Abstract: Objective To investigate the dynamic pattern of injury during 1991-2014 in Jiading District, Shanghai, and to analyze the characteristic of major injury causes that influence men and women in different age groups. Methods The injury death cases from the death registry system were used in our study. Percent change and average annual percent change were used to analyze the temporal trend of injury death. The constituent ratios and age-standardized mortalities were calculated to assess the relative importance, age distribution and gender disparity.Results From 1991 to 2014, a total of 6 722 people died of injuries in Jiading District. The corresponding constituent ratio and age-standardized mortality were 7.26% and 36.37/100 000, respectively. The age-standardized mortality of men was higher than women and people aged 15 to 35 years were most affected by injury. Transport accidents and suicide were the major causes influencing people aged 15 to 35 years.Conclusion The mortality of injury declined during the study period. It's still urgent and important to strengthen the prevention of transport accidents in men aged 15 to 35 years, suicide in women aged 15 to 35 years and accidental falls in people aged more than 65 years.