摘要:
目的 本研究旨在探讨钢铁工人加权倒班指数（weighted shift index，WSI）与高尿酸血症（hyperuricemia，HUA）之间的剂量反应关系。方法 共有7 617例钢铁工人纳入本次研究。通过问卷调查和体格检查收集相关信息，应用限制性立方样条模型（restricted cubic spline，RCS）分析WSI与HUA之间的关系，并结合多因素Logistic回归模型分析其影响因素。结果 研究人群中HUA的患病率为36.2%（男性37.5%，女性20.9%），在调整了年龄、性别、吸烟、饮酒、饮食、体力活动、睡眠时间、睡眠质量、人均家庭月收入、受教育水平、健康状况之后，RCS模型分析结果显示钢铁工人WSI与HUA之间存在非线性的剂量反应关系（整体关联性检验χ2=30.51，P<0.001；非线性检验χ2=29.71，P<0.001）。结论 WSI与钢铁工人HUA之间存在非线性的剂量反应关系。
Abstract:
Objective To explore the dose-response relationship between weighted shift index (WSI) and hyperuricemia (HUA) in steel workers. Methods A total of 7 617 steel workers were interviewed with a standardized questionnaire and physically examined. We analyzed the cross-sectional relationship between WSI and HUA by restrictive cubic spline (RCS) model, and the potential confounders by multi-factor Logistic regression model. Results Among participants, 36.2% of the individuals had hyperuricemia (37.5% in males and 20.9% in females). After adjusting for age, gender, smoking, drinking, diet, physical activity, sleep duration, sleep quality, monthly family income per capita, education, and health status, RCS model illustrated a nonlinear dose-response relationship between WSI and HUA in steel workers (χ2=30.51, P<0.001 for overall association test and χ2=29.71, P<0.001 for nonlinear test). Conclusions There is a nonlinear dose-response relationship between WSI and HUA in steel workers.
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