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临床特点联合实验室指标对狼疮肾炎病理分型的预测研究

王芬 徐建华 蔡静玉 汤华阳 吴永贵 卢文

王芬, 徐建华, 蔡静玉, 汤华阳, 吴永贵, 卢文. 临床特点联合实验室指标对狼疮肾炎病理分型的预测研究[J]. 中华疾病控制杂志, 2016, 20(7): 725-728,733. doi: 10.16462/j.cnki.zhjbkz.2016.07.020
引用本文: 王芬, 徐建华, 蔡静玉, 汤华阳, 吴永贵, 卢文. 临床特点联合实验室指标对狼疮肾炎病理分型的预测研究[J]. 中华疾病控制杂志, 2016, 20(7): 725-728,733. doi: 10.16462/j.cnki.zhjbkz.2016.07.020
WANG Fen, XU Jian-hua, CAI Jing-yu, TANG Hua-yang, WU Yong-gui, LU Wen. Clinical and laboratory predictors of pathological classification of lupus nephritis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2016, 20(7): 725-728,733. doi: 10.16462/j.cnki.zhjbkz.2016.07.020
Citation: WANG Fen, XU Jian-hua, CAI Jing-yu, TANG Hua-yang, WU Yong-gui, LU Wen. Clinical and laboratory predictors of pathological classification of lupus nephritis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2016, 20(7): 725-728,733. doi: 10.16462/j.cnki.zhjbkz.2016.07.020

临床特点联合实验室指标对狼疮肾炎病理分型的预测研究

doi: 10.16462/j.cnki.zhjbkz.2016.07.020
基金项目: 

国家自然科学基金(81371722)

详细信息
    作者简介:

    王芬(1964-),女,广西北海人,副主任医师,学士。主要研究方向:风湿免疫病,系统性红斑狼疮。

  • 中图分类号: R593.241

Clinical and laboratory predictors of pathological classification of lupus nephritis

  • 摘要: 目的 通过临床及实验室指标,建立狼疮肾病理分型的预测模式。方法 2011-2015年我院住院有肾病理的系统性红斑狼疮 (systemic lupus erythematosus,SLE)患者,经糖皮质激素等治疗2月以上,尿蛋白仍阳性的患者201例,分析其临床及实验室指标,采用Epi Data 3.1 和SPSS 21.0软件进行统计。结果 Ⅱ型17例,Ⅲ型26例,Ⅳ型135例,Ⅴ型23例;单因素分析:增殖型年龄及发病年龄均小、SLEDAI高、贫血多、C3低、C1q(64.0%)及ds-DNA阳性率均高(53.4%);膜型发病年龄大,ds-DNA阳性率低(13.0%);系膜型卧位后尿蛋白转阴性率为67.4%。Logistic回归分析显示,相对于其它类型,系膜型SLEDAI低,卧位后尿蛋白转阴性率高;增殖型SLEDAI高、尿蛋白阳性率及抗 ds-DNA 阳性率均高;膜型发病年龄大、抗 ds-DNA阳性率低。结论 狼疮肾病理分型的预测模式:SLEDAI低,卧位后尿蛋白转阴性率高是Ⅱ型的强预测指标;SLEDAI高、尿蛋白阳性、抗 ds-DNA 阳性,是Ⅲ/Ⅳ型的预测指标;发病年龄大、抗 ds-DNA阳性率低是Ⅴ型的预测指标。
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出版历程
  • 收稿日期:  2016-01-11
  • 修回日期:  2016-04-27

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