重庆市男性大学生昼夜节律紊乱与抑郁症状的关联研究

侯贵钟; 刘坤; 张爱华; 陈卿; 曹佳

doi:10.16462/j.cnki.zhjbkz.2020.04.007

重庆市男性大学生昼夜节律紊乱与抑郁症状的关联研究

doi: 10.16462/j.cnki.zhjbkz.2020.04.007

侯贵钟¹,
刘坤²,
张爱华¹,
陈卿^2, ,,
曹佳^{1, 2, ,}

1.
550025 贵州, 贵州医科大学公共卫生学院毒理学教研室
2.
400038 重庆, 陆军军医大学(第三军医大学)军事预防医学系毒理学研究所

基金项目: 国家重点研发计划课题(2017YFC1002001);国家自然科学基金(81871208)

详细信息

通讯作者:
曹佳, E-mail:caojia1962@126.com

陈卿, E-mail:chenqingforward@gmail.com

中图分类号: R749.4
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出版历程
- 收稿日期: 2019-12-20
- 修回日期: 2020-02-01
- 刊出日期: 2020-04-10

Correlation between circadian disruption and depressive symptom in male undergraduates in Chongqing

HOU Gui-zhong¹,
LIU Kun²,
ZHANG Ai-hua¹,
CHEN Qing^{2
, ,},
CAO Jia^{1, 2
, ,}

1.
Department of Toxicology, School of Public Health, Guizhou Medical University, Guiyang 550025, China
2.
Institute of Toxicology, College of Military Preventive Medicine, Army Military Medical University(Third Military Medical University), Chongqing 400038, China

Funds: National Key R & D Program of China(2017YFC1002001); National Natural Science Foundation of China(81871208)

More Information

Corresponding author: CHEN Qing, E-mail:chenqingforward@gmail.com; CAO Jia, E-mail:caojia1962@126.com

摘要

摘要: 目的分析重庆市青年男性人群中昼夜节律紊乱是否与抑郁症状存在关联。方法采用中文版慕尼黑睡眠时型问卷(Munich chronotype questionnaire, MCTQ)测量社会性时差(用来反映昼夜节律紊乱的指标), 同时测量了平均睡眠时长和反映生物钟特性的睡眠时型指标。采用抑郁自评量表(self-rating depression scale, SDS)的标准分测量抑郁症状。结果研究对象的社会性时差为0.9(0.5, 1.3)h, 其与睡眠时型指标之间呈现较强的相关性(r=0.73, P < 0.001)。社会性时差与SDS标准分呈正相关, 校正睡眠时型、睡眠时长、年龄、体重指数、体育运动、吸烟、饮酒、饮茶等因素后, 社会性时差每增加0.5h, SDS标准分相应增加2.1%(95% CI:0.5%~3.5%, P=0.011)。结论社会性时差与SDS标准分呈正相关, 提示昼夜节律紊乱可能与抑郁症状有关。
- 生物钟 /
- 睡眠 /
- 慕尼黑睡眠时型问卷 /
- 抑郁
Abstract: Objective To analyze the association between circadian disruption and depressive symptoms in Chongqing young males. Methods Among 587 male college students in Chongqing, the Chinese version of the Munich chronotype questionnaire(MCTQ) was used to measure social jetlag(an indicator of circadian disruption), mean sleep duration and chronotype, which reflected individual biological clock. Depression symptom was measured using standard score of the Self-rating Depression Scale(SDS). Results The subjects' social jetlag was 0.9(0.5 to 1.3) h. There was a strong correlation between social jetlag and chronotype indicator(correlation coefficient = 0.58, P < 0.001).The social jetlag was positively correlated with the SDS standard score. For every 0.5 hour increase in the social jetlag, the SDS standard score increased by 2.1%(95%CI: 0.5%-3.5%, P= 0.011). Conclusion There is a correlation between social jetlag and SDS standard score, suggesting that circadian disruption may be related to depressive symptom.
- Circadian clock /
- Sleep /
- Munich chronotype questionnaire /
- Depression

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图 1 MCTQ各指标间相互关系及社会性时差与SDS标准的关系分析

注:A-C分别表示MSFSc与社会性时差、MSFSc与平均睡眠时长、社会性时差与平均睡眠时长的关系(相关分析); D表示社会性时差和SDS标准分的关系(多重线性回归)。

Figure 1. Relationship between MCTQ indicators and relationship between social jetlag and SDS standard score

