高原地区青中年人群睡眠与慢性病共病的关联

李亚杰; 何瑞峰; 索朗德吉; 旺青平措; 次仁卓嘎; 拉巴次仁; 四郎央宗; 尼玛曲措

doi:10.16462/j.cnki.zhjbkz.2022.03.006

高原地区青中年人群睡眠与慢性病共病的关联

doi: 10.16462/j.cnki.zhjbkz.2022.03.006

850000 拉萨，西藏自治区疾病预防控制中心慢病所

基金项目:

国家重点研发计划 2017YFC0907300

国家重点研发计划 2017YFC0907302

详细信息

通讯作者:
尼玛曲措，E-mail：1084790417@qq.com

中图分类号: R749.4
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- 被引次数: 0
出版历程
- 收稿日期: 2021-01-20
- 修回日期: 2021-07-24
- 网络出版日期: 2022-03-17
- 刊出日期: 2022-03-10

Association of sleep with chronic comorbidities of young and middle-aged people in a plateau area

Institute of Non-communicable Diseases Prevention and Control, Tibet Center for Disease Control and Prevention, Lhasa 850000, China

Funds:

National Key Research and Development Program of china 2017YFC0907300

National Key Research and Development Program of china 2017YFC0907302

More Information

Corresponding author: NIMA Qu-cuo, E-mail: 1084790417@qq.com

摘要

摘要: 目的探讨高原地区青中年人群睡眠时长、睡眠质量、睡眠打鼾和慢性病共病的关联。方法 2018年5月―2019年8月采用多阶段随机整群抽样方法抽取拉萨市城关区30岁及以上人群进行问卷调查，采用多因素Logistic回归分析模型分析睡眠与慢性病共病之间的相关性。结果共纳入5 505名30~ < 60岁青中年人，年龄为(44.70±8.50)岁，慢性病共病者占29.5%。多因素Logistic回归分析模型显示，在调整潜在混杂因素后，睡眠时长过短、睡眠质量差和睡眠打鼾是青中年人群慢性病共病的危险因素。与睡眠时长8 h相比，睡眠时长≤6 h者慢性病共病的OR值为1.57(95% CI: 1.21~2.04)；与睡眠质量好者相比，睡眠质量差者慢性病共病的OR值为1.59(95% CI: 1.39~1.82)；与睡眠时不打鼾者相比，睡眠时偶尔打鼾和经常打鼾者慢性病共病的OR值为1.20(95% CI: 1.02~1.41)和1.64(95% CI: 1.37~1.97)。结论睡眠时长过短(≤6 h)、睡眠质量差和睡眠打鼾与高原地区青中年人群慢性病共病风险相关。高原地区青中年人群不仅要保证适宜的睡眠时间，而且要控制睡眠打鼾行为，提高睡眠质量。
- 共病 /
- 慢性病 /
- 睡眠时长 /
- 睡眠质量 /
- 青年人 /
- 中年人
Abstract: Objective To investigate the relationship of sleep duration, sleep quality, and snoring with chronic comorbidities in young and middle-aged people at high altitude. Methods From May 2018 to August 2019, people aged 30 and above in Chengguan District of Lhasa City were selected by multi-stage random cluster sampling method for questionnaire survey. Multivariate Logistic regression model was used to analyze the correlation between sleep and chronic comorbidities. Results A total of 5 505 young and middle-aged people aged 30-59 years old were included in the study. The average age was (44.70 ± 8.50) years old, and 29.5% of them were defined with chronic comorbidities. Multivariate Logistic regression models showed that shorter sleep duration, poor sleep quality, and snoring were risk factors for chronic comorbidities in young and middle-aged people after adjusting for potential confounding factors. Compared with participants with 8 hours of sleep duration daily, the OR (95% CI) of chronic comorbidities for those with sleep duration ≤6 h was 1.57(95% CI: 1.21-2.04). The OR (95% CI) of chronic comorbidities was 1.59(95% CI: 1.39-1.82) in the poor sleep quality group compared with those with good sleep quality. Compared with those who did not snore during sleep, the OR (95% CI) of chronic comorbidities in those who snored occasionally and frequently during sleep were 1.20 (95% CI: 1.02-1.41) and 1.64 (95% CI: 1.37-1.97), respectively. Conclusions Shorter sleep duration (≤6 h), poor sleep quality, and snoring are associated with chronic comorbidities in young and middle-aged people at high altitude. The middle-aged people in plateau area should not only ensure the proper sleep time, but also control the snoring behavior and improve the sleep quality.
- Comorbidities /
- Chronic diseases /
- Sleep duration /
- Sleep quality /
- Young people /
- Middle-aged people

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图 1 青中年睡眠时长和睡眠质量联合效应与慢性病共病关联的Logistic回归分析模型分析

注：调整年龄、性别、受教育程度、婚姻状况、职业、家庭年收入、吸烟、饮酒、体力活动、睡眠打鼾、社会支持和自评健康。

Figure 1. Logistic regression model of the combined effect of sleep duration and sleep quality and chronic diseases

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表 1 调查对象基本特征[n (%)]

Table 1. Basic characteristics of participants [n (%)]

