The prevalence and related factors of maternal anxiety and depression in Shanghai: a multicenter study based on health ecology model
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摘要:
目的 了解上海孕产妇焦虑和抑郁现状,并基于健康生态学模型系统分析其相关因素。 方法 采用多阶段分层抽样,于2022年11月―2023年4月在上海开展多中心、横断面调查。使用7项广泛性焦虑障碍量表和患者健康问卷抑郁量表评价上海孕期及产后妇女焦虑、抑郁症状检出现状,并基于健康生态学模型分析孕产期焦虑、抑郁症状的相关因素及其效应量。 结果 共收集到有效问卷1 941份,孕期891份,产后1 050份。孕期焦虑和抑郁症状检出率分别为19.5%(95% CI: 0.169~0.221)、30.4%(95% CI: 0.274~0.334);产后焦虑和抑郁症状检出率分别为18.2%(95% CI: 0.159~0.205)、23.2%(95% CI: 0.207~0.258)。二分类logistic回归分析模型分析显示,处于孕早期、怀孕次数≥2次、有精神疾病史、孕期及产后有负性事件、身体活动较少、睡眠质量较差、性格内向、生活满意度低、社会支持程度低、孕产相关知识了解程度较差、孩子性别不符合期望、产后休养条件满意程度较低的孕产妇焦虑或抑郁症状检出风险增高(均P<0.05)。 结论 上海孕产妇焦虑、抑郁症状检出率较高。焦虑、抑郁症状的影响因素是多维度的,产前和产后检查时可根据危险因素确定高危人群,开展有针对性的心理健康保健服务。 Abstract:Objective To understand the prevalence of maternal anxiety and depression in Shanghai and to explore the factors associated with them based on the Health ecology model. Methods Multistage stratified sampling method was used. A multicenter, cross-sectional survey was conducted from November 2022 to April 2023 in Shanghai. Generalized anxiety disorder-7 (GAD-7) and patient health questionnaire-9 (PHQ-9) were used to evaluate anxiety and depression symptoms of pregnant women. Related factors and their effect size were analyzed based on the health ecology model. Results A total of 1 941 valid questionnaires were collected. Among these subjects, 891 were during pregnancy and 1 050 were during postpartum. The detection rate of anxiety and depression during pregnancy were 19.5% (95% CI: 0.169-0.221) and 30.4% (95% CI: 0.274-0.334), respectively. The detection rate of postpartum anxiety and depression symptoms were 18.2% (95% CI: 0.159-0.205) and 23.2% (95% CI: 0.207-0.258), respectively. The binary logistic regression model analysis showed that being in the first trimester, gravidity≥2, with history of mental illness, negative events during and after pregnancy, inactive physical activity, worse sleep quality, introversion, lower life satisfaction, less social support, poorer pregnancy related knowledge, unfavorite baby gender, and dissatisfaction with postpartum rest conditions were significantly associated with anxiety or depression symptoms during pregnancy or postpartum (all P < 0.05). Conclusions The detection rate of anxiety and depression in pregnant and postpartum women in Shanghai are relatively high. The factors associated with anxiety and depression are multidimensional. During prenatal and postpartum examinations, close attention should be paid to women with these risk factors and targeted mental health care services should be provided. -
