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2015年深圳地区疱疹性咽峡炎的病原学与流行病学特征分析

王玉洁 杨洪 姚相杰 张海龙 陈龙 何雅青

王玉洁, 杨洪, 姚相杰, 张海龙, 陈龙, 何雅青. 2015年深圳地区疱疹性咽峡炎的病原学与流行病学特征分析[J]. 中华疾病控制杂志, 2016, 20(8): 759-763. doi: 10.16462/j.cnki.zhjbkz.2016.08.002
引用本文: 王玉洁, 杨洪, 姚相杰, 张海龙, 陈龙, 何雅青. 2015年深圳地区疱疹性咽峡炎的病原学与流行病学特征分析[J]. 中华疾病控制杂志, 2016, 20(8): 759-763. doi: 10.16462/j.cnki.zhjbkz.2016.08.002
WANG Yu-jie, YANG Hong, YAO Xiang-jie, ZHANG Hai-long, CHEN Long, HE Ya-qing. The etiological and epidemiological characteristics of herpangina cases in Shenzhen City, 2015[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2016, 20(8): 759-763. doi: 10.16462/j.cnki.zhjbkz.2016.08.002
Citation: WANG Yu-jie, YANG Hong, YAO Xiang-jie, ZHANG Hai-long, CHEN Long, HE Ya-qing. The etiological and epidemiological characteristics of herpangina cases in Shenzhen City, 2015[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2016, 20(8): 759-763. doi: 10.16462/j.cnki.zhjbkz.2016.08.002

2015年深圳地区疱疹性咽峡炎的病原学与流行病学特征分析

doi: 10.16462/j.cnki.zhjbkz.2016.08.002
基金项目: 

国家自然科学基金(81371815)

详细信息
    作者简介:

    王玉洁(1989-),女,河南新乡人,在读硕士研究生。主要研究方向:肠道病毒。

  • 中图分类号: R512.51;R512.92;R181

The etiological and epidemiological characteristics of herpangina cases in Shenzhen City, 2015

  • 摘要: 目的 分析2015年监测的深圳地区疱疹性咽峡炎的病原学情况和流行病学特征,为疱疹性咽峡炎的预防和控制提供数据基础。方法 2015年共收集深圳地区70例疱疹性咽峡炎病例粪标本,采用荧光定量RT-PCR(real time PCR,RT-PCR)和RT-snPCR(real time transcription-seminested PCR,RT-snPCR)法对样本进行肠道病毒(enterovirus,EV)检测,并对主要的流行株进行基因亚型的鉴别和系统进化分析。结果 在70例疱疹性咽峡炎患者中,EV阳性率为88.57%;阳性结果中共检测出6种病毒,其中,柯萨奇病毒A6(coxsackie virus A6,CA6)和柯萨奇病毒A2(coxsackie virus A2,CA2)的阳性标本最多,分别为22例和16例,且分别占总发病病例数的31.43%和22.86%;基于核酸序列的VP1区构建的系统进化树显示,CA6毒株的基因亚型均为B型,核苷酸和氨基酸同源性分别为96.2%~100%和97.3%~100%。CA2与香港地区CA2流行株的序列高度同源,其核苷酸同源性为91.1%~99.6%,氨基酸同源性为92.4%~100%。结论 2015年深圳地区流行的病原均属于A组肠道病毒,其中B型CA6 是引起疱疹性咽峡炎的主要流行病毒株。
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出版历程
  • 收稿日期:  2016-04-22
  • 修回日期:  2016-06-07

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