COVID-19疫情下肺结核病人的COVID-19疫苗接种策略

王远舟; 贾斯月; 朱凤才; 李靖欣

doi:10.16462/j.cnki.zhjbkz.2022.11.018

COVID-19疫情下肺结核病人的COVID-19疫苗接种策略

doi: 10.16462/j.cnki.zhjbkz.2022.11.018

王远舟¹,
贾斯月²,
朱凤才¹,
李靖欣^{1, 2, ,}

1.
211166 南京, 南京医科大学公共卫生学院
2.
210009 南京, 江苏省疾病控制预防中心疫苗临床评价所

基金项目:

国家自然科学基金 82173584

详细信息

通讯作者:
李靖欣, E-mail: jingxin42102209@126.com

中图分类号: R18
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- 文章访问数: 324
- HTML全文浏览量: 193
- PDF下载量: 35
- 被引次数: 0
出版历程
- 收稿日期: 2022-04-11
- 修回日期: 2022-07-03
- 网络出版日期: 2022-12-21
- 刊出日期: 2022-11-10

Strategy for COVID-19 vaccination for patients with tuberculosis during the COVID-19 pandemic

1.
School of Public Health, Nanjing Medical University, Nanjing 211166, China
2.
Department of Vaccine Clinical Evaluation, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China

Funds:

National Natural Science Foundation of China 82173584

More Information

Corresponding author: LI Jing-xin, E-mail: jingxin42102209@126.com

摘要

摘要: COVID-19疫情流行形势依旧严峻，对于疫苗的普及接种刻不容缓。肺结核是中国高发的慢性传染病，由于病发肺部，肺结核患者合并感染COVID-19之后病情更重，治疗效果差。而目前对于肺结核患者接种COVID-19疫苗的保护效力、免疫原性及安全性仍知之甚少，也缺乏相应的循证医学证据。本文回顾了肺结核的发病机制与流行病学，探讨了肺结核患者体内的免疫状态，对目前国内外已有的对肺结核患者疫苗接种的提议进行了总结，同时结合其他特殊人群已有的疫苗接种的临床研究进行分析，探讨了COVID-19疫情下肺结核病人的疫苗接种策略和开展以肺结核患者为目标人群的COVID-19疫苗临床研究的必要性。
- 新型冠状病毒 /
- COVID-19 /
- 肺结核 /
- 疫苗接种 /
- 灭活疫苗 /
- 临床试验
Abstract: The pandemic of COVID-19 is still rampaging all over the world, so it is urgent to popularize vaccination. Meanwhile, pulmonary tuberculosis is one of the chronic infectious diseases with a high incidence in China. Since these diseases all occur in lung tissue, patients with TB and COVID-19 co-infection show more serious conditions and poorer treatment effects. However, we have limited knowledge about the protective efficacy, immunogenicity and safety of COVID-19 vaccine in patients with TB at present, with a lack of corresponding evidence-based medicine as well. Therefore, this paper reviews the pathogenesis and epidemiology of TB, discusses the immune status of patients with TB and summarizes the existing proposals for vaccination of patients with TB at home and abroad. Furthermore, we analyze the existing clinical trials in TB patients and other special populations, and finally discuss the strategy of vaccination for patients with TB during the COVID-19 pandemic and the necessity of clinical research on COVID-19 vaccines with target population of TB patients.
- SARS-CoV-2 /
- COVID-19 /
- Pulmonary tuberculosis /
- Vaccination /
- Inactivated vaccine /
- Clinical trial

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参考文献(38)

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