Key words:
- Maternal /
- Anxiety /
- Depression /
- Health ecology model /
- Related factors
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表 1 孕期焦虑、抑郁相关因素的单因素分析与多因素logistic回归分析模型
Table 1. Univariate analysis and multivariable logistic regression analysis model of related factors of anxiety and depression during pregnancy
变量Variable 总体 ②
Population ②焦虑Anxiety 抑郁Depression 有 ②
Yes ②χ2值
valueP值
value效应量
Effect
sizeaOR值value
(95% CI)有 ②
Yes ②χ2值
valueP值
value效应量
Effect
sizeaOR值value
(95% CI)个人特质Personal traits 年龄组/岁Age group/years 2.623 0.453 0.054 10.180 0.017 0.107 <25 57(6.4) 10(17.5) 1.000 23(40.4) 1.000 25~<30 308(34.6) 52(16.9) 0.795(0.327~1.934) 88(28.6) 0.604(0.288~1.266) 30~<35 376(42.2) 79(21.0) 0.900(0.369~2.193) 127(33.8) 0.712(0.337~1.504) ≥35 150(16.8) 33(22.0) 1.112(0.416~2.974) 33(22.0) 0.432(0.184~1.018) 孕期Trimester of pregnancy 4.293 0.117 0.069 1.647 0.439 0.043 孕早期First trimester 228(25.6) 44(19.3) 1.000 77(33.8) 1.000 孕中期Second trimester 288(32.3) 46(16.0) 0.647(0.381~1.098) 85(29.5) 0.708(0.450~1.112) 孕晚期Third trimester 375(42.1) 84(22.4) 0.982(0.599~1.612) 109(29.1) 0.596(0.382~0.930) 怀孕次数Number of pregnancies 9.410 0.002 0.103 1.573 0.210 0.042 1 436(48.9) 67(15.4) 1.000 124(28.4) 1.000 ≥2 455(51.1) 107(23.5) 1.562(1.015~2.401) 147(32.3) 1.345(0.921~1.962) 既往妊娠并发症
Pregnancy complication history1.843 0.175 0.045 0.017 0.897 0.004 无No 843(94.6) 161(19.1) 1.000 256(30.4) 1.000 有Yes 48(5.4) 13(27.1) 0.906(0.418~1.964) 15(31.3) 0.713(0.327~1.553) 妊娠计划内Pregnancy plan 0.080 0.777 0.009 1.077 0.299 0.035 否No 223(25.0) 45(20.2) 1.000 74(33.2) 1.000 是Yes 668(75.0) 129(19.3) 1.454(0.923~2.289) 197(29.5) 1.109(0.744~1.653) 精神疾病史
History of mental illness2.852 0.091 0.057 7.811 0.005 0.094 否No 876(98.3) 168(19.2) 1.000 261(29.8) 1.000 是Yes 15(1.7) 6(40.0) 3.516(0.982~12.590) 10(66.7) 5.816(1.412~23.963) 睡眠质量Sleep 23.687 < 0.001 0.163 89.789 < 0.001 0.317 非常好Very good 89(10.0) 7(7.9) 1.000 11(12.4) 1.000 好Good 283(31.8) 42(14.8) 2.211(0.836~5.848) 50(17.7) 1.568(0.701~3.508) 一般General 427(47.9) 95(22.2) 3.191(1.233~8.261) 151(35.4) 3.488(1.606~7.577) 不好/非常不好
Poor/Very poor92(10.3) 30(32.6) 4.130(1.452~11.748) 59(64.1) 11.944(4.895~29.144) 个体的行为生活
方式及心理特征
Behavior and lifestyles and
psychologicalcharacteristics身体活动Physical activity 4.628 0.328 0.072 13.769 0.008 0.124 从不/每周<1 d
Never/Less than
1 day per week356(40.0) 77(21.6) 1.000 130(36.5) 1.000 每周1~2 d 1-2 day per week 247(27.7) 45(18.2) 0.791(0.488~1.282) 67(27.1) 0.623(0.407~0.954) 每周3~4 d 3-4 day per week 148(16.6) 31(21.0) 0.927(0.539~1.594) 41(27.7) 0.713(0.432~1.177) 每周5~6 d 5-6 day per week 62(7.0) 12(19.4) 0.682(0.302~1.539) 19(30.7) 0.735(0.364~1.483) 每天Everyday 78(8.8) 9(11.5) 0.472(0.202~1.106) 14(18.0) 0.425(0.204~0.883) 孕产相关知识
