An analysis of influencing factors of diabetic retinopathy among type 2 diabetic patients: a nested case-control study
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摘要:
目的 探讨2型糖尿病患者中糖尿病视网膜病变(diabetic retinopathy, DR)的影响因素。 方法 以2013-2014年“社区糖尿病综合干预及应用项目”淮安市35岁以上2型糖尿病人群队列为基础,对其开展问卷调查、身体测量,实验室检测,并将随访期间发生DR的1 544人作为病例组,按照性别,年龄(±4岁)随机抽取对照进行1∶1匹配,建立对照组(1 544人)。采用巢式病例对照研究方法,对糖化血红蛋白、糖尿病病程、SBP等DR的影响因素进行Logistic回归分析,计算OR及其95% CI。此外,使用多分类Logistic回归分析模型分析轻中度DR和重度DR的影响因素。 结果 病例组平均年龄为(58.09±8.55)岁,对照组平均年龄为(58.15±8.50)岁,中位随访时间为6年。单因素Logistic回归分析显示胰岛素使用(OR=2.26, 95% CI: 1.75~2.92),高TG(OR=1.06, 95% CI: 1.02~1.11),腰臀比增加(0.1为变化量)(OR=1.28, 95% CI: 1.15~1.43),高糖化血红蛋白(OR=1.65, 95% CI: 1.57~1.73),SBP高(OR=1.01, 95% CI: 1.00~1.01),糖尿病病程长[5-10年vs. < 5年(OR=1.69, 95% CI: 1.42~2.01), ≥10年vs. < 5年(OR=2.38, 95% CI: 1.94~2.91)]是DR发生的危险因素。 结论 胰岛素使用、TG、腰臀比、糖化血红蛋白、SBP和糖尿病病程是2型糖尿病患者发生DR的影响因素。应加强2型糖尿病病人的DR筛查力度。 Abstract:Objective To investigate the influencing factors of diabetic retinopathy (DR) in type 2 diabetic patients. Methods This nested case-control study was based on a prospective cohort study: Comprehensive Research on the Prevention and Control of the Diabetes, including type 2 diabetic patients over 35 years old at communities in Huai'an City in 2013-2014. Standardized questionnaires, anthropometric measurement and biochemical blood tests were used to collect baseline information. For this study, 1 544 patients diagnosed with DR during follow-up were recruited as cases, controls were randomly selected and were 1∶1 matched with case by age (±4 years) and sex. The relationship between DR and glycated hemoglobin, diabetes duration, systolic blood pressure and other influencing factors were analyzed using Logistic regression model. In addition, multinominal Logistic regression was performed to analyze the influencing factors of mild-moderate and severe DR. Results The mean age of cases and controls was (58.09±8.55) and (58.15±8.50) years, respectively, and the median of follow-up was 6 years. Logistic regression model found that insulin use (OR=2.26, 95% CI: 1.75-2.92), triglyceride (OR=1.06, 95% CI: 1.02-1.11), waist-hip ratio (per 0.1-unit increase) (OR=1.28, 95% CI: 1.15-1.43), glycated hemoglobin (OR=1.65, 95% CI: 1.57-1.73), systolic blood pressure (OR 1.01 (95% CI: 1.00-1.01), diabetes duration [5-10 y vs. < 5 y, OR =1.69 (95% CI: 1.42-2.01); ≥10 y vs. < 5 y, OR=2.38, (95% CI: 1.94-2.91)] were associated with the risk of DR. Conclusions Insulin use, triglyceride, waist-hip ratio, glycated hemoglobin, systolic blood pressure and diabetes duration are the influencing factors of DR among type 2 diabetic patients. It is important to strengthen screening for DR among type 2 diabetic patients. -
表 1 参与者基线特征
Table 1. Baseline characteristics of the participants
