Abstract: Objective To analyze the epidemic trend and characteristics of syphilis in Fuzhou from 2011 to 2015, and put forward the corresponding countermeasures for prevention and control. Methods Descriptive epidemiological methods were used to analyze the syphilis epidemic situation from 2011 to 2015. Results The average annual incidence of syphilis was 13.17/100 000, and the incidence of syphilis showed an upward trend (χ_trend²=182.340, P<0.001), and the average annual growth rate was 22.50% during the 5 years. The incidences of latent syphilis (χ_trend²=199.544, P<0.001) and primary syphilis (χ_trend²=13.727, P<0.001) showed upward trend. The high incidence of syphilis areas included Guangchang County, Nanfeng County, Nancheng County, Le'an County, Linchuan District and Lichuan County. The infectious people were mainly farmers, householders and the unemployed, and the proportion of farmers showed downward trend (χ_trend²=8.191, P=0.004), while the proportion of householders and the unemployed showed an upward trend (χ_trend²=25.464, P<0.001). There were significant differences in the incidence of latent syphilis, primary syphilis, secondary syphilis and congenital syphilis in different sex groups (all P<0.05). The age of onset was mainly in the range of 20-49 years old, and the age distribution of different sexes was different. Conclusions Administrators need to take effective interventions for syphilis among high incidence areas, with farmers, householders and the unemployed fixed on, and strengthen sexual health education, and should make early detection, early diagnosis and early standardized treatment of latent syphilis and primary syphilis in Fuzhou City.