Maternity related knowledge4.419 0.220 0.070 21.099 < 0.001 0.154 非常了解Very familiar 58(6.5) 9(15.5) 1.000 6(10.3) 1.000 较为了解Relatively familiar 269(30.2) 56(20.8) 1.841(0.699~4.847) 67(24.9) 3.887(1.348~11.208) 一般General 376(42.2) 81(21.5) 1.643(0.630~4.285) 129(34.3) 5.319(1.869~15.137) 不太了解/非常不了解
Relatively unfamiliar/
Very unfamiliar188(21.1) 28(14.9) 0.811(0.288~2.284) 69(36.7) 4.409(1.491~13.032) 艾森克内外向分量表①
Score of Eysenck
personality questionnaire ①9(6,11) 8(5,10) < 0.001 0.389 0.927(0.869~0.990) 8(5,10) < 0.001 0.410 0.947(0.892~1.005) 生活满意度
Score of satisfaction
with life scale26(22,30) 23(20,27) < 0.001 0.319 0.934(0.901~0.970) 24(20,28) < 0.001 0.328 0.935(0.903~0.967) 家庭和社区的人际网络
Interpersonal network of
family and community婚姻状况Marital status 0.009 0.924 0.003 1.870 0.171 0.046 在婚不分居Married 854(95.8) 167(19.6) 1.000 256(30.0) 1.000 分居/离婚/丧偶/未婚
Separated/Divorced/
Widowed /Unmarried37(4.2) 7(18.9) 0.887(0.318~2.470) 15(40.5) 0.954(0.407~2.240) 孕期负性事件
Negative events
during pregnancy31.560 < 0.001 0.188 46.908 < 0.001 0.229 否No 753(84.5) 123(16.3) 1.000 195(25.9) 1.000 是Yes 138(15.5) 51(37.0) 1.925(1.216~3.049) 76(55.1) 2.607(1.670~4.070) 社会支持 ①
Score of social
support rate scale ①43(37,48) 38(34,44) < 0.001 0.336 0.948(0.920~0.976) 40(35,44) < 0.001 0.340 0.962(0.937~0.988) 生活和工作条件
Living and working conditions学历Education level 0.984 0.611 0.033 1.000 0.606 0.034 高中及以下
Senior high school or below173(19.4) 30(17.3) 1.000 58(33.5) 1.000 大专/职大
Junior college/
Vocational university193(21.7) 36(18.7) 1.691(0.891~3.208) 58(30.1) 1.353(0.775~2.363) 大学及以上University or above 525(58.9) 108(20.6) 1.763(0.971~3.200) 155(29.5) 1.444(0.860~2.425) 工作状况Working status 1.928 0.381 0.047 4.154 0.125 0.068 是Yes 538(60.4) 99(18.4) 1.000 155(28.8) 1.000 休假Maternity leave 176(19.8) 34(19.3) 0.920(0.553~1.529) 51(29.0) 1.043(0.658~1.653) 无职业Unemployed 177(19.9) 41(23.2) 1.528(0.909~2.569) 65(36.7) 1.386(0.866~2.219) 居住条件Living condition 22.325 < 0.001 0.158 19.976 < 0.001 0.150 非常满意Very satisfied 189(21.2) 23(12.2) 1.000 38(20.1) 1.000 满意Satisfied 453(50.8) 83(18.3) 1.118(0.613~2.039) 134(29.6) 1.033(0.617~1.730) 一般General 225(25.3) 57(25.3) 1.081(0.549~2.126) 90(40.0) 1.003(0.557~1.807) 不满意/非常不满意
Unsatisfied/Very unsatisfied24(2.7) 11(45.8) 2.170(0.705~6.685) 9(37.5) 0.514(0.165~1.597) 自觉经济压力Economic pressure 37.243 < 0.001 0.204 26.786 < 0.001 0.173 完全没压力No pressure at all 36(4.0) 3(8.3) 1.000 6(16.7) 1.000 几乎没压力Almost no pressure 121(13.6) 17(14.0) 1.073(0.257~4.489) 26(21.5) 1.002(0.302~3.320) 一般General 523(58.7) 85(16.3) 1.018(0.258~4.017) 152(29.1) 1.034(0.333~3.217) 较有压力A little stressful 182(20.4) 55(30.2) 1.710(0.419~6.986) 69(37.9) 1.108(0.340~3.614) 非常有压力Very stressful 29(3.3) 14(48.3) 3.624(0.744~17.644) 18(62.1) 3.031(0.737~12.467) 当地、国家、全球的
