Investigation of awareness and vaccination willingness for recombinant zoster vaccine among 50 years adults in Wuzhong District, Suzhou
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摘要:
目的 了解苏州市吴中区≥50岁成人对重组带状疱疹疫苗(recombinant zoster vaccine, RZV)的知晓、接种意愿率及其影响因素。 方法 从江苏省预防接种综合服务管理信息系统中导出苏州市吴中区长桥辖区≥50岁常住居民的相关数据，按照年龄分层(50~＜60岁、60~＜70岁、≥70岁)1∶15的比例，随机抽取1 267人纳入本研究，2022年8月采用电话询问方式开展问卷调查。计算RZV知晓及接种意愿率，采用logistic回归分析模型分析其影响因素。 结果 在1 147名研究对象中，男性516名(45.0%)，女性631名(55.0%)。研究对象RZV知晓率为41.33%(n=474)，接种意愿率为28.95%(n=332)。多因素logistic回归分析模型分析结果显示，年龄、职业、婚姻状况、家庭成员有带状疱疹(herpes zoster, HZ)既往史等是影响RZV知晓的主要因素。女性(OR=1.683, 95% CI: 1.234~2.296)、家庭成员中有医务人员(OR=1.778, 95% CI: 1.175~2.690)、关系密切的朋友中有医务人员(OR=1.956, 95% CI: 1.115~3.434)、HZ既往史(OR=1.944, 95% CI: 1.366~2.767)、家庭成员中有HZ既往史(OR=2.337, 95% CI: 1.698~3.218)、三价或四价流感病毒裂解疫苗(简称流感疫苗)接种史(OR=2.549, 95% CI: 1.813~3.582)、知晓RZV(OR=4.431, 95% CI: 3.235~6.069)是RZV接种意愿的促进因素(均P＜0.05)。 结论 苏州市吴中区≥50岁成人RZV知晓率及接种意愿率均较低，女性、家庭成员中有医务人员、关系密切的朋友中有医务人员、自己或者家庭成员有HZ既往史等均是RZV接种意愿的促进因素。 Abstract:Objective To investigate the awareness and vaccination willingness rates of recombinant zoster vaccine (RZV) and the influencing factors among adults aged ≥50 years in Wuzhong District, Suzhou City. Methods Residents aged 50 years in Changqiao Sub-district of Wuzhong District were exported from Jiangsu Province vaccination integrated service management information system. According to the proportion of 1/15 of age stratification (50- < 60, 60- < 70, 70 and above), 1 267 people were randomly selected as the survey sample to participate in the telephone questionnaire survey in August 2022.The awareness and vaccination willingness rates of RZV were calculated, and the influencing factors were analyzed by logistic regression model. Results Among 1 147 respondents, 516 (45.0%) were males, and the 60-69 age group accounted for the largest proportion (40.2%). The rates of awareness and vaccination willingness of RZV were 41.33% (n=474) and 28.95% (n=332), respectively. The results of multivariate logistic regression showed that age, occupation, marital status, history of herpes zoster in family members and relatives and friends were associated with the awareness of RZV0. Females (OR=1.683, 95% CI: 1.234-2.296), participants having family members (OR=1.778, 95% CI: 1.175-2.690) and close friends being medical workers (OR=1.956, 95% CI: 1.115-3.434), history of HZ (OR=1.944, 95% CI: 1.366-2.767), and having family members with history of HZ (OR=2.337, 95% CI: 1.698-3.218), history of trivalent or quadrivalent influenza vaccine(split virion), inactivated (influenza vaccine for short) (OR=2.549, 95% CI: 1.813-3.582), and awareness of RZV (OR=4.431, 95% CI: 3.235-6.069) were willing to get RZV (all P < 0.05). Conclusions The rates of awareness and vaccination willingness of RZV are low. Female, having medical workers in family members and close friends, HZ history among participants and family members are promoting factors for RZV vaccination willingness. -
Key words:
- Recombinant zoster vaccine /
- Awareness rate /
- Vaccination willingness
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表 1 不同特征研究对象RZV知晓情况的比较
Table 1. Comparison of RZV awareness among participants with different characteristics
变量Variable 总人数Total numberof people 知晓人数Number ofknown persons 知晓率Awarenessrate /% χ2值value P值value 性别Gender 0.22 0.881 男性Male 516 212 41.09 女性Female 631 262 41.52 年龄/岁Age / years 17.36 ＜0.001 50~＜60 418 203 48.56 60~＜70 461 160 34.71 ≥70 268 111 41.42 职业Career 45.91 ＜0.001 非医务人员Non-medical personnel 1 065 411 38.59 医务工作者Medical workers 82 63 76.83 婚姻状况Marital status 6.29 0.012 已婚 1 071 453 42.30 未婚/离婚/丧偶Unmarried/divorce/widowed 76 21 27.63 家庭成员中是否有医务人员Are there any medical personnel in the family 33.62 ＜0.001 否No 187 113 60.43 是Yes 960 361 37.60 关系密切的朋友中是否有医务人员Whether there are medical personnel among close friends 57.08 ＜0.001 否No 151 105 69.54 是Yes 996 369 37.05 水痘既往史History of varicella 9.95 0.007 否或不清楚No or unclear 197 99 50.25 是Yes 950 375 39.47 HZ既往史History of herpes zoster 32.57 ＜0.001 否No 236 136 57.63 是Yes 911 338 37.10 家庭成员HZ既往史History of herpes zoster in family members 82.87 ＜0.001 否No 392 234 59.69 是Yes 755 240 31.79 流感疫苗接种史History of flu vaccination 12.94 0.003 否No 384 187 48.70 是Yes 763 287 37.61 23价肺炎球菌多糖疫苗接种史History of pneumonia vaccine 23 9.68 0.019 否No 280 138 49.29 是Yes 867 336 38.75 基础病史Basic medical history 5.03 0.377 否No 552 223 40.40 是Yes 595 251 42.18 注：RZV，重组带状疱疹疫苗；HZ，带状疱疹。
Note: RZV, recombinant zoster vaccine; HZ, herpes zoster.
