Abstract: Objective To analyze the fluctuations and main influencing factors of hospitalization expenditures of patients with alveolar echinococcosis(AE), and to provide reference for comprehensive treatment of alveolar echinococcosis. Methods Based on the hospital information system of two 3A grade hospitals in Qinghai Province from 2004 April to 2016 January, multiwarite Logistic analysis was used to analyze the influencing factors of hospitalization expenditures. Results The total 300 cases of AE patients, including 132 cases of male (44.0%), and 168 cases were female (56.0%); the average age was(38.87±13.62)years old; Tibetan 225 cases (75.0%);the median hospitalization days were 15 (1-102) days, the median total hospitalization expenses of 14 115.25 (361.20-187 670.60) yuan.The medicine costs accounted for 36.0%, the diagnosis costs accounted for 20.0%, supplies costs accounted for 19.0% and the cost of treatment accounted for 13.0%. The binary Logistic regression analysis showed that hospitalization days, surgery or not, payment terms and combined disease were the main factors affecting hospitalization expenses and the difference was statistically significant (all P<0.05). Conclusions In recent years, the cost of hospitalization of alveolar echinococcosis increased day by day. Having other diagnoses, treatment methods and payment terms are influencing factors of hospitalization expenditures, so the choice of appropriate treatment, the development of reasonable single disease management measures to control hospitalization expenses.