Abstract: Objective To investigate rehabilitation effect of hand training on language function of patients with aphasia. Methods A total of 40 patients with aphasia were randomly divided into control group (n=20) and experimental group (n=20). Both groups received routine drug treatment and rehabilitation, and the experimental group was given additional hand training for 6 weeks. Aphasia battery of Chinese (ABC) was used to evaluate the patients' language function before and after 6 weeks of training respectively. Results The ABC scores of the two groups were significantly improved after 6 weeks (t_con=-10.184, P<0.001;t_exp=-13.158, P<0.001). There was no statistically significant difference between the two groups before hand training (t=-0.725, P=0.473). After 6 weeks of hand training, the ABC score of the experimental group was significantly higher than that of the control group (t=4.425, P<0.001). There was no significant difference in the ABC scores between the two groups of sensory aphasia (t=-0.171, P=0.872). The ABC scores of patients with motor and mixed aphasia in experimental group were significantly higher than those in the control group (t=5.187, P<0.001; t=4.108, P=0.003). Conclusion Hand training can effectively improve the language function of patients with aphasia.