• 中国精品科技期刊
  • 《中文核心期刊要目总览》收录期刊
  • RCCSE 中国核心期刊(5/114,A+)
  • Scopus收录期刊
  • 美国《化学文摘》(CA)收录期刊
  • WHO 西太平洋地区医学索引(WPRIM)收录期刊
  • 《中国科学引文数据库(CSCD)》核心库期刊 (C)
  • 中国科技核心期刊
  • 中国科技论文统计源期刊
  • 《日本科学技术振兴机构数据库(中国)》(JSTChina)收录期刊
  • 美国《乌利希期刊指南》(UIrichsweb)收录期刊
  • 中华预防医学会系列杂志优秀期刊(2019年)

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

甘肃省6~12岁儿童甲状腺容积影响因素及不同甲状腺容积校正方法比较

徐利花 费秀兰 陈发青 李青林 孙玮 王涛 王燕玲

徐利花, 费秀兰, 陈发青, 李青林, 孙玮, 王涛, 王燕玲. 甘肃省6~12岁儿童甲状腺容积影响因素及不同甲状腺容积校正方法比较[J]. 中华疾病控制杂志, 2024, 28(8): 917-921. doi: 10.16462/j.cnki.zhjbkz.2024.08.008
引用本文: 徐利花, 费秀兰, 陈发青, 李青林, 孙玮, 王涛, 王燕玲. 甘肃省6~12岁儿童甲状腺容积影响因素及不同甲状腺容积校正方法比较[J]. 中华疾病控制杂志, 2024, 28(8): 917-921. doi: 10.16462/j.cnki.zhjbkz.2024.08.008
XU Lihua, FEI Xiulan, CHEN Faqing, LI Qinglin, SUN Wei, WANG Tao, WANG Yanling. Influencing factors of thyroid volume in children aged 6-12 years in Gansu Province and comparison of different thyroid volume correction methods[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(8): 917-921. doi: 10.16462/j.cnki.zhjbkz.2024.08.008
Citation: XU Lihua, FEI Xiulan, CHEN Faqing, LI Qinglin, SUN Wei, WANG Tao, WANG Yanling. Influencing factors of thyroid volume in children aged 6-12 years in Gansu Province and comparison of different thyroid volume correction methods[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(8): 917-921. doi: 10.16462/j.cnki.zhjbkz.2024.08.008

甘肃省6~12岁儿童甲状腺容积影响因素及不同甲状腺容积校正方法比较

doi: 10.16462/j.cnki.zhjbkz.2024.08.008
基金项目: 

甘肃省卫生行业科研计划项目 GSWSKY2021-008

详细信息
    通讯作者:

    王燕玲,E-mail : wylxiao@126.com

  • 中图分类号: R153.2;R181.2

Influencing factors of thyroid volume in children aged 6-12 years in Gansu Province and comparison of different thyroid volume correction methods

Funds: 

Gansu Provincial Health Industry Scientific Research Program Project GSWSKY2021-008

More Information
  • 摘要:   目的  分析甘肃省6~12岁儿童甲状腺容积的影响因素,探讨适宜的甲状腺容积校正方法。  方法  根据甘肃省2019年碘缺乏病监测结果,选择碘营养适宜的武威市凉州区和平凉市崆峒区作为调查点。采用多阶段分层抽样方法抽取非寄宿制6~12岁儿童(地区、性别比例均衡),测量儿童的身高、体重、甲状腺容积、尿碘和所在家庭食用盐盐碘。分析儿童甲状腺容积影响因素,比较体质容积指数(body mass volume index, BMIV)、体表面积容积指数(body surface area volume index, BSAV)、体重身高容积指数(weight height volume index, WHVI)、身高容积指数1(height volume index1, HVI1)和身高容积指数2(height volume index2, HVI2)对甲状腺容积校正的效果。  结果  不同性别儿童甲状腺容积差异无统计学意义(Z=-0.837, P=0.403)。Spearman秩相关分析显示身高、体重、BMI、体表面积(body surface area, BSA)、年龄、尿碘与甲状腺容积均呈正相关(均P<0.001)。其中,BSA与甲状腺容积相关性最强(r=0.787)。分位数回归分析显示年龄和BSA对甲状腺容积整体分布均有影响。通过身高、体重与校正后甲状腺容积的Spearman秩相关分析显示BSAV可最大程度减小身高、体重对甲状腺容积的影响。  结论  年龄和BSA均影响甲状腺容积。BSAV对儿童甲状腺容积校正效果较好,建议将其作为儿童甲状腺容积的评价指标。
  • 表  1  各调查点基本情况

