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摘要: 本文针对流行病学研究中多中心干预设计、效应异质性、应答率、失访率等问题,深入分析了其与样本代表性的关系。同时,针对当前精准医学和基于大数据流行病学研究的发展趋势,讨论了样本代表性问题的现实意义。总而言之,人群健康研究工作者应正确认识样本代表性在流行病学研究中的作用和地位,科学合理设计研究以获得最佳证据。Abstract: The review clarifies the relation of representativeness to multicenter intervention design, heterogeneity, response rate, and loss to follow-up. In addition, the implications of representativeness in the era of precision medicine and big data-based epidemiological studies are further discussed. In summary, population health researchers should have a fair understanding of the function and role of representativeness in epidemiology in order to conduct scientifically plausible studies to generate the best evidence for practice.
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Key words:
- Epidemiology /
- Sample /
- Representativeness
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