文化、政策环境
Local, national, and global
culture and policy孕妇学校参与度
Maternity school participation3.532 0.473 0.063 8.952 0.062 0.100 全程参加Attend all courses 31(3.5) 6(19.4) 1.000 6(19.4) 1.000 参加大部分课程
Attend most courses81(9.1) 17(21.0) 0.450(0.133~1.523) 19(23.5) 0.578(0.170~1.963) 参加一半课程
Attend half courses43(4.8) 13(30.2) 1.074(0.301~3.835) 14(32.6) 1.014(0.278~3.693) 参加少部分课程
Attend a few courses180(20.2) 34(18.9) 0.498(0.160~1.550) 45(25.0) 0.646(0.208~2.003) 未参加
Did not attend any courses556(62.4) 104(18.7) 0.462(0.157~1.362) 187(33.6) 0.818(0.277~2.413) 注:①使用Mann-Whitney U检验;②以人数(占比/%)或M(P25,P75)表示。
Note: ① Mann-Whitney U test; ② Number of people (proportion/%) or M(P25,P75).表 2 产后焦虑、抑郁相关因素的单因素分析与多因素logistic回归分析模型分析
Table 2. Univariate analysis and multivariable logistic regression analysis model of related factors of anxiety and depression during postpartum
变量Variable 总体 ②
Population ②焦虑Anxiety 抑郁Depression 有 ②
Yes ②χ2值
valueP值
value效应量
Effect
sizeaOR值value
(95% CI)有 ②
Yes ②χ2值
valueP值
value效应量
Effect
sizeaOR值value
(95% CI)个人特质Personal traits 年龄组/岁Age group/years 1.252 0.741 0.035 5.266 0.153 0.071 <25 53(5.0) 12(22.6) 1.000 11(20.8) 1.000 25~<30 318(30.3) 61(19.2) 1.044(0.425~2.566) 88(27.7) 2.211(0.854~5.726) 30~<35 461(43.9) 81(17.6) 1.093(0.439~2.717) 96(20.8) 1.555(0.593~4.082) ≥35 218(20.8) 37(17.0) 1.050(0.393~2.807) 49(22.5) 1.708(0.614~4.746) 产后时期/月Postpartum period/months 4.360 0.037 0.064 3.553 0.059 0.058 <1 631(60.1) 102(16.16) 1.000 134(21.2) 1.000 1~2 419(39.9) 89(21.24) 1.374(0.942~2.004) 110(26.3) 1.218(0.843~1.759) 怀孕次数
Number of pregnancies1.469 0.226 0.037 3.749 0.053 0.060 1 602(57.3) 117(19.4) 1.000 153(25.4) 1.000 ≥2 448(42.7) 74(16.5) 0.701(0.454~1.083) 91(20.3) 0.627(0.412~0.954) 此次妊娠并发症
Pregnancy complication0.882 0.348 0.029 0.420 0.517 0.020 否No 797(75.9) 150(18.8) 1.000 189(23.7) 1.000 是Yes 253(24.1) 41(16.2) 0.725(0.462~1.138) 55(21.7) 0.858(0.559~1.318) 分娩中疼痛程度
Pain level during delivery12.147 0.007 0.108 9.401 0.024 0.095 完全不痛Completely painless 90(8.6) 9(10.0) 1.000 12(13.3) 1.000 不太痛Painless 87(8.3) 13(14.9) 1.024(0.363~2.890) 15(17.2) 1.078(0.397~2.927) 一般General 198(18.9) 26(13.1) 0.833(0.332~2.085) 43(21.7) 1.709(0.737~3.962) 较痛/非常痛
Painful/Very painful675(64.3) 143(21.2) 1.541(0.691~3.435) 174(25.8) 1.821(0.856~3.875) 此次分娩孩子健康状况
