中老年人群肺通气功能及其影响因素研究

林建维; 李春玲; 崔旭初; 靳桂才; 逄增昌

doi:10.16462/j.cnki.zhjbkz.2016.02.017

中老年人群肺通气功能及其影响因素研究

doi: 10.16462/j.cnki.zhjbkz.2016.02.017

1. 赤峰市疾病预防控制中心公共卫生科, 内蒙古赤峰 024000;
2. 青岛市疾病预防控制中心老化研究项目组, 山东青岛 266033

基金项目:

国际合作项目丹麦科学技术和创新基金2009（08-045167）；山东省科学技术研究（2010G0020247）

详细信息

作者简介:
林建维(1981-),女,内蒙古赤峰人,主管医师,博士。主要研究方向:营养流行病学。

中图分类号: R181.2;R331.372
计量
- 文章访问数: 386
- HTML全文浏览量: 54
- PDF下载量: 59
- 被引次数: 0
出版历程
- 收稿日期: 2015-10-14
- 修回日期: 2015-12-15

Analysis on pulmonary ventilation function and its influencing factors in the elderly population

1. Public Health Section, Chifeng Municipal Center for Disease Control and Prevention, Chifeng 024000, China;
2. Aging Research Team, Qingdao Municipal Center for Disease Control and Prevention, Qingdao 266033, China

摘要

摘要: 目的探讨社会人口学和血生化指标对青岛地区50～74岁中老年人群的第1秒肺通气量（forced expiratory volumne in 1 second, FEV₁）和最大肺通气量（the largest force vital capacity, FVC）的影响。方法采用分层整群抽样方法，2009年在青岛市区及农村抽取50～74岁居民 2 476 人，用自制量表进行调查，同时检测其FEV₁、FVC和血生化指标。采用多元线性回归分析了年龄、性别、收入、教育、体质指数、糖化血红蛋白（glycosylated hemoglobin,HbA1c）、总胆固醇（total cholesterol,TC）与高密度脂蛋白胆固醇（high density lipoprotein cholesterol,HDL-C）比值（TC/HDL-C）和尿酸（uric acid,UA）对肺通气功能的影响。结果男性的FEV₁和FVC均高于女性。随着年龄增加，FEV₁和FVC均出现下降，且在65～69段下降出现了加速。随着受教育（β=0.433，P=0.042）和BMI水平（β=0.776，P<0.001）升高，FEV₁也呈逐渐升高趋势。随着HbA1c的升高，FEV₁（β=-0.254，P<0.001）和FVC（β=-0.298，P=0.046）均呈下降趋势，但随着TC/HDL-C的升高，FEV₁和FVC又呈升高趋势。UA与FEV₁和FVC之间均无显著性相关。结论 FEV₁和FVC的下降是多因素作用的结果，其中年龄和HbA1c是其危险因素，而收入、教育、BMI和血脂是其保护因素。
- 老年人 /
- 肺通气 /
- 最大通气量
Abstract: Objective To investigate the effect of socio-demographic and blood biochemical indicators on forced expiratory volumne in1second (FEV₁) and the largest force vital capacity(FVC) of 50-74 year-old residents in Qingdao. Methods 2 476 Qingdao rural and urban residents who aged 50-74 years were sampled through stratified cluster sampling method in 2009. Homemade scale was adopted to interview the elderly, meanwhile, FEV₁, FVC and blood biochemical indicators were measured. Multiple linear regression analysis was used to investigate the effect of age, gender, income, education, body mass index, glycosylated hemoglobin (HbA1C), blood lipids (TC/HDL-C) and uric acid (UA) on pulmonary ventilation function. Results Males were better than females in FEV₁ and FVC. With increasing age, FEV₁ and FVC were both declined, and the descend was larger in 65-69 group. With increasing education(β=0.433,P=0.042) and BMI(β=0.776,P<0.001), FEV₁ showed a rising trend. With increasing HbA1c, FEV₁ (β=-0.254,P<0.001)and FVC(β=-0.298,P=0.046) were decreased, while with increasing TC/HDL-C, FEV₁ and FVC showed a rising trend. There were no significant correlation between UA with FEV₁ and FVC. Conclusions The decrease of FEV₁ and FVC are the result of interactions of multiple factors, age and HbA1c are risk factors, while income, education, BMI and blood lipids are protective factors.
- Elderly /
- Pulmonary ventilation /
- Maximal voluntary ventilation

