大数据生态流行病学理论模型

薛付忠

doi:10.16462/j.cnki.zhjbkz.2022.10.003

大数据生态流行病学理论模型

doi: 10.16462/j.cnki.zhjbkz.2022.10.003

薛付忠^{1, 2, ,}

1.
250012 济南, 山东大学齐鲁医学院公共卫生学院生物统计学系
2.
250003 济南, 国家健康医疗大数据研究院

基金项目:

国家重点研发计划 2020YFC2003500

详细信息

通讯作者:
薛付忠, E-mail: xuefzh@sdu.edu.cn

中图分类号: R181.2
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- 被引次数: 0
出版历程
- 收稿日期: 2022-07-22
- 修回日期: 2022-09-02
- 刊出日期: 2022-10-10

The theoretical model of big data eco-epidemiology

XUE Fu-zhong^{1, 2
, ,}

1.
Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China
2.
National Institute of Health Data Science of China, Jinan 250003, China

Funds:

National Key Research and Development Program of China 2020YFC2003500

More Information

Corresponding author: XUE Fu-zhong, E-mail: xuefzh@sdu.edu.cn

摘要

摘要: 当今大数据、人工智能时代背景下，生态流行病学既进入快速发展和应用阶段，又在理论范式、设计策略和统计方法等方面，面临诸多发展瓶颈；必须提出适于数字化智能时代的生态流行病学新理论范式、新设计策略和新统计方法。为此，本文创建了既相对独立又相互依赖的“现实世界”与“虚拟世界”中众多镶嵌层级内健康决定因素交互博弈的大数据生态流行病学模型；创立了现实和虚拟两个世界中，均以表观遗传为中介在现实世界、虚拟世界的健康决定因素、以基因组为核心的多组学因素间交互博弈的生态流行病学新病因模型；并在同一数字健康模型下，通过“同一健康”和“数字健康”两个赋能关键，“个体-种群-生态系统”一体化的三个视角，“公民参与、教育、环境、人类-动物健康保健和数字健康”五个维度之间的交互博弈，实现了生态流行病学范式的数字化转型；而数字技术是这一数字化转型的催化剂和始作俑者。这种生态流行病学新理论范式及其新设计与分析策略的系统科学方法（系统动力学模型、网络分析及网络动力学模型、多智能体系统模型以及超网络因果推断模型），共同构成了大数据生态流行病学的理论方法体系。
- 大数据 /
- 生态流行病学范式 /
- 数字化转型 /
- 系统科学 /
- 理论方法体系
Abstract: Under the background of today's big data and artificial intelligence era, eco-epidemiology has entered a stage of rapid development and application, but also faces many bottlenecks in the development of theoretical paradigms, design strategies and statistical methods. It is necessary to put forward new theoretical paradigms, new design strategies and new statistical methods of eco-epidemiology that suitable for the era of digital intelligence. To this end, this paper creates a big data eco-epidemiology model of the interactive game of health determinants in many mosaic levels in the "real world" and "virtual world" that are both relatively independent and interdependent; a new etiological model of eco-epidemiology in which the genome-centric multi-omics factors, the health determinants of the real world and the virtual world interact with epigenetics as an intermediary; and under the same digital health model, digital transformation of the eco-epidemiology paradigm could be realized using two enabling keys consisted of the "one health" and "digital health", the three perspectives of the integration of "individual-population-ecosystem", and the interactive game among the five dimensions of "citizen participation, education, environment, human-animal health care and digital health", in which digital technology is the catalyst and initiator of this digital transformation. This new theoretical paradigm of eco-epidemiology and its new systematic scientific methods for design and analysis (system dynamics model, network analysis and network dynamics model, multi-agent system model, and causal inference hypergraph model) together constitute the theoretical and methodological system of big data eco-epidemiology.
- Big data /
- Eco-epidemiology paradigm /
- Digital transformation /
- Systems science /
- Theoretical method system

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图 1 大数据生态流行病学理论范式

Figure 1. The theoretical paradigm of big data eco-epidemiology

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参考文献(30)