    Table  1.   Basic information of each survey point

    地区 District 例数 Number of case MUIC /(μg·L-1) 碘盐覆盖率 Iodised salt coverage rate/% 合格碘盐食用率 Qualified iodised salt consumption rate/%
    武威市 Wuwei City
      城市 Urban 408 278.6 100.0 77.0
      农村 Rural 429 251.2 99.5 73.2
    平凉市 Pingliang City
      城市 Urban 412 237.4 99.0 86.4
      农村 Rural 417 240.0 100.0 95.0
    合计 Total 1 666 252.5 99.6 82.8
    注:MUIC,尿碘中位数。
    Note: MUIC, median urinary iodine concentration.
    下载: 导出CSV

    表  2  6~12岁儿童甲状腺容积检查结果

    Table  2.   Results of thyroid volume examination in children aged 6-12 years old

    年龄/岁 Age/years 男生 Boys 女生 Girls 合计 Total
    例数 Number of case M(P25, P75) /mL 例数 Number of case M(P25, P75) /mL 例数 Number of case M(P25, P75) /mL
    6 117 1.9(1.7, 2.5) 115 1.9(1.5, 2.4) 232 1.9(1.6, 2.4)
    7 126 2.1(1.7, 2.6) 122 2.1(1.9, 2.6) 248 2.1(1.8, 2.6)
    8 127 2.5(2.2, 3.0) 119 2.5(2.2, 3.0) 246 2.5(2.2, 3.0)
    9 118 3.0(2.6, 3.4) 119 2.9(2.4, 3.6) 237 3.0(2.6, 3.5)
    10 125 3.5(2.9, 4.3) 120 3.3(2.7, 3.9) 245 3.3(2.8, 4.1)
    11 123 4.0(3.4, 4.5) 117 4.0(3.5, 4.9) 240 4.0(3.4, 4.7)
    12 112 4.4(3.7, 5.1) 106 4.4(3.8, 5.3) 218 4.4(3.7, 5.2)
    合计 Total 848 3.0(2.3, 3.9) 818 2.9(2.2, 3.9) 1 666 2.9(2.2, 3.9)
    下载: 导出CSV

    表  3  甲状腺容积与体格发育指标和尿碘的相关性分析

    Table  3.   Correlation analysis between thyroid volume and physical development indicators and urinary iodine

    变量 Variable r值 value P值 value
    年龄/岁 Age/ years 0.744 < 0.001
    体重 Weight/kg 0.769 < 0.001
    身高 Height/cm 0.761 < 0.001
    BMI/(kg·m-2) 0.544 < 0.001
    BSA/m2 0.787 < 0.001
    尿碘 Urinary iodine/(μg·L-1) 0.090 < 0.001
    注:BSA,体表面积。
    Note: BSA, body surface area.
    下载: 导出CSV

    表  4  6~12岁儿童甲状腺容积影响因素多元线性回归分析

    Table  4.   Multiple linear regression analysis of influencing factors of thyroid volume in children aged 6-12 years

    因素 Factor 未标准化系数Unstandardised coefficient 标准化系数β值 Standardized β value t值value P值value
    β值 value 标准误差 Standard error
    常量 Constant -1.885 0.106 -17.823 <0.001
    BSA/m2 3.189 0.147 0.539 21.736 <0.001
    年龄/岁 Age/years 0.176 0.016 0.280 11.325 <0.001
    尿碘 Urinary iodine/(μg·L-1) <0.001 <0.001 -0.002 -0.151 0.880
    注:BSA,体表面积;―,无法获取
    Note: BSA, body surface area;―,unavailable.
    下载: 导出CSV

    表  5  6~12岁儿童身高与校正前后甲状腺容积的Spearman相关性分析

    Table  5.   Spearman correlation analysis between of height and thyroid volume before and after correction in children aged 6-12 years old

    年龄/岁 Age/years 甲状腺容积 Thyroid volume BMIV BSAV WHVI HVI1 HVI2
    r值 value P值 value r值 value P值 value r值 value P值 value r值 value P值 value r值 value P值 value r值 value P值 value
    6 0.195 0.003 0.060 0.364 -0.096 0.145 -0.393 <0.001 0.060 0.365 -0.091 0.165
    7 0.173 0.006 0.073 0.254 -0.096 0.133 -0.356 <0.001 0.040 0.535 -0.104 0.103
    8 0.282 <0.001 0.074 0.247 -0.119 0.061 -0.460 <0.001 0.100 0.116 -0.098 0.124
    9 0.381 <0.001 0.206 0.001 0.010 0.883 -0.357 <0.001 0.194 0.003 0.005 0.943
    10 0.451 <0.001 0.258 <0.001 0.073 0.257 -0.335 <0.001 0.277 <0.001 0.092 0.149
    11 0.426 <0.001 0.197 0.002 -0.030 0.645 -0.416 <0.001 0.231 <0.001 -0.022 0.739
    12 0.349 <0.001 0.190 0.005 0.02 0.774 -0.316 <0.001 0.193 0.004 0.018 0.791
    注:BMIV,体质容积指数;BSAV,体表面积容积指数;WHVI,体重身高容积指数;HVI1,身高容积指数1;HVI2,身高容积指数2。
    Note: BMIV, body mass volume index; BSAV, body surface area volume index; WHVI, weight height volume index; HVI1, height volume index1; HVI2, height volume index2.
    下载: 导出CSV

