膳食炎症指数与血清C反应蛋白关联性的Meta分析

马润泽; 巴合古·依明尼亚孜; 顾园申; 赵辉; 阿娜尔·高少; 余文慧; 戴江红

doi:10.16462/j.cnki.zhjbkz.2024.09.017

膳食炎症指数与血清C反应蛋白关联性的Meta分析

doi: 10.16462/j.cnki.zhjbkz.2024.09.017

新疆医科大学公共卫生学院，乌鲁木齐 830017

基金项目:

国家自然科学基金 82360662

国家自然科学基金 82160640

科技创新团队“天山创新团队”项目 2022TSYCTD0013

详细信息

通讯作者:
戴江红，E-mail: epi102@sina.com

中图分类号: R151;R181
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- 文章访问数: 57
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- 被引次数: 0
出版历程
- 收稿日期: 2024-04-03
- 修回日期: 2024-07-25
- 网络出版日期: 2024-10-24
- 刊出日期: 2024-09-10

Association between dietary inflammation index and serum C reactive protein level: a Meta-analysis

School of Public Health, Xinjiang Medical University, Urumqi 830017, China

Funds:

National Natural Science Foundation of China 82360662

National Natural Science Foundation of China 82160640

Scientific and Technological Innovation Team "Tianshan Innovation Team" Project 2022TSYCTD0013

More Information

Corresponding author: DAI Jianghong, E-mail: epi102@sina.com

摘要

摘要: 目的系统评价膳食炎症指数(dietary inflammatory index, DII)与血清C反应蛋白(C-reactive protein, CRP)的关联性。方法检索PubMed、Web of Science和EMBASE数据库，收集有关DII与CRP关联性研究资料，检索时限从建库至2023年10月1日。由两名独立研究者进行文献筛选、数据提取、质量评价，采用R 4.2.2软件进行统计分析，并利用亚组分析、Meta回归分析探索异质性来源。结果共纳入20项研究，其中包括15项横断面研究、1项病例对照研究、3项队列研究、1项随机对照试验，累计纳入研究对象59 953例。Meta回归分析结果显示，DII与血清CRP水平相关(OR=1.205, 95% CI: 1.101~1.319)。通过基于研究类型、年龄分布、样本量、DII与膳食调查方法的亚组分析后，I²降低(P>0.1)。结论 DII与血清CRP水平相关。研究类型、年龄分布、样本量、DII与膳食调查方法的不同可能是影响各研究间异质性的主要因素。
- 膳食炎症指数 /
- C反应蛋白 /
- Meta分析 /
- 慢性低度炎症
Abstract: Objective To systematically evaluate the association between the dietary inflammatory index (DII) and serum C-reactive protein (CRP) levels. Methods A search of the PubMed, Web of Science, and EMBASE databases was conducted to collect studies examining the association between the DII and CRP. The search period extended from the inception of each database until October 1, 2023. Two independent researchers performed the literature screening, data extraction, and quality assessment. Statistical analyses were conducted using R software version 4.2.2, and subgroup analyses and Meta-regression were utilized to explore the sources of heterogeneity among studies. Results A total of 20 studies were included, comprising 15 cross-sectional studies, 1 case-control study, 3 cohort studies, and 1 randomized controlled trial, with a cumulative total of 59 953 participants. The Meta-analysis indicated a significant association between the DII and serum CRP levels (OR=1.205, 95% CI: 1.101~1.319). After conducting subgroup analyses based on study design, age distribution, sample size, DII calculation methods, and dietary assessment techniques, the I² statistic was reduced (P>0.1). Conclusions Current evidence suggests that the DII may be associated with serum CRP levels. Differences in study design, age distribution, sample size, DII calculation methods, and dietary assessment techniques may be the primary factors contributing to the heterogeneity observed among the studies.
- Dietary inflammation index /
- C-reactive protein /
- Meta-analysis /
- Chronic low-grade inflammation

HTML全文

图 1 研究纳入流程图

Figure 1. Research into the flow chart

下载: 全尺寸图片幻灯片

图 2 膳食炎症指数与血清C反应蛋白关联性的森林图

Figure 2. Forest plot of association between dietary inflammation index and serum C-reactive protein

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图 3 漏斗图与填补漏斗图

A，漏斗图；B，填补漏斗图。

Figure 3. Funnel plot and funnel plot after filling

A, funnel plot; B, funnel plot after filling.

