Research progress in the study of HPV E2, E5 oncogenic mechanism and related vaccine
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摘要: 宫颈癌是影响女性的常见恶性肿瘤之一,其中高危型HPV的持续感染是导致宫颈癌的主要病因。在宫颈癌的发生发展过程中,除了HPV E6、E7与宫颈癌病变有主要的关系外,其他一些早期蛋白如E2、E5也发挥了重要的作用。如E2可以启动并维持病毒的复制,而E5可以与E6、E7癌蛋白合作,促进感染细胞增殖。本研究仅就HPV E2、E5在宫颈癌发生发展中的机制以及相关的治疗性疫苗研究进展进行综述。Abstract: Cervical cancer is one of the common malignancies affecting women worldwide, of which persistent infection with high-risk human papillomavirus (HPV) is the main cause. In the occurrence and development of cervical cancer, in addition to HPV E6, E7 and cervical cancer lesions have a major relationship, some other early proteins such as E2 and E5 also play an essential role. For example, E2 can initiate and maintain viral replication, and E5 can cooperate with E6 and E7 oncoproteins to promote proliferation of infected cells. In this paper, we aim to review the current research progress on the mechanism of HPV E2 and E5 proteins in the development of cervical cancer and the progress of research on E2 and E5 related therapeutic vaccines.
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Key words:
- Cervical cancer /
- Human papillomavirus /
- E2 protein /
- E5 protein /
- Vaccine
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