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表 2 不同特征研究对象RZV知晓情况的比较
Table 2. Comparison of RZV awareness among participants with different characteristics
变量Variable 单因素Single factor 多因素Multiple factors OR值value(95% CI) P值value OR值value(95% CI) P值value 性别Gender 男性Male 1.000 1.000 女性Female 1.018(0.804 ~ 1.290) 0.881 0.994(0.764 ~ 1.293) 0.964 年龄/岁Age/years 50~＜60 1.000 1.000 60~＜70 0.563(0.429 ~ 0.738) ＜0.001 0.529(0.347 ~ 0.806) 0.003 ≥70 0.749(0.549 ~ 1.021) 0.067 0.919(0.628 ~ 1.345) 0.664 职业Career 非医务人员Non-medical personnel 1.000 1.000 医务人员Medical workers 5.276(3.113 ~ 8.943) ＜0.001 2.630(1.298 ~ 5.326) 0.007 婚姻状况Marital status 已婚Married 1.000 1.000 未婚/离婚/丧偶Unmarried/divorce/widowed 0.521(0.311 ~ 0.874) 0.014 0.394(0.216 ~ 0.716) 0.002 家庭成员中是否有医务人员Are there any medical personnel in the family 否No 1.000 1.000 是Yes 2.534(1.838 ~ 3.492) ＜0.001 1.571(1.079 ~ 2.289) 0.019 关系密切的朋友中是否有医务人员Whether there are medical personnel among close friends 否No 1.000 1.000 是Yes 3.878(2.680 ~ 5.613) ＜0.001 1.936(1.160 ~ 3.233) 0.012 水痘既往史History of varicella 否或不清楚No or unclear 1.000 1.000 是Yes 1.549(1.138 ~ 2.108) 0.005 1.016(0.695 ~ 1.487) 0.933 HZ既往史History of herpes zoster 否No 1.000 1.000 是Yes 2.306(1.723 ~ 3.085) ＜0.001 2.132(1.541 ~ 2.948) ＜0.001 家庭成员HZ既往史History of herpes zoster in family members 否No 1.000 1.000 是Yes 3.178(2.466 ~ 4.094) ＜0.001 3.249(2.447 ~ 4.314) ＜0.001 流感疫苗接种史History of flu vaccination 否No 1.000 1.000 是Yes 1.574(1.229 ~ 2.017) ＜0.001 1.332(0.994 ~ 1.785) 0.055 23价肺炎球菌多糖疫苗接种史History of pneumonia vaccine 23 否No 1.000 1.000 是Yes 1.536(1.171 ~ 2.014) 0.002 1.833(1.290 ~ 2.605) 0.001 基础疾病病史Basic medical history 否No 1.000 1.000 是Yes 1.076(0.851 ~ 1.362) 0.539 1.032(0.769 ~ 1.384) 0.835 注：RZV，重组带状疱疹疫苗；HZ，带状疱疹。
Note: RZV, recombinant zoster vaccine; HZ, herpes zoster.
