Abstract: Objective To explore the Hepatitis B epidemic characteristics and distribution in the import and export cases of Tianjin and to provide basis for the regional integration. Method Hepatitis B cases data were derived respectively from "China information system for disease control and prevention" among 2005-2015 by current address and reported regions Tianjin. Then studies of gender, age, reported region, occupation and reporting agency were performed according to the category of imported or exported cases. Results The rate of export and import cases respectively was 14.96% (6 311/42 190) and 3.28%(1 218/37 097) (χ²=3 130.935, P<0.001). Hebei Province got both the first import and export rate (57.47%, 57.96%), among which males (63.79-75.93%), aged 20-49 and farmers were the major population. The export number and constituent ratio of children, students aged 0-19 was larger than those imported. Conclusions Hepatitis B cases addressed in Tianjin are mainly reported by local hospitals. The export or import cases are closely related with Hebei and Beijing, which regional integration should be strengthened for Hepatitis B management and control.