Abstract: Objective To investigate the prevalence of fatty liver in primary examination members of Qidong hepatoma family in Jiangsu and analyze its associated factors in order to provide scientific basis for the prevention and treatment of fatty liver in members of hepatoma family. Methods A total of 537 participants in early detection of liver cancer family were selected from Qidong People's Hospital from January 2014 to December 2015 and their medical records and basic personal information were collected to analyze the prevalence of fatty liver. The related factors of fatty liver were explored by univariate analysis and Logistic regression analysis. Results Among the 537 participants, 112 cases of fatty liver were diagnosed by B-ultrasonography and the prevalence rates of fatty liver was 20.86%, which was higher in males than that in females. (22.75%>19.15%,(口恶)²=5.292, P=0.021). The prevalence of fatty liver was increased with age, which was higher in alcoholic drinks, overweight and obese, hypertension and hyperglycemia people, and the differences were statistically significant (all P<0.05). Moreover, multivariate Logistic regression analysis showed that overweight and obesity, hypertension, tobacco and alcohol addiction, hyperglycemia were risk factors of fatty liver disease. Conclusions We need to strengthen the lifestyle intervention, have no smoking and limited amount of liquor, keep weight, blood pressure and blood sugar in normal levels in order to reduce the incidence of fatty liver.