Abstract: Objective To investigate the health-related quality of life and examine its associated factors among older adults living in Wuhan. Methods A across-sectional study was conducted among 1 272 participants and EuroQol Five Dimensions Questionnaire (EQ-5D) was used to evaluate quality of life and questionnaire investigation. Multivariate linear stepwise regression was employed to analyze the associated factors with the health-related quality of life. Results Older adults had good quality of life living in Wuhan community-dwelling. Mean scores of the EQ-5D index and the visual analogue scale (VAS) were (0.79±0.25) and (60.76±23.53) respectively. Proportion of older adults reporting a good mobility, self-care, usual activities, pain/discomfort and anxiety/depression were 86.00%, 91.03%, 87.18%, 75.53%, and 90.17% respectively. Multivariate regression analysis showed that having chronic diseases, doing physical exercise, and the number of persons contacted per day were associated with the quality of life, β' was -0.068 3(chronic diseases), 0.056 6(training 3-4 times a week), 0.078 2(training 5-7 times a week),0.106 5(contacting 10-19 people every day),0.099 7(contacting 20 people every day). In addition, having specific chronic diseases, such as hypertension (-0.085 5), diabetes (-0.137 2), ischemic heart disease (-0.144 6), gastroenteritis (-0.065 7) were associated with their quality of life(all P<0.05). Conclusions Having chronic diseases, the lack of exercise, and small social networks were associated with lower score of health-related quality of life among older adults in China.