A case-control study on influencing factors for the risk of systemic sclerosis among women
-
摘要: 目的 探讨月经生育因素、日常生活方式和环境因素与女性系统性硬皮病(systemic sclerosis,SSc)患病的关联。方法 2012年8月~2015年12月,收集来自于安徽医科大学附属医院的100例女性SSc患者和来自于合肥市社区的400例女性对照的相关信息,用单因素和多因素非条件Logistic回归分析影响SSc患病的因素。结果 单因素Logistic回归分析发现11个因素与SSc的患病有关。多因素Logistic回归分析显示,肥胖(OR=0.464,95% CI:0.229~0.939)为SSc的保护因素,而农民(OR=4.458,95% CI:2.379~8.352)、教师/会计/文员(OR=9.740,95% CI:3.153~30.909)、制鞋/服装/纺织工人(OR=16.150,95% CI:4.933~52.873)、偏瘦(OR=3.733,95% CI:1.440~9.636)、服用避孕药(OR=3.994,95% CI:1.291~12.361)、流产(OR=4.679,95% CI:2.365~9.258)、其他接触的人吸烟(OR=5.059,95%CI:2.582~9.913)、噪声暴露(OR=2.184,95% CI:1.018~4.685)、有机溶剂暴露(OR=4.432,95% CI:1.158~16.965)、药物过敏史(OR=3.564,95% CI:1.425~8.916)为SSc患病的危险因素。结论 多个环境因素与SSc的患病有关,应针对性加强SSc的预防和患者康复工作。
-
关键词:
- 硬皮病,系统性 /
- 危险因素 /
- Logistic模型
Abstract: Objective To explore the impact of menstrual and obstetrical factors, daily lifestyle and environmental factors on systemic sclerosis (SSc) among women. Methods 100 female SSc patients from affiliated hospitals of Anhui Medical University and 400 female controls from communities of Hefei city were recruited from August 2012 to December 2015.Univariate and multiple Logistic regression analyses were used to examine the associations of environmental factorswith SSc risk. Results There were 11 factors associated with SSc when univariate unconditional Logistic regression was used. Multiple Logistic aggression analysis revealed that obesity (OR=0.464, 95% CI:0.229-0.939) was protective factor for SSc, and farmers (OR=4.458, 95% CI:2.379-8.352), teachers/accountant/clerk (OR=9.740, 95% CI:3.153-30.909), cobbler/textile worker/garment worker(OR=16.150, 95% CI:4.933-52.873), thinner (OR=3.733,95% CI:1.440-9.636), taking birth control pills (OR=3.994,95% CI:1.291-12.361), abortion (OR=4.679,95% CI:2.365-9.258), other contact people smoking (OR=5.059,95% CI:2.582-9.913), noise exposure (OR=2.184,95% CI: 1.018-4.685), organic solvents exposure (OR=4.432,95% CI:1.158-16.965) and history of drug allergy (OR=3.564,95% CI:1.425-8.916) were risk factors for SSc.Conclusions Many environmental factors were related to SSc. Preventive measures for SSc and rehabilitation measures for patients should be reinforced.-
Key words:
- Systemic sclerosis /
- Risk factors /
- Logistic regression
-
左亭,蒋真,李向培,等. 系统性硬化症相关肺间质病变临床特征分析及随访观察 [J]. 中华疾病控制杂志, 2015,19(9): 918-921. Marder W, Somers EC. Is pregnancy a risk factor for rheumatic autoimmune diseases [J]. Curr Opin Rheumatol, 2014,26(3):321-328. Russo PA, Lester S, Roberts-Thomson PJ. Systemic sclerosis, birth order and Parity [J]. Int J Rheum Dis, 2014,17(5):557-561. Pisa FE, Bovenzi M, Romeo L, et al. Reproductive factors and the risk of scleroderma: an Italian case-control study [J]. Arthritis Rheum, 2002,46(2):451-456. Kettaneh A, Al Moufti O, Tiev KP, et al. Occupational exposure to solvents and gender-related risk of systemic sclerosis: a meta-analysis of case-control studies [J]. J Rheumatol, 2007,34(1):97-103. Masi AT. Preliminary criteria for the classification of systemic sclerosis (scleroderma) [J]. Arthritis & Rheumatology, 1980,23(5):581-590. Roberts-Thomson PJ, Jones M, Hakendorf P, et al. Scleroderma in South Australia: epidemiological observations of possible pathogenic significance [J]. Intern Med J, 2001,31(4):220-229. Gold LS, Ward MH, Dosemeci M,et al. Systemic autoimmune disease mortality and occupational exposures [J]. Arthritis Rheum, 2007,56(10):3189-3201. Bovenzi M, Barbone F, Pisa FE, et al. A case-control study of occupationalexposures and systemic sclerosis [J].Int Arch Occup Environ Health, 2004,77(1): 10-16. Marighela TF, Genaro Pde S, Pinheiro MM, et al. Risk factors for body composition abnormalities in systemic sclerosis [J]. Clin Rheumatol, 2013,32(7):1037-1044. Caporali R, Caccialanza R, Bonino C, et al. Disease-related malnutrition in outpatients with systemic sclerosis [J].Clin Nutr, 2012,31(5):666-671. Bharadwaj S, Tandon P, Gohel T, et al. Gastrointestinal Manifestations, Malnutrition, and Role of Enteral and Parenteral Nutrition in Patients With Scleroderma [J]. J Clin Gastroenterol, 2015,49(7):559-564. Beebe JL, Lacey JV,Mayes MD, et al. Reproductive history, oral contraceptive use, estrogen replacement therapy and the risk of developing scleroderma [J]. Arthritis Rheum, 1997,40:S100. 马丽,杨雪峰. 雌激素及其受体与原因不明复发性流产 [J]. 国际生殖健康/计划生育杂志, 2010,29(1):41-44. 葛会美,高美华. 吸烟和被动吸烟对青少年免疫系统的危害 [J]. 中国当代医药, 2015,22(25):142-144,147. Chaudhary P, Chen X, Assassi S, et al. Cigarette smoking is not a risk factor for systemic sclerosis [J]. Arthritis Rheum, 2011,63(10):3098-3102. Aryal BK, Khuder SA, Schaub EA. Meta-analysis of systemic sclerosis and exposure to solvents [J]. Am J Ind Med, 2001,40(3):271-274. Barragán-Martínez C, Speck-Hernández CA, Montoya-Ortiz G, et al. Organic solvents as risk factor for autoimmune diseases: a systematic review and meta-analysis [J]. PLoS One, 2012,7(12):e51506. Nagai Y, Yamanaka M, Nishimura S,et al. Drug eruption due to bosentan in a patient with systemic sclerosis [J]. Mod Rheumatol, 2006,16(3):188-190. Naniwa T, Maeda S, Sawada H, et al. Drug-induced hypersensitivity syndrome associated with a marked increase in anti-paramyxovirus antibody titers in a scleroderma patient [J]. Allergol Int, 2007,56(3):303-308.
点击查看大图
计量
- 文章访问数: 310
- HTML全文浏览量: 56
- PDF下载量: 34
- 被引次数: 0