ran, WU Zheng-sheng, DU Wei-dong. Expression and clinical significance of PLOD3 in gastric adenocarcinoma, an analysis from TCGA data bank[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(10): 1235-1240. doi: 10.16462/j.cnki.zhjbkz.2021.10.022
Citation: CHEN Qiang, ZHANG Tao, WANG Zi-ran, WU Zheng-sheng, DU Wei-dong. Expression and clinical significance of PLOD3 in gastric adenocarcinoma, an analysis from TCGA data bank[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(10): 1235-1240. doi: 10.16462/j.cnki.zhjbkz.2021.10.022

利用TCGA数据库分析胃腺癌组织PLOD3基因表达及其潜在临床应用价值

doi: 10.16462/j.cnki.zhjbkz.2021.10.022
基金项目: 

国家自然科学基金 81472493

国家自然科学基金 81972472

安徽省转化医学研究院科研基金 2017zhyx37

详细信息
    通讯作者:

    杜卫东,E-mail:weidong.du@ahmu.edu.cn

  • 中图分类号: R181+2;R446;R34

Expression and clinical significance of PLOD3 in gastric adenocarcinoma, an analysis from TCGA data bank

Funds: 

The National Natural Science Foundation of China 81472493

The National Natural Science Foundation of China 81972472

The Scientific Research Foundation of the Institute for Translational Medicine of Anhui Province 2017zhyx37

More Information
  • 摘要:   目的  利用癌症基因组图谱(the cancer genome atlas, TCGA)数据库分析胃腺癌组织中赖氨酸羟化酶3(procollagen-lysine, 2-oxoglutarate 5-dioxygenase, PLOD3)基因表达及其潜在临床价值。  方法  使用UALCAN数据库(http://ualcan.path.uab.edu/)分析TCGA中PLOD3基因在胃腺癌及癌旁组织间表达差异;利用Kaplan-Meier模型分析PLOD3基因表达与胃腺癌患者预后相关性;利用LinkedOmics数据库筛查PLOD3相关基因;应用免疫组织化学验证胃腺癌与癌旁正常胃黏膜组织PLOD3来源与分布差异。  结果  数据库资料表明,胃腺癌组织PLOD3基因表达高于正常胃组织(P<0.001);伴有p53基因突变的胃腺癌患者PLOD3基因表达高于无p53基因突变患者(P<0.001);PLOD3基因表达与胃腺癌患者生存期相关(HR=1.360,95% CI:1.150~1.610,P < 0.001);PLOD3基因表达与AP1S1、LRWD1和SLC12A9等基因表达呈正相关(均有P<0.001),与CGGBP1、ZNF561和MIER1等基因表达呈负相关(均有P<0.001);免疫组化染色结果进一步证实胃腺癌组织PLOD3蛋白表达高于癌旁正常胃黏膜组织(P=0.031)。  结论  PLOD3可能成为评价胃腺癌预后以及胃腺癌靶向治疗的有效新靶点。
  • 图  1  PLOD3基因表达与p53基因突变状态和胃癌患者临床分期的关系

    Figure  1.  Relationship between PLOD3 gene expression and p53 mutation status and clinical stage in patients with gastric adenocarcinoma

    图  2  PLOD3基因表达与胃腺癌患者预后相关性

    Figure  2.  The correlation between the expression of PLOD3 gene and the prognosis of patients with gastric adenocarcinoma

    图  3  PLOD3相关基因分析

    Figure  3.  Analysis of PLOD3 related genes

    图  4  PLOD3蛋白在癌旁正常胃组织和胃腺癌组织内的表达

    Figure  4.  PLOD3 protein expression in normal gastric tissues and gastric adenocarcinoma tissues

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    Zhang XP, Li Y, Yuan CJ, et al. Preliminary screening of prognosis-related genes in gastric cancer based on TCGA database [J]. Chin J Clin Lab Sci, 2019, 37(5): 396-400. DOI: 10.13602/j.cnki.jcls.2019.05.18.
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出版历程
  • 收稿日期:  2020-08-31
  • 修回日期:  2021-04-30
  • 网络出版日期:  2021-11-17
  • 刊出日期:  2021-10-10

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