Abstract: Objective To understand the epidemiological characteristics of HIV/AIDS who joined the highly active antiretroviral therapy in Shandong Province from 2008 to 2015. Methods The basic information of HIV/AIDS who joined the antiviral treatment in Shandong Province from 2008 to 2015 were collected, and the database was established by Excel 2010. Data were analyzed using SPSS 23.0. Results Of the 5 330 cases, 86.1% were male and 42.8% were married,the average age was 34.8±10.6 years old. The proportion of the HIV/AIDS patients that were being male, unmarried, under 35 years older showed a trend of increase. 93.6% of them were infected through sexual contacts, and the homosexual transmission increased during 2008-2015. 80.7% were in clinical phase I. The average baseline CD4⁺T lymphocyte count was 272.4(139.0,370.0). 86.1% of them were without any symptoms when joined treatment. Median of the interval between HIV confirmation and HAART initiation was 3 months. Proportion of the HIV/AIDS patients that were WHO Ⅰ, with higher baseline CD4⁺T lymphocyte count, without any symptoms showed a trend of increase from 2008 to 2015. Conclusions In Shandong province, the timing of HIV/AIDS receiving antiretroviral therapy was earlier than before, the detection and treatment on HIV should be earlier.