Health status of offspring4.515 0.034 0.066 1.674 0.196 0.040 健康Health 936(89.1) 162(17.3) 1.000 212(22.7) 1.000 疾病Disease 114(10.9) 29(25.4) 1.188(0.683~2.067) 32(28.1) 0.830(0.473~1.457) 妊娠计划内Pregnancy plan 3.383 0.066 0.057 7.228 0.007 0.083 否No 208(19.8) 47(22.6) 1.000 63(30.3) 1.000 是Yes 842(80.2) 144(17.1) 0.959(0.605~1.523) 181(21.5) 0.768(0.493~1.196) 个人特质Personal traits 精神疾病史
History of mental illness6.172 0.013 0.077 3.645 0.056 0.059 否No 1 041(99.1) 186(17.9) 1.000 239(23.0) 1.000 是Yes 9(0.9) 5(55.6) 7.829(1.683~36.424) 5(55.6) 7.053(1.400~35.530) 睡眠质量Sleep 60.682 < 0.001 0.240 131.243 < 0.001 0.354 非常好Very good 99(9.4) 4(4.0) 1.000 7(7.1) 1.000 好Good 293(27.9) 28(9.6) 1.622(0.509~5.165) 23(7.8) 0.635(0.233~1.725) 一般General 502(47.8) 104(20.7) 3.177(1.037~9.731) 132(26.3) 2.553(1.012~6.442) 不好/非常不好Poor/Very poor 156(14.9) 55(35.3) 3.452(1.071~11.128) 82(52.6) 4.220(1.593~11.176) 个体的行为生活方式
及心理特征
Behavior and lifestyles and
psychological characteristics身体活动Physical activity 4.249 0.514 0.064 16.951 0.005 0.127 从不Never 128(12.2) 28(21.9) 1.000 40(31.3) 1.000 每周<1 d
Less than 1 day per week204(19.4) 37(18.1) 0.916(0.479~1.752) 54(26.5) 0.870(0.477~1.586) 每周1~2 d 1-2 days per week 300(28.6) 61(20.3) 1.171(0.639~2.146) 70(23.3) 0.752(0.422~1.338) 每周3~4 d 3-4 days per week 200(19.0) 32(16.0) 0.923(0.475~1.795) 48(24.0) 1.002(0.546~1.839) 每周5~6 d 5-6 days per week 92(8.8) 15(16.3) 0.948(0.423~2.128) 18(19.4) 0.706(0.328~1.519) 每天Everyday 126(12.0) 18(14.3) 0.935(0.427~2.049) 14(11.1) 0.323(0.140~0.747) 孕产相关知识
Maternity related knowledge56.475 < 0.001 0.232 52.071 < 0.001 0.223 非常了解Very familiar 122(11.6) 8(6.6) 1.000 14(11.5) 1.000 较为了解Relatively familiar 497(47.3) 65(13.1) 1.603(0.685~3.754) 84(16.9) 1.167(0.558~2.444) 一般General 380(36.2) 95(25.0) 2.748(1.171~6.446) 123(32.4) 1.698(0.811~3.557) 不太了解/非常不了解
Relatively unfamiliar/
Very unfamiliar51(4.9) 23(45.1) 5.832(2.008~16.941) 23(45.1) 2.005(0.717~5.605) 艾森克内外向分量表①
Score of Eysenck
personality questionnaire ①8(5,10) 7(3,9) < 0.001 0.363 0.928(0.877~0.981) 6(3,9) < 0.001 0.327 0.895(0.848~0.945) 生活满意度
Score of satisfaction
with life scale26(21,30) 21(19,25) < 0.001 0.284 0.948(0.914~0.982) 22(20,25) < 0.001 0.267 0.944(0.912~0.977) 家庭和社区的人际网络
Interpersonal network
of family and community婚姻状况Marital status 0.019 0.889 0.004 0.032 0.858 0.006 在婚不分居Married 1 032(98.3) 187(18.1) 1.000 239(23.2) 1.000 分居/离婚/丧偶/未婚
Separated/Divorced/
Widowed /Unmarried18(1.7) 4(22.2) 1.042(0.283~3.828) 5(27.8) 1.295(0.349~4.800) 怀孕后负性事件
Negative events since pregnancy39.145 < 0.001 0.193 38.184 < 0.001 0.191 否No 914(87.0) 140(15.3) 1.000 184(20.1) 1.000 是Yes 136(13.0) 51(37.5) 1.789(1.095~2.921) 60(44.1) 1.659(1.014~2.715) 社会支持_实际获得 ①
Score of postpartum