HTML全文

参考文献(16)

Macsali F, Svanes C, Björge L, et al. Respiratory health in women: from menarche to menopause [J]. Expert Rev Respir Med, 2012,6(2):187-200.

Oksuzyan A, Crimmins E, Saito Y, et al. Cross-national comparison of sex differences in health and mortality in Denmark, Japan and the US [J]. Eur J Epidemiol, 2010, 25(7):471-480.

Kaneda T, Zimmer Z, Fang X, et al. Gender differences in functional health and mortality among the Chinese elderly: testing an exposure versus vulnerability hypothesis [J]. Res Aging, 2009,31(3):361-388.

Nakadate T. Age-related decline in forced expiratory volume in one second and forced vital capacity based on a longitudinal observation of Japanese males [J]. Nihon Kyobu Shikkan Gakkai Zasshi, 1997,35(9):954-959.

Lasheras C, Patterson AM, Casado C, et al. Effects of education on the quality of life, diet, and cardiovascular risk factors in an elderly Spanish community population [J]. Experimental Aging Research, 2001,27(3):257-270.

Maiolo C, Mohamed EI, Carbonelli MG. Body composition and respiratory function [J]. Acta Diabetol, 2003,40 Suppl 1(1 Supplement):s32-s38.

雷玲,钟小宁,何志义,等. 低体质指数的慢性阻塞性肺疾病患者临床和实验室研究 [J]. 中华老年医学杂志, 2008,27(8):575-578.

Li AM, Chan D, Wong E, et al. The effects of obesity on pulmonary function [J].Arch Dis Child, 2003,88(4):361-363.

Fuso L, Pitocco D, Condoluci C, et al. Decline of the lung function and quality of glycemic control in type 2 diabetes mellitus [J]. Eur J Intern Med, 2015,26(4):273-278.

Uz-Zaman S, Banerjee J, Singhamahapatra A, et al. Assessment of lung function by spirometry and diffusion study and effect of glycemic control on pulmonary function in type 2 diabetes mellitus patients of the eastern India [J]. J Clin Diagn Res, 2014,8(11):BC01-4.

谢坤,张晓庆. 住院2型糖尿病合并抑郁症患者生命质量的相关性研究 [J]. 中华疾病控制杂志, 2014,18(6):515-517.

Shah SH, Sonawane P, Nahar P, et al. Pulmonary function tests in type 2 diabetes mellitus and their association with glycemic control and duration of the disease [J]. Lung India, 2013,30(2):108-112.

Davis WA, Knuiman M, Kendall P, et al. Glycemic exposure is associated with reduced pulmonary function in type 2 diabetes, the fremantle diabetes study [J]. Diabetes Care, 2004,27(3):752-757.

Sinha S, Guleria R, Misra A, et al. Pulmonary functions in patients with type 2 diabetes mellitus and correlation with anthropometry and microvascular complications [J]. Indian J Med Res, 2004,119(2):66-71.

余丽莎,孙晓红,马黔平,等. 贵州省少数民族地区部分成人高尿酸血症的相关因素分析 [J].中华疾病控制杂志, 2015,19(5):443-446.

Wu XW, Muzny DM, Lee CC, et al. Two independent mutational events in the loss of urate oxidase during hominoid evolution [J]. J Mol Evol, 1992,34(1):78-84.

施引文献

资源附件(0)

访问统计