下载: 全尺寸图片幻灯片

表 1 研究对象的特征分布

Table 1. Characteristic distribution of the study subjects

变量	频数	数据分布(%)
年龄(岁)	587	20.0(20.0, 21.0)^a
体重指数(kg/m²)	587	21.0(19.6, 22.9)^a
< 18.5	62	10.6
18.5~	437	74.4
24.0~	71	12.1
≥28.0	17	2.9
吸烟行为
从不吸烟	460	78.4
曾经吸烟, 现已戒烟	19	3.3
吸烟	107	18.3
饮酒行为
从不饮酒	294	50.5
曾经饮酒, 现已戒酒	7	1.2
饮酒	284	48.3
饮茶行为
从不饮茶	364	62.0
曾经饮茶	102	17.5
饮茶	120	20.5
体育运动
不参加	99	16.9
参加	488	83.1
平均睡眠时长(h/d)	535	7.1(6.7, 7.6)^a
≤6.5	93	6.2(6.0, 6.3)^a
6.5~	128	6.8(6.7, 6.9)^a
7.0~	145	7.3(7.1, 7.4)^a
7.5~	115	7.8(7.6, 7.9)^a
8.0~	30	8.2(8.1, 8.3)^a
8.5~	15	8.6(8.6, 8.6)^a
> 9.0	9	9.2(9.1, 9.4)^a
MS_FSc分类(睡眠时型)	414	4.9(4.4, 5.5)^a
早起型(上1/3)	136	4.2(4.0, 4.4)^a
中间型(中1/3)	146	4.9(4.7, 5.1)^a
晚起型(下1/3)	132	5.8(5.6, 6.2)^a
社会性时差(h)	556	0.9(0.5, 1.3)^a
≤0.5	200	0.3(0.0, 0.4)^a
0.5~	177	0.8(0.7, 1.0)^a
1.0~	112	1.3(1.2, 1.4)^a
1.5~	58	1.8(1.7, 1.9)^a
> 2.0	39	2.3(2.2, 2.6)^a
SDS标准分	587	38(32, 45)^a
注:^aM(P₂₅, P₇₅)。

下载: 导出CSV

表 2 MCTQ各指标与SDS标准分的关联分析(单因素)

Table 2. Association of MCTQ indicators and SDS standard score (univariate analysis)

睡眠指标	样本量	SDS标准分^a	P值
睡眠指标	样本量	SDS标准分^a	Kruskal-Wallis法	Jonckheere-Terpstra法
社会性时差分类(h)			0.002	0.02
≤0.5	200	35(31, 42)
0.5~	177	40(33, 46)
1.0~	112	38(32, 45)
1.5~	58	38(32, 46)
> 2.0	39	41(35, 46)
平均睡眠时长分类(h/d)			0.262	0.600
≤6.5	93	38(33, 47)
6.5~	128	37(32, 43)
7.0~	145	38(32, 43)
7.5~	115	36(31, 42)
8.0~	30	39(32, 50)
8.5~	15	37(32, 52)
> 9.0	9	42(32, 52)
MS_FSc分类(睡眠时型)			0.142	0.126
早起型	136	36(32, 43)
中间型	146	37(32, 43)
晚起型	132	39(32, 46)
注:^aM(P₂₅, P₇₅)。

下载: 导出CSV

参考文献(23)

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重庆市男性大学生昼夜节律紊乱与抑郁症状的关联研究

doi: 10.16462/j.cnki.zhjbkz.2020.04.007

通讯作者:
曹佳, E-mail:caojia1962@126.com

陈卿, E-mail:chenqingforward@gmail.com

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Correlation between circadian disruption and depressive symptom in male undergraduates in Chongqing

Corresponding author: CHEN Qing, E-mail:chenqingforward@gmail.com; CAO Jia, E-mail:caojia1962@126.com

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重庆市男性大学生昼夜节律紊乱与抑郁症状的关联研究

doi: 10.16462/j.cnki.zhjbkz.2020.04.007

通讯作者: 曹佳, E-mail:caojia1962@126.com 陈卿, E-mail:chenqingforward@gmail.com

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出版历程

Correlation between circadian disruption and depressive symptom in male undergraduates in Chongqing

Corresponding author: CHEN Qing, E-mail:chenqingforward@gmail.com; CAO Jia, E-mail:caojia1962@126.com

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出版历程

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通讯作者:
曹佳, E-mail:caojia1962@126.com

陈卿, E-mail:chenqingforward@gmail.com