support questionnaire ①188(163,215) 170(140,198) < 0.001 0.326 0.994(0.989~1.000) 167(142,191) < 0.001 0.301 0.991(0.985~0.996) 生活和工作条件
Living and working conditions学历Education level 4.341 0.114 0.064 0.304 0.859 0.017 高中及以下
Senior high school or below149(14.2) 33(22.1) 1.000 33(22.1) 1.000 大专/职大
Junior college/
Vocational university228(21.7) 32(14.0) 0.528(0.273~1.019) 51(22.4) 1.057(0.553~2.021) 大学及以上University or above 673(64.1) 126(18.7) 0.699(0.378~1.294) 160(23.8) 1.003(0.535~1.882) 工作状况Work status 2.499 0.287 0.049 1.128 0.569 0.033 产假Maternity leave 883(84.1) 158(17.9) 1.000 208(23.6) 1.000 返岗工作Returning to work 16(1.5) 1(6.3) 0.203(0.022~1.899) 2(12.5) 0.299(0.053~1.705) 无职业Unemployed 151(14.4) 32(21.2) 0.972(0.534~1.767) 34(22.5) 0.809(0.447~1.465) 自觉经济压力Economic pressure 27.085 < 0.001 0.161 50.649 < 0.001 0.220 完全没压力/几乎没压力
No pressure at all/
Almost no pressure174(16.6) 13(7.5) 1.000 16(9.2) 1.000 一般General 582(55.4) 101(17.4) 1.089(0.533~2.224) 121(20.8) 0.926(0.475~1.807) 较有压力A little stressful 259(24.7) 66(25.5) 1.359(0.633~2.918) 92(35.5) 1.589(0.777~3.247) 非常有压力Very stressful 35(3.3) 11(31.4) 1.021(0.326~3.200) 15(42.9) 1.249(0.426~3.663) 产后休养条件满意度
Living condition90.864 < 0.001 0.294 116.087 < 0.001 0.333 非常满意Very satisfied 237(22.6) 20(8.4) 1.000 21(8.9) 1.000 满意Satisfied 549(52.3) 73(13.3) 0.934(0.511~1.706) 101(18.4) 1.425(0.782~2.598) 一般General 245(23.3) 88(35.9) 1.839(0.952~3.550) 110(44.9) 2.633(1.365~5.080) 不满意/非常不满意
Unsatisfied/Very unsatisfied19(1.8) 10(52.6) 1.848(0.541~6.320) 12(63.2) 2.292(0.621~8.457) 当地、国家、全球的
文化、政策环境
Local, national and
global culture and policy孕妇学校参与度
Maternity school participation0.709 0.950 0.026 1.717 0.788 0.040 全程参加
Attend all courses110(10.5) 17(15.5) 1.000 22(20.0) 1.000 参加大部分课程
Attend most courses149(14.2) 27(18.1) 1.091(0.507~2.348) 31(20.8) 0.923(0.438~1.946) 参加一半课程
Attend half courses51(4.9) 9(17.6) 0.825(0.299~2.276) 11(21.6) 0.841(0.316~2.238) 参加少部分课程
Attend a few courses171(16.3) 31(18.1) 0.731(0.341~1.571) 42(24.6) 0.881(0.423~1.832) 未参加
Did not attend any courses569(54.2) 107(18.8) 0.588(0.301~1.149) 138(24.3) 0.684(0.359~1.305) 对孩子性别满意程度
Attitude towards
children′s gender18.786 < 0.001 0.134 17.362 < 0.001 0.129 满意Satisfie 737(70.2) 112(15.2) 1.000 148(20.1) 1.000 较满意Relatively satisfied 69(6.6) 23(33.3) 2.403(1.264~4.567) 27(39.1) 2.323(1.220~4.421) 无所谓/不太满意
General/Relatively satisfied244(23.2) 56(23.0) 1.003(0.652~1.543) 69(28.3) 0.878(0.575~1.340) 注:①使用Mann-Whitney U检验;②以人数(占比/%)或M(P25,P75)表示。
Note: ① Mann-Whitney U test; ② Number of people (proportion/%) or M(P25,P75). -
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