变量	共病(n=1 624)	非共病(n=3 881)	合计(n=5 505)	χ²值	P值	变量	共病(n=1 624)	非共病(n=3 881)	合计(n=5 505)	χ²值	P值
性别				39.116	＜0.001	体力活动				0.339	0.560
男	558(34.4)	1 686(43.3)	2 244(40.8)			低	802(49.4)	1 950(50.2)	2 752(50.0)
女	1 066(65.6)	2 195(56.6)	3 261(59.2)			高	822(50.6)	1 931(49.8)	2 753(50.0)
年龄组(岁)				266.335	＜0.001	自评健康				338.441	＜0.001
30~＜45	498(30.7)	2 125(54.8)	2 623(47.6)			非常好	73(4.5)	421(10.8)	494(9.0)
45~＜60	1 126(69.3)	1 756(45.2)	2 882(52.4)			较好	732(45.1)	2 400(61.8)	3 132(56.9)
家庭年收入(万元)				7.829	0.050	一般	616(37.9)	920(23.7)	1 536(27.9)
＜1.2	381(23.5)	787(20.3)	1 168(21.2)			较差	189(11.6)	135(3.5)	324(5.9)
1.2~＜2	467(28.8)	1 145(29.5)	1 612(29.3)			非常差	14(0.9)	5(0.1)	19(0.3)
2~＜6	530(32.6)	1 365(35.2)	1 895(34.4)			社会支持				30.603	＜0.001
≥6	246(15.1)	584(15.0)	830(15.1)			低	557(34.3)	1 043(26.9)	1 600(29.1)
受教育程度				44.941	＜0.001	高	1 067(65.7)	2 838(73.1)	3 905(70.9)
未正规上过学	921(56.7)	1 846(47.6)	2 767(50.3)			睡眠时长(h)				30.799	＜0.001
小学	504(31.0)	1 347(34.7)	1 851(33.6)			≤6	133(8.2)	181(4.7)	314(5.7)
初中及以上	199(12.3)	688(17.7)	887(16.1)			7	235(14.5)	554(14.3)	789(14.3)
婚姻状况				7.498	0.006	8	831(51.2)	2 104(54.2)	2 935(53.3)
已婚	1 440(88.7)	3 534(91.1)	4 974(90.4)			9	262(16.1)	697(18.0)	959(17.4)
未婚/丧偶/离异	184(11.3)	347(8.9)	531(9.6)			≥10	163(10.0)	345(8.9)	508(9.2)
职业				86.728	＜0.001	睡眠质量				134.594	＜0.001
在业	667(41.1)	2 128(54.8)	2 795(50.8)			好	934(57.5)	2 849(73.4)	3 783(68.7)
无业/退休	957(58.9)	1 753(45.2)	2 710(49.2)			差	690(42.5)	1 032(26.6)	1 722(31.3)
吸烟				56.300	＜0.001	睡眠打鼾				14.471	0.001
不吸烟	1 277(78.6)	2 756(71.0)	4 033(73.3)			经常	297(18.3)	555(14.3)	852(15.5)
现在吸烟	259(15.9)	970(25.0)	1 229(22.3)			偶尔	327(20.1)	785(20.2)	1 112(20.2)
过去吸烟	88(5.4)	155(4.0)	243(4.4)			无	1 000(61.6)	2 541(65.6)	3 541(64.3)
饮酒				29.831	＜0.001
从不饮酒	1 161(71.5)	2 478(63.8)	3 639(66.1)
偶尔饮酒	361(22.2)	1 093(28.2)	1 454(26.4)
经常饮酒	102(6.3)	310(8.0)	412(7.5)

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表 2 青中年睡眠与慢性病共病关联的Logistic回归分析模型分析结果

Table 2. Results of Logistic regression analysis model for the association of sleep and chronic diseases in young and middle age

睡眠状况	模型1		模型2		模型3
睡眠状况	OR(95% CI)值	P值	OR(95% CI)值	P值	OR(95% CI)值	P值
睡眠时长(h)
8	1.00		1.00		1.00
≤6	1.66(1.29~2.14)	＜0.001	1.68(1.30~2.16)	＜0.001	1.57(1.21~2.04)	0.001
7	1.07(0.89~1.28)	0.454	1.07(0.89~1.29)	0.453	1.09(0.90~1.31)	0.378
9	0.94(0.79~1.12)	0.493	0.94(0.79~1.11)	0.440	0.93(0.78~1.11)	0.440
≥10	1.25(1.01~1.55)	0.039	1.24(1.00~1.54)	0.051	1.21(0.97~1.51)	0.093
睡眠质量
好	1.00		1.00		1.00
差	1.74(1.53~1.98)	＜0.001	1.73(1.52~1.97)	＜0.001	1.59(1.39~1.82)	＜0.001
睡眠打鼾
无	1.00		1.00		1.00
偶尔	1.13(0.96~1.32)	0.141	1.15(0.98~1.34)	0.094	1.20(1.02~1.41)	0.032
经常	1.65(1.38~1.96)	＜0.001	1.68(1.41~2.00)	＜0.001	1.64(1.37~1.97)	＜0.001
注：模型1：调整年龄和性别；模型2：在模型1的基础上调整受教育程度、婚姻状况、职业和家庭年收入；模型3：在模型2的基础上调整吸烟、饮酒、体力活动、社会支持和自评健康。

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