    表  6  6~12岁儿童体重与校正前后甲状腺容积的Spearman相关性分析

    Table  6.   Spearman correlation analysis between of weight and thyroid volume before and after correction in children aged 6-12 years

    年龄/岁 Age/years 甲状腺容积 Thyroid volume BMIV BSAV WHVI HVI1 HVI2
    r值 value P值 value r值 value P值 value r值 value P值 value r值 value P值 value r值 value P值 value r值 value P值 value
    6 0.416 <0.001 -0.026 0.696 0.028 0.668 -0.355 <0.001 0.294 <0.001 0.161 0.014
    7 0.379 <0.001 -0.024 0.712 0.033 0.600 -0.335 <0.001 0.275 <0.001 0.162 0.011
    8 0.418 <0.001 -0.095 0.138 -0.022 0.726 -0.469 <0.001 0.295 <0.001 0.151 0.018
    9 0.461 <0.001 -0.088 0.176 0.016 0.803 -0.450 <0.001 0.355 <0.001 0.221 0.001
    10 0.551 <0.001 -0.013 0.839 0.137 0.031 -0.414 <0.001 0.463 <0.001 0.337 <0.001
    11 0.480 <0.001 -0.110 0.088 0.011 0.865 -0.479 <0.001 0.358 <0.001 0.209 0.001
    12 0.427 <0.001 -0.131 0.053 0.020 0.763 -0.433 <0.001 0.336 <0.001 0.228 0.001
    注:BMIV,体质容积指数;BSAV,体表面积容积指数;WHVI,体重身高容积指数;HVI1,身高容积指数1;HVI2,身高容积指数2。
    Note: BMIV, body mass volume index; BSAV, body surface area volume index; WHVI, weight height volume index; HVI1, height volume index1; HVI2, height volume index2.
    下载: 导出CSV
  • [1] Gyamfi D, Wiafe Ya, Ofori Awuah E, et al. Goitre prevalence and urinary iodine concentration in school-aged children in the Ashanti region of Ghana[J]. Int J Endocrinol, 2020, 20203759786. DOI: 10.1155/2020/3759786.
    [2] Chen W, Zhang Q, Wu Y, et al. Shift of reference values for thyroid volume by ultrasound in 8-to13-year-olds with sufficient iodine intake in China[J]. Thyroid, 2019, 29(3): 405-411. DOI: 10.1089/thy.2018.0412.
    [3] 中华人民共和国卫生部. 地方性甲状腺肿诊断准(WS 276-2007)[M]. 北京: 中国标准出版社, 2007: 1-4.

    Ministry of Health of the People′s Republic of China. Diagnostic criteria for endemic goiter (WS 276-2007)[M]. Beijing: China Standard Press, 2007: 1-4.
    [4] Liu L, Qian T, Sun R, et al. Comparative analysis of five correction methods for thyroid volume by ultrasound and their recommended reference values in Chinese children aged 8-10 years[J]. Br J Nutr, 2022: 1-28. DOI: 10.1017/s0007114522001003.
    [5] 宋选波, 李津蜀, 张莉莉, 等. 四川省8~10岁儿童甲状腺容积相关影响因素分析及不同甲状腺容积指数比较[J]. 中华地方病学杂志, 2022, 41(8): 664-668. DOI: 10.3760/cma.j.cn231583-20211008-00338.

    Song XB, Li JS, Zhang LL, et al. Analysis of thyroid volume-related influencing factors and comparison of different thyroid volume indices in children aged 8-10 years in Sichuan Province[J]. Chin J Endemiol, 2022, 41(8): 664-668. DOI: 10.3760/cma.j.cn231583-20211008-00338.
    [6] 窦瑜贵, 王燕玲, 曹永琴, 等. 2019年甘肃省碘缺乏病监测结果分析[J]. 中华地方病学杂志, 2022, 41(4): 284-289. DOI: 10.3760/cma.j.cn231583-20210302-00060.