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表 3 不同特征的研究对象RZV的接种率及未来接种愿意情况的比较
Table 3. Comparison of vaccination rate and future willingness of RZV among participants with different characteristics
变量Variable 总人数Total numberof people 已接种人数Number ofvaccinatedpersons 接种率Vaccinationrate /% P值value 未来愿意接种人数Number of peoplewilling to be vaccinatedin the future 接种意愿率Vaccinationrate /% P值value 性别Gender 0.001 0.001 男性Male 516 43 8.33 123 23.84 女性Female 631 93 14.74 209 33.12 年龄/岁Age /years 0.004 ＜0.001 50~＜60 418 60 14.35 153 36.60 60~＜70 461 37 8.03 98 21.26 ≥70 268 39 14.55 81 30.22 职业Career 0.245 ＜0.001 非医务人员Non-medical personnel 1 065 123 11.55 294 27.61 医务人员Medical workers 82 13 15.85 38 46.34 婚姻状况Marital status 0.273 0.999 已婚Married 1 071 124 11.58 310 28.94 未婚/离婚/丧偶Unmarried/divorce/widowed 76 12 15.79 22 28.95 家庭成员中是否有医务人员Are there any medical professionals in your family 0.150 ＜0.001 否No 187 28 14.97 90 48.13 是Yes 960 108 11.25 242 25.21 关系密切的朋友中是否有医务人员Whether there are medical personnel among close friends 0.099 ＜0.001 否No 151 24 15.89 77 50.99 是Yes 996 112 11.24 255 25.60 水痘既往史History of varicella 0.017 ＜0.001 否或不清楚No or unclear 197 31 15.74 82 41.62 是Yes 950 105 11.05 250 26.32 HZ既往史History of herpes zoster 0.007 ＜0.001 否No 236 40 16.95 108 45.76 是Yes 911 96 10.54 224 24.59 家庭成员HZ既往史History of herpes zoster in family members ＜0.001 ＜0.001 否No 392 75 19.13 179 45.66 是Yes 755 61 8.08 153 20.26 流感疫苗接种史History of flu vaccination ＜0.001 ＜0.001 否No 384 73 19.01 163 42.45 是Yes 763 63 8.26 169 22.15 23价肺炎球菌多糖疫苗接种史History of pneumonia vaccine 23 ＜0.001 0.001 否No 280 60 21.43 104 37.14 是Yes 867 76 8.77 228 26.30 是否知晓RZV Are you familiar with RZV ＜0.001 ＜0.001 否No 474 133 28.06 239 50.42 是Yes 673 3 0.45 93 13.82 基础疾病病史Basic medical history 0.056 0.125 否No 552 55 9.96 148 26.81 是Yes 595 81 13.61 184 30.92 注：RZV，重组带状疱疹疫苗；HZ，带状疱疹。
Note: RZV, recombinant zoster vaccine; HZ, herpes zoster.
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表 4 RZV未来接种愿意影响因素的logistic回归分析
Table 4. Logistic regression analysis of influencing factors of future willingness to RZV
变量Variable 单因素Single factor 多因素Multiple factors OR值value(95% CI) P值value OR值value(95% CI) P值value 性别Gender 男性Male 1.000 1.000 女性Female 1.582(1.218~2.056) 0.001 1.683(1.234~2.296) 0.001 年龄/岁Age/years 50~＜60 1.000 1.000 60~＜70 0.468(0.347~0.631) ＜0.001 0.478(0.294~0.777) 0.003 ≥70 0.750(0.540~1.041) 0.086 1.111(0.707~1.744) 0.648 职业Career 非医务人员Non-medical personnel 1.000 1.000 医务人员Medical workers 2.265(1.438~3.568) ＜0.001 0.558(0.271~1.149) 0.113 家庭成员中是否有医务人员Are there any medical professionals in your family 否No 1.000 1.000 是Yes 2.753(1.995~3.798) ＜0.001 1.778(1.175~2.690) 0.006 关系密切的朋友中是否有医务人员Whether there are medical personnel among close friends 否No 1.000 1.000 是Yes 3.024(2.132~4.288) ＜0.001 1.956(1.115~3.434) 0.019 婚姻状况Marital status 已婚Married 1.000 1.000 未婚/离婚/丧偶Unmarried/divorce/widowed 1.000(0.599~1.671) 1.000 1.048(0.548~2.003) 0.887 水痘既往史History of varicella 否或不清楚No or unclear 1.000 1.000 是Yes 1.997(1.453~2.745) ＜0.001 1.288(0.853~1.945) 0.229 HZ既往史History of herpes zoster 否No 1.000 1.000 是Yes 2.588(1.923~3.484) ＜0.001 1.944(1.366~2.767) ＜0.001 家庭成员HZ既往史History of herpes zoster in family members 否No 1.000 1.000 是Yes 3.307(2.533~4.316) ＜0.001 2.337(1.698~3.218) ＜0.001 流感疫苗接种史History of flu vaccination 否No 1.000 1.000 是Yes 2.592(1.989~3.378) ＜0.001 2.549(1.813~3.582) ＜0.001 23价肺炎疫苗接种史History of pneumonia vaccine 23 否No 1.000 1.000 是Yes 1.656(1.245~2.204) 0.001 1.381(0.911~2.092) 0.128 是否知晓RZV Are you familiar with RZV 否No 1.000 1.000 是Yes 6.342(4.777~8.421) ＜0.001 4.431(3.235~6.069) ＜0.001 基础疾病病史Basic medical history 否No 1.000 1.000 是Yes 0.818(0.633~1.057) 0.125 0.729(0.516~1.030) 0.073 注：RZV，重组带状疱疹疫苗；HZ，带状疱疹。
Note: RZV, recombinant zoster vaccine; HZ, herpes zoster.
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