Abstract: Objective To explore the association between environmental risk factors and childhood acute lymphoblastic leukemia (ALL). Methods Children with ALL from Tianjin Blood Disease Hospital in 2015 were enrolled in this case-control study. Controls were randomly selected from health children during the same period. Information was collected by one-on-one questionnaire. Chi-square test and non-conditional Logistic regression model were used to analyze the association between environmental risk factors and ALL. The adjusted population attributable risk percent (PARP) for the related risk factors were calculated. Results Single factor analysis showed that children with history of contacting with the paints and coatings(χ²=7.146,P=0.008), eat less vegetables and fruits(χ²=47.070,P<0.001) and exposure to home decoration(χ²=9.030,P=0.003) in case group were more than those in control group. Results from multivariate analysis also showed these three factors were significantly associated with ALL, with odds ratios of 2.174(1.031-4.583), 4.990(3.017-8.253) and 2.831(1.361-5.889) respectively, and the PARP of the three factors were 11.2%, 25.2% and 11.7% respectively. Conclusions Contacting with the paints and coatings, partiality for a particular kind of food and exposure to home decoration could be risk factors for childhood ALL.