    Dou YG, Wang YL, Cao YQ, et al. Analysis of iodine deficiency disease monitoring results in Gansu Province in 2019[J]. Chin J Endemiol, 2022, 41(4): 284-289. DOI: 10.3760/cma.j.cn231583-20210302-00060.
    [7] 中华人民共和国国家卫生和计划生育委员会. 尿中碘的测定第1部分: 砷铈催化分光光度法(WS/T 107.1-2016)[M]. 北京: 中国标准出版社, 2016: 1-5.

    National Health and Family Planning Commission of the People′s Republic of China. Determination of iodine in urine part 1: Arsenic-cerium catalyzed spectrophotometric method (WS/T 107.1-2016)[M]. Beijing: China Standard Press, 2016: 1-5.
    [8] Unicef Ouncf, Ign Oign. Guidance on the monitoring of salt iodization programmes and determination of population iodine status: russian language version[J]. Clinical and Experimental Thyroidology, 2018, 14(2): 100-112. DOI: 10.14341/ket9734.
    [9] 中华人民共和国国家质量监督检验检疫总局, 中国国家标准化管理委员会. 制盐工业通用试验方法碘的测定(GB/T 13025. 7-2012)[M]. 北京: 中国标准出版社, 2013: 1-3.

    General Administration of Quality Supervision, Inspection and Quarantine of the People′s Republic of China, Standardization Administration of the People′s Republic of China. General test method for salt industry determination of iodine (GB/T 13025.7-2012)[M]. Beijing: China Standard Press, 2013: 1-3.
    [10] 中华人民共和国卫生部. 食品安全国家标准食用盐碘含量(GB 26878-2011)[M]. 北京: 中国标准出版社, 2011: 1-1.

    Ministry of Health of the People′s Republic of China. National standards for food safety-iodine content of edible salt (GB 26878-2011)[M]. Beijing: Standards Press of China, 2011: 1-1.
    [11] Zimmermann Michael B, Hess Sonja Y, Molinari L, et al. New reference values for thyroid volume by ultrasound in iodine-sufficient schoolchildren: a World Health Organization/Nutrition for health and development iodine deficiency study group report[J]. Am J Clin Nutr, 2004, 79(2): 231-237. DOI: 10.1093/ajcn/79.2.231.
    [12] Liu L, Liu L, Li M, et al. Study on association between height, weight, iodine supplementation and thyroid volume[J]. Br J Nutr, 2022, 127(9): 1358-1366. DOI: 10.1017/s0007114521002622.
    [13] An S, Li W, Wang X, et al. Study on influential factors and reference values for thyroid volume in Chinese children aged 6-12 years[J]. Br J Nutr, 2022: 1-9. DOI: 10.1017/s0007114522002070.
    [14] Cui Y, Wang Y, Zhang D, et al. Reference intervals for thyroid hormones and thyroid volume in children aged 7~13 years from iodine-sufficient areas in Tianjin, China[J]. Biol Trace Elem Res, 2023, 201(12): 5575-5584. DOI: 10.1007/s12011-023-03624-0.
    [15] 张根红, 王羽. 非缺碘性因素对儿童甲状腺容积影响的研究[J]. 中国地方病学杂志, 2000, 19(2): 2. DOI: 10.3760/cma.j.issn.1000-4955.2000.02.019.

    Zhang GH, Wang Y. Study on the effect of non-iodine deficiency factors on thyroid volume in children[J]. Chin J Endemiol, 2000, 19(2): 2. DOI: 10.3760/cma.j.issn.1000-4955.2000.02.019.
    [16] 王木华, 季淑眯, 陈迪群, 等. 福建省8~10岁儿童不同甲状腺容积校正指数结果比较[J]. 中华疾病控制杂志, 2023, 27(9): 1010-1012. DOI: 10.16462/j.cnki.zhjbkz.2023.09.004.

    Wang MH, Ji SM, Chen DQ, et al. Comparison of the results of different thyroid volume correction indices in children aged 8-10 years in Fujian Province[J]. Chin J Dis Control Prev, 2023, 27(9): 1010-1012. DOI: 10.16462/j.cnki.zhjbkz.2023.09.004.
  • 加载中
计量
  • 文章访问数:  29
  • HTML全文浏览量:  13
  • PDF下载量:  3
  • 被引次数: 0
出版历程
  • 收稿日期:  2024-01-18
  • 修回日期:  2024-05-17
  • 网络出版日期:  2024-09-29
  • 刊出日期:  2024-08-10

目录

    /

    返回文章
    返回