IL-17、TLR4、P2X7基因多态与慢性阻塞性肺疾病的关联研究

张之海; 戴垚垚; 陈杰; 徐丽娜; 尚云飞; 陆荣荣; 王建明

doi:10.16462/j.cnki.zhjbkz.2018.02.010

IL-17、TLR4、P2X7基因多态与慢性阻塞性肺疾病的关联研究

doi: 10.16462/j.cnki.zhjbkz.2018.02.010

1. 南通市疾病预防控制中心开发区站, 江苏南通 226007;
2. 南通市第三人民医院呼吸科, 江苏南通 226000;
3. 南京医科大学公共卫生学院流行病学系, 江苏南京 211166

基金项目:

南通市社会事业科技创新与示范计划项目（HS2014057）；江苏省社会发展项目（SBE2016740780）

详细信息

作者简介:
张之海(1980-),男,江苏南通人,主管医师,学士。主要研究方向:预防医学。

中图分类号: R563.9
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出版历程
- 收稿日期: 2017-05-15
- 修回日期: 2017-09-25

Genetic polymorphisms of IL-17, TLR4 and P2X7 in association with the risk of chronic obstructive pulmonary disease

1. Development Zone Branch, Nantong Center for Disease Control and Prevention, Nantong 226007, China;
2. Department of Respiratory Medicine, the Third People's Hospital of Nantong, Nantong 226000, China;
3. Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China

摘要

摘要: 目的探讨炎症相关基因白细胞介素17（interleukin-17，IL-17）、Toll样受体4（toll-like receptors 4，TLR4）、嘌呤受体（purinergic receptor P2X 7，P2X7）遗传多态与慢性阻塞性肺疾病（chronic obstructive pulmonary disease，COPD）易感性的关系。方法采用病例对照研究设计，病例组为2015年6月~2016年5月南通市第三人民医院收集的COPD确诊患者，共152例。对照组来自参加健康体检的居民，按年龄和性别与病例进行频数匹配，共201例。基因分型采用TaqMan分型技术，关联强度采用OR值及95%CI值表示。结果采用Bonferroni校正后，IL-17基因rs2275913、rs763780；TLR4基因rs10759932、rs2737190；P2X7基因rs1718119遗传多态与COPD的易感性关联均有统计学意义（均有P<0.05）。rs2275913A等位基因（OR=0.62，95%CI：0.46~0.86，P=0.003）；rs763780C等位基因（OR=1.96，95%CI：1.29~2.98，P=0.001）；rs10759932C等位基因（OR=0.49，95%CI：0.34~0.73，P<0.001）；rs2737190G等位基因（OR=0.51，95%CI：0.37~0.71，P<0.001）。结论 IL-17、TLR4、P2X7基因多态影响COPD遗传易感性。
- 肺疾病,慢性阻塞性 /
- 白细胞介素17 /
- Toll样受体4 /
- 受体,嘌呤能P2 /
- 基因
Abstract: Objective To explore the genetic polymorphisms of interleukin-17 (IL-17), toll-like receptors 4 (TLR4) and purnergic receptor P2X7 (P2X7) in association with the chronic obstructive pulmonary disease (COPD). Methods A case-control study was performed by recruiting 152 COPD cases from the Third People's Hospital of Nantong from June 2015 to May 2016. Healthy controls were selected from a group of people attending the physical examination and were frequency-matched to the cases by sex and age. Genotyping was performed by using the TaqMan allelic discrimination technology. The association was estimated by using odds ratio (OR) and 95% confidence interval (CI). Results After the Bonferroni correction, the polymorphisms of rs2275913 and rs763780 in IL-17 gene, rs10759932 and rs2737190 in TLR4 gene, and rs1718119 in P2X7 gene were significantly associated with the altered risks of COPD (all P<0.05). Individuals carrying rs2275913 allele A had a reduced risk of COPD, with the OR of 0.62(95% CI:0.46-0.86). Individuals carrying rs763780 allele C had an increased risk, with the OR of 1.96(95% CI:1.29-2.98). Individuals carrying rs10759932 allele C had a reduced risk, with the OR of 0.49(95% CI:0.34-0.73). Individuals carrying rs2737190 allele G had a reduced risk, with the OR of 0.51(95% CI:0.37-0.71). Conclusions Genetic polymorphisms of IL-17, TLR4 and P2X7 were significantly associated with the altered risks of COPD.
- Pulmonary disease, chronic obstructive /
- IL-17 /
- TLR4 /
- P2X7 /
- Gene