[1]	Susser M, Susser E. Choosing a future for epidemiology: Ⅱ. From black box to Chinese boxes and eco-epidemiology[J]. Am J Public Health, 1996, 86(5): 674-677. DOI: 10.2105/ajph.86.5.674.
[2]	Bain LE, Awah PK. Eco-epidemiology: challenges and opportunities for tomorrow's epidemiologists[J]. Pan Afr Med J, 2014, 17: 317. DOI: 10.11604/pamj.2014.17.317.4080.
[3]	Eremeeva ME, Dasch GA. Challenges posed by tick-borne rickettsiae: eco-epidemiology and public health implications[J]. Front Public Health, 2015, 3: 55. DOI: 10.3389/fpubh.2015.00055.
[4]	Moinet M, Wilkinson DA, Aberdein D, et al. Of mice, cattle, and men: a review of the eco-epidemiology of leptospira borgpetersenii serovar ballum[J]. Trop Med Infect Dis, 2021, 6(4): 189. DOI: 10.3390/tropicalmed6040189.
[5]	Matei IA, Estrada-Peña A, Cutler SJ, et al. A review on the eco-epidemiology and clinical management of human granulocytic anaplasmosis and its agent in Europe[J]. Parasit Vectors, 2019, 12(1): 1-19. DOI: 10.1186/s13071-019-3852-6.
[6]	Sato Y, Hermawan I, Kakita T, et al. Analysis of human clinical and environmental Leptospira to elucidate the eco-epidemiology of leptospirosis in Yaeyama, subtropical Japan[J]. PLos Negl Trop Dis, 2022, 16(3): e0010234. DOI: 10.1371/journal.pntd.0010234.
[7]	Nadal C, Bonnet SI, Marsot M. Eco-epidemiology of equine piroplasmosis and its associated tick vectors in Europe: A systematic literature review and a meta-analysis of prevalence[J]. Transbound Emerg Dis, 2022, 169(5): 2474-2498. DOI: 10.1111/tbed.14261.
[8]	Diuk-Wasser MA, Vanacker MC, Fernandez MP. Impact of land use changes and habitat fragmentation on the eco-epidemiology of tick-borne diseases[J]. J Med Entomol, 2021, 58(4): 1546-1564. DOI: 10.1093/jme/tjaa209.
[9]	Kirkbride JB, Jones PB. The prevention of schizophrenia-what can we learn from eco-epidemiology?[J]. Schizophr Bull, 2011, 37(2): 262-271. DOI: 10.1093/schbul/sbq120.
[10]	Babor TF. Echological validity or ecological fallacy? Toward an eco-epidemiology for alcohol studies[J]. Addiction, 2000, 95(1): 53.
[11]	Susser E. Eco-epidemiology: thinking outside the black box[J]. Epidemiology, 2004, 15(5): 519-520. DOI: 10.1097/01.ede.0000135911.42282.b4.
[12]	Göran D, Whitehead M. Policies and strategies to promote social equity in health[J]. 1991.
[13]	Coutts C, Hahn M. Green infrastructure, ecosystem services, and human health[J]. Int J Env Res Pub He, 2015, 12(8): 9768-9798. DOI: 10.3390/ijerph120809768.
[14]	Centers for Disease Control and Prevention. Social ecological model (2015)[EB/OL]. (2022-01-18)[2022-07-18]. https://www.cdc.gov/riolenceprevention/about/social-ecologicalmodel.html.
[15]	Whitmee S, Haines A, Beyrer C, et al. Safeguarding human health in the Anthropocene epoch: report of The Rockefeller Foundation-Lancet Commission on planetary health[J]. The lancet, 2015, 386(10007): 1973-2028. DOI: 10.1016/s0140-6736(15)60901-1.
[16]	Wolfson MC. POHEM: a framework for understanding and modelling the health of human populations[J]. World Health Stat Q, 1994, 47(3-4): 157-176.
[17]	Schoner J, Chapman J, Brookes A, et al. Bringing health into transportation and land use scenario planning: creating a National Public Health Assessment Model (N-PHAM)[J]. J Transp Health, 2018, 10: 401-418. DOI: 10.1016/j.jth.2018.04.008.
[18]	Calistri P, Iannetti S, L. Danzetta M, et al. The components of 'one world-one health'approach[J]. Transbound Emerg Dis, 2013, 60: 4-13. DOI: 10.1111/tbed.12145.
[19]	Woldehanna S, Zimicki S. An expanded One Health model: integrating social science and One Health to inform study of the human-animal interface[J]. Soc Sci Med, 2015, 129: 87-95. DOI: 10.1016/j.socscimed.2014.10.059.
[20]	Destoumieux-Garzón D, Mavingui P, Boetsch G, et al. The one health concept: 10 years old and a long road ahead[J]. Front Vet Sci, 2018, 12: 14. DOI: 10.3389/fvets.2018.00014.
[21]	Van Bruggen AH, Goss EM, Havelaar A, et al. One Health-Cycling of diverse microbial communities as a connecting force for soil, plant, animal, human and ecosystem health[J]. Sci Total Environ, 2019, 664: 927-937. DOI: 10.1016/j.scitotenv.2019.02.091.
[22]	March D, Susser E. The eco-in eco-epidemiology[J]. Int J Epidemiol, 2006, 35(6): 1379-1383. DOI: 10.1093/ije/dyl249.
[23]	Guhl F, Auderheide A, Ramírez JD. From ancient to contemporary molecular eco-epidemiology of Chagas disease in the Americas[J]. Int J Parasitol, 2014, 44(9): 605-612. DOI: 10.1016/j.ijpara.2014.02.005.
[24]	Rice L, Sara R. Updating the determinants of health model in the Information Age[J]. Health Promot Int, 2019, 34(6): 1241-1249. DOI: 10.1093/heapro/day064.
[25]	Shields RK, Dudley-Javoroski S. Epigenetics and the International Classification of Functioning, Disability and Health model: bridging nature, nurture, and patient-centered population health[J]. Phys Ther, 2022, 102(1): pzab247. DOI: 10.1093/ptj/pzab247.
[26]	Benis A, Tamburis O, Chronaki C, et al. One digital health: a unified framework for future health ecosystems[J]. J Med Internet Res, 2021, 23(2): e22189. DOI: 10.2196/22189.
[27]	What is One Health? One health commission[EB/OL]. (2021-12-01)[2022-07-18]. https://www.onehealthcommission.org/en/why_one_health/what_is_one_health.
[28]	World Health Organization. Integrated control of neglected zoonotic diseases in Africa: applying the one health concept[EB/OL]. (2009-04-15)[2022-07-18]. https://www.oie.int/en/for-the-media/onehealth.
[29]	One Health. World health organization[EB/OL]. (2017-09-21)[2022-07-18]. https://www.who.int/news-room/q-a-detail/one-health.
[30]	Thuemmler C, Bai C. Health 4.0: how virtualization and big data are revolutionizing healthcare \|\| security for cyber-physical systems in healthcare[J]. 2017, DOI: 10.1007/978-3-319-47617-9_12.