变量 对照(n= 1 544) 病例(n= 1 544) t/χ2值 P值 男性[n (%)] 545(35.3) 551(35.7) 0.035 b 0.851 降压药使用(%) 618(40.0) 543(35.2) 7.558 b 0.006 c 降脂药使用(%) 134(8.7) 113(7.3) 1.760 b 0.184 文化程度小学及以上(%) 552(36.1) 448(29.2) 16.047 b < 0.001 c 吸烟(%) 319(20.7) 368(23.8) 4.313 b 0.038 c 胰岛素使用(%) 95(6.2) 199(12.9) 39.882 b < 0.001 c 年龄(岁) 58.15±8.50 58.09±8.55 0.177 a 0.859 BMI(kg/m2) 26.10±3.43 26.10±3.48 0.253 a 0.800 腰臀比 0.89±0.07 0.90±0.07 -4.427 a < 0.001 c 糖化血红蛋白(%) 7.12±1.52 8.65±2.08 23.300 a < 0.001 c TC/HDL-C 3.84±1.15 3.91±1.17 -1.775a 0.076 SBP(mm Hg) 143.49±19.93 145.37±20.56 -2.580 a 0.010 c DBP(mm Hg) 83.00±10.46 83.11±11.02 -0.285 a 0.776 糖尿病病程(年) 88.436 b < 0.001 c < 5 1 033(66.9) 788(51.0) 5~ < 10 325(21.0) 419(27.1) ≥10 186(12.0) 337(21.8) TG(mg/dl) 1.95±1.59 2.12±1.82 -2.843 a 0.004 c 注:at检验;bχ2检验; c差异有统计学意义。 表 2 糖尿病视网膜病变影响因素的Logistic回归分析
Table 2. Logistic regression analysis of the influencing factors of diabetic retinopathy
影响因素 单因素分析 多因素分析 β值 OR (95% CI) P值 β值 OR (95% CI) P值 年龄(岁) -0.001 1.00 (0.99~1.01) 0.859 0.001 1.00 (0.99~1.01) 0.776 性别(男/女) 0.017 1.02 (0.88~1.18) 0.821 0.047 1.05 (0.89~1.24) 0.572 胰岛素(使用/不使用) 0.814 2.26 (1.75~2.92) < 0.001 a 0.322 1.38 (1.04~1.84) 0.028 a TG(mmol/L) 0.062 1.06 (1.02~1.11) 0.005 a 0.068 1.07 (1.01~1.14) 0.031 a BMI(kg/m2) -0.003 1.00 (0.98~1.02) 0.800 -0.016 0.98 (0.96~1.01) 0.228 腰臀比(0.1个变化量) 0.245 1.28 (1.15~1.43) < 0.001 a 0.21 1.23 (1.08~1.41) 0.002 a 糖化血红蛋白(%) 0.498 1.65 (1.57~1.73) < 0.001 a 0.47 1.60 (1.52~1.69) < 0.001 a SBP(mm Hg) 0.005 1.01 (1.00~1.01) 0.010 a 0.006 1.01 (1.00~1.01) 0.002 a 糖尿病病程(年) < 5 参照 参照 ― 参照 ― 5~ < 10 0.525 1.69 (1.42~2.01) < 0.001 a 0.207 1.23 (1.01~1.49) 0.036 a ≥10 0.865 2.38 (1.94~2.91) < 0.001 a 0.354 1.42 (1.13~1.80) 0.003 a 降脂药(使用/不使用) -0.185 0.83 (0.64~1.08) 0.164 -0.218 0.80 (0.60~1.07) 0.142 TC/HDL-C 0.055 1.06 (0.99~1.12) 0.076 -0.098 0.91 (0.82~0.99) 0.043 a 注:a差异有统计学意义。 表 3 糖尿病视网膜病变严重程度的多分类Logistic回归分析结果
Table 3. Multinominal Logistic regression analysis of the severity of diabetic retinopathy
影响因素 轻-中度DR (n= 1 238) 重度DR (n=306) OR (95% CI) P值 OR (95% CI) P值 年龄(岁) 1.00 (0.99~1.01) 0.786 1.02 (0.99~1.03) 0.057 性别(男/女) 1.11 (0.94~1.32) 0.214 0.77 (0.58~1.03) 0.079 胰岛素(使用/不使用) 1.31 (0.97~1.76) 0.075 1.70 (1.13~2.56) 0.011 a TG(mmol/L) 1.07 (1.01~1.14) 0.032 a 1.06 (0.69~1.17) 0.249 BMI(kg/m2) 0.99 (0.96~1.02) 0.406 0.96 (0.92~1.01) 0.103 腰臀比(0.1个变化量) 1.22 (1.06~1.40) 0.006 a 1.33 (1.06~1.66) 0.014 a 糖化血红蛋白(%) 1.56 (1.48~1.64) < 0.001 a 1.81 (1.68~1.94) < 0.001 a SBP(mm Hg) 1.01 (1.00~1.02) 0.001 a 1.00 (0.99~1.01) 0.677 糖尿病病程(年) < 5 参照 ― 参照 ― 5~ < 10 1.16 (0.95~1.42) 0.151 1.65 (1.20~2.26) 0.002 a ≥10 1.35 (1.06~1.72) 0.014 a 1.83 (1.27~2.62) 0.001 a 降脂药(使用/不使用) 0.82 (0.60~1.10) 0.186 0.75 (0.45~1.27) 0.290 TC/HDL-C 0.90 (0.81~0.99) 0.029 a 0.96 (0.82~1.13) 0.628 注:a差异有统计学意义。 -
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