连云港农村地区男性高血压人群中饮酒与血脂的相关性分析

於涛; 王雯; 王力炜; 杨文彬; 王滨燕; 唐根富; 臧桐华; 秦献辉; 王玉; 李建平; 霍勇; 徐希平

doi:10.16462/j.cnki.zhjbkz.2016.04.012

连云港农村地区男性高血压人群中饮酒与血脂的相关性分析

doi: 10.16462/j.cnki.zhjbkz.2016.04.012

1. 安徽医科大学生物医学研究所, 安徽合肥 230032;
2. 南方医科大学南方医院国家肾脏病临床医学研究中心, 广东广州 510515;
3. 北京大学第一医院心内科, 北京 100034

基金项目:

国家自然科学基金（81473052）；“十二五”国家重大新药创制专项（2012ZX09101105）

详细信息

作者简介:
於涛(1989-),女,安徽合肥人,在读硕士研究生。主要研究方向:慢性病流行病学。

中图分类号: R544.1;R181
计量
- 文章访问数: 320
- HTML全文浏览量: 84
- PDF下载量: 27
- 被引次数: 0
出版历程
- 收稿日期: 2015-11-13
- 修回日期: 2016-01-04

The relationship of alcohol drinking with serum lipid levels in Lianyungang rural male adults with hypertension

1. Institute of Biomedicine, Anhui Medical University, Hefei 230032, China;
2. National Clinical Research Center for Kidney Disease, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;
3. Department of Cardiology, Peking University First Hospital, Beijing 100034, China

摘要

摘要: 目的探讨连云港农村地区男性高血压人群中饮酒状态与血脂的关系及其影响因素。方法 2008年5月在连云港农村地区进行流行病学调查，通过问卷调查收集受试者的饮酒状况和其他相关变量，实验室检测血清总胆固醇（total cholesterol，TCHO）、甘油三酯（triglyceride，TG）、高密度脂蛋白（high density lipoprotein，HDL-C），由Friedewald公式计算低密度脂蛋白（low density lipoprotein，LDL-C），采用多元线性回归评估饮酒与血脂指标的关联。结果 5 574名男性受试者纳入分析。调整年龄、体质指数、血压、血糖、吸烟、体力劳动强度后，与不饮酒者相比，现在饮酒者的总胆固醇（β=15.58，s_x^-=1.30，P<0.001）、高密度脂蛋白（β=8.01，s_x^-=0.43，P<0.001）、低密度脂蛋白（β=7.71，s_x^-=1.17，P<0.001）水平差异有统计学意义，甘油三酯（β=-0.71，s_x^-=1.88，P=0.704）组间差异无统计学意义。在糖尿病人群中，饮酒与总胆固醇（与非糖尿病人群比较，交互作用P<0.001）、低密度脂蛋白（与非糖尿病人群比较，交互作用P=0.001）升高具有更强的关联。结论现在饮酒与总胆固醇、高密度脂蛋白、低密度脂蛋白水平呈显著正相关，与甘油三酯差异无统计学意义。
- 饮酒 /
- 血脂异常 /
- 高血压
Abstract: Objective To investigate the association between alcohol drinking and blood lipid levels as well as the influencing factors in Lianyungang rural male adults with hypertension. Methods An epidemiological investigation was conducted in May 2008 in rural areas of Lianyungang.Baseline data collection, including alcohol drinking status, was conducted by trained research staff using a standardized questionnaire designed specifically for the study. Serum total cholesterol(TCHO), triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) were measured using automatic clinical analyzers (Beckman Coulter). Low-density lipoprotein cholesterol (LDL-C) was estimated by the Friedewald formula.Multivariate linear regression models were applied to evaluate the relation between alcohol drinking status and blood lipid levels. Results A total of 5 574 male participants were included in the final analysis.After adjustment for age, body mass index, blood pressure, fasting glucose, smoking and physical activity levels, compared to never alcohol drinkers, current alcohol drinkers showed significantly increased concentrations of serum TCHO(β=15.58,s_x^-=1.30,P<0.001), HDL-C(β=8.01,s_x^-=0.43, P<0.001)and LDL-C(β=7.71,s_x^-=1.17,P<0.001), but had no significant effect on the TG levels (β=-0.71, s_x^-=1.88, P=0.704). Furthermore, a greater association between alcohol assumption and the increase of TCHO (versus participants without diabetes, P for interaction <0.001) or LDL-C (versus participants without diabetes, P for interaction=0.001) levels was observed in participants with diabetes. Conclusions Alcohol drinking was significantly associated with increased total cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol levels. There was no significant association between alcohol drinking and the level of triglyceride.
- Alcohol drinking /
- Blood lipid abnormality /
- Hypertension

HTML全文

参考文献(14)

World Health Organization. The World Health Report 2014, Global Status ReportOn Alcohol And Health [M]. Geneva:World Health Organization Document, 2014

刘扬,赵莉. 饮酒对血脂的影响及与脑血管病的关系 [J]. 吉林医学, 2008,29(21):1885-1886.

丁昱,罗静,崔伟,等. 中国农村地区人群吸烟状态与血脂的相关性分析 [J]. 中华疾病控制杂志, 2015,19(6):559-563.

陈伟伟,高润霖,刘力生,等. 《中国心血管报告2014》概要 [J]. 中国循环杂志, 2015,30(7):617-622.

中国成人血脂异常防治指南制订联合委员会. 中国成人血脂异常防治指南 [J]. 中华心血管病杂志, 2007,35(5):390-419.

Pownall HJ. Alcohol: lipid metabolism and cardioprotection [J]. Curr Atheroscler Rep, 2002,4(2):107-112.

Wakabayashi I. Associations between heavy alcohol drinking and lipid-related indices in middle-aged men[J].Alcohol, 2013,47(8):637-642.

陈大尧,秦文喜. 饮酒对血脂影响的调查研究 [J]. 中国预防医学杂志, 2001,2(4):291-292.

De Oliveira E Silva ER, Foster D, McGee Harper M, et al. Alcohol consumption raises HDL cholesterol levels by increasing the transport rate of apolipoproteins A-I and A-II [J]. Circulation, 2000,102(19):2347-2352.

Chung BH, Doran S, Liang P, et al. Alcohol-mediated enhancement of postprandial lipemia: a contributing factor to an increase in plasma HDL and a decrease in risk of cardiovascular disease [J]. Am J Clin Nutr, 2003,78(3):391-399.

Park H, Kim K. Association of alcohol consumption with lipid profile in hypertensive men [J]. Alcohol Alcohol, 2012,47(3):282-287.

谢屹,王雪. 长期饮酒与血压、血脂和血糖的关系 [J]. 华西医学, 2008,23(6):1513-1514.

Zhang L, Qiao Q, Tuomilehto J, et al. Blood lipid levels in relation to glucose status in seven populations of Asian origin without a prior history of diabetes: the DECODA study [J]. Diabetes Metab Res Rev, 2009,25(6):549-557.

Shimomura T, WakabayashiI. Inverse associations between light-to-moderate alcohol intake and lipid-related indices in patients with diabetes [J]. Cardiovasc Diabetol, 2013,17(12):104-112.

施引文献

资源附件(0)

访问统计