Abstract: Objective To explore the influence of interaction of SLC2A9 gene rs1014290 and rs7442295 and body mass index (BMI) on hyperuricemia in Ningxia so as to provide evidences for the etiology of hyperuricemia. Methods 366 subjects identified by regular physical examination in a certain medical institution were selected as case group,meanwhile, 366 subjects were selected as control group by 1:1 pairing according to gender, ethnicity and age. The crossover analysis was used to analyze the interaction relationship between genetic polymorphisms of rs1014290, rs7442295 and BMI in hyperuricemia population. Results The difference of creatinine, total cholesterol, triglyceride, BMI and systolic blood pressure between case group and control group were statistically significant (P<0.05), and the case group was slightly higher than the control. The genotypes of rs1014290 were statistically significant (χ²=13.117, P=0.004). The genotypes of different genetic models at rs1014290 were statistically significant (χ²=11.225, P=0.001). The morbidity of hyperuricemia in GG genotype was 47.4% of the cases with hyperuricemia in GA + AA genotype. In the crossover analysis of rs1014290 and BMI, the additive model had statistical significance (U=4.874, P=0.032), S=-2.022, AP=0.674, AP*=1.495, RERI=1.227. There was statistical significance based on the multiplicative model (P=0.017),ORint=4.123. Conclusion There is an additive interaction and multiplicative interaction between rs1014290 and BMI.