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表 1 纳入研究的基本特征与质量评价

Table 1. Research basic information and quality evaluation

第一作者 First author	年份 Year	研究类型 Type of study	样本量 Sample size	人群 Participants	年龄/岁 Age/years	膳食调查方法 Dietary survey methods	质量 Quantity
Lazarou^[12]	2010	横断面研究 Cross-sectional study	83	儿童 Children	9.2±1.7	食物频率问卷 Food frequency questionnaire	高 High
Shivappa^[13]	2014	队列研究 Cohort study	641	成年人 Adult	20~70	24 h膳食回顾调查 24 h dietary record	高 High
Wirth MD^[14]	2014	横断面研究 Cross-sectional study	447	警察 Policemen	42.4±8.5	食物频率问卷 Food frequency questionnaire	高 High
Shivappa^[15]	2015	队列研究 Cohort study	2 524	成年人	35~55	食物频率问卷 Food frequency questionnaire	高 High
Wirth^[16]	2017	横断面研究 Cross-sectional study	329	非洲裔美国人 African American	54.8±11.4	食物频率问卷 Food frequency questionnaire	高 High
Shivappa^[17]	2017	横断面研究 Cross-sectional study	7 215	成年人 Adult	>19	24 h膳食回顾调查 24 h dietary record	高 High
Julia^[18]	2017	队列研究 Cohort study	1 980	成年人 Adult	35~60	24 h膳食回顾调查 24 h dietary record	中 Middle
Shin D^[19]	2017	横断面研究 Cross-sectional study	561	孕妇 Maternal	27.5±1.4	24 h膳食回顾调查 24 h dietary record	高 High
Na^[20]	2018	横断面研究 Cross-sectional study	28 086	成年人 Adult	40~79	24 h膳食回顾调查 24 h dietary record	高 High
Almeida-de-Souza^[21]	2018	横断面研究 Cross-sectional study	329	青少年 Adolescents	12~18	食物频率问卷 Food frequency questionnaire	高 High
Ren^[22]	2018	横断面研究 Cross-sectional study	1 086	成年人 Adult	>19	24 h膳食回顾调查 24 h dietary record	中 Middle
Shivappa^[23]	2019	横断面研究 Cross-sectional study	5 292	成年人 Adult	>19	24 h膳食回顾调查 24 h dietary record	高 High
Turner-McGrievy^[24]	2019	随机对照临床试验 Randomized controlled trial	98	成年人 Adult	≥21	24 h膳食回顾调查 24 h dietary record	高 High
Shin^[25]	2019	横断面研究 Cross-sectional study	3 014	成年人 Adult	>19	24 h膳食回顾调查 24 h dietary record	中 Middle
Yang^[26]	2020	横断面研究 Cross-sectional study	2 898	孕妇 Maternal	28.34±3.12	24 h膳食回顾调查 24 h dietary record	高 High
Suzuki^[27]	2020	横断面研究 Cross-sectional study	1 176	成年人 Adult	>19	食物频率问卷 Food frequency questionnaire	中 Middle
Yang^[28]	2020	横断面研究 Cross-sectional study	307	成年人 Adult	>19	称重法 Weighing	中 Middle
Son^[29]	2021	病例对照研究 Case-control study	1 254	老年人 The elderly	74.6±5.5	简易自记膳食法 Brief-type self-administered diet history questionnaire	中 Middle
Malcomson^[30]	2021	横断面研究 Cross-sectional study	75	成年人 Adult	>19	食物频率问卷 Food frequency questionnaire	中 Middle
Hart^[31]	2021	横断面研究 Cross-sectional study	2 558	成年人 Adult	>19	24 h膳食回顾调查 24 h dietary record	高 High

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表 2 纳入研究的亚组分析与Meta回归分析

Table 2. Subgroup analysis of included studies and Meta-regression analysis

亚组 Subgroup	研究数量 Number of study	OR值 value (95% CI)	异质性检验 Heterogeneity test		Meta回归分析 Meta-regression analysis
亚组 Subgroup	研究数量 Number of study	OR值 value (95% CI)	I²/%	P值 value	Meta回归分析 Meta-regression analysis
研究设计类型 Type of study					0.288
横断面研究 Cross-sectional	15	1.252(1.116~1.405)	99	< 0.001
病例对照研究 Case-control	1	1.170(1.131~1.211)
队列研究 Cohort	3	1.051(0.971~1.138)	51	0.130
随机对照试验 randomized controlled trial	1	1.490(0.931~2.384)
年龄分布/岁 Age distribution/years					0.628
<19	2	1.260(1.041~1.524)	0	0.390
≥19	18	1.205(1.101~1.319)	99	< 0.001
性别分布 Gender distribution					0.848
全人群 Whole crowd	18	1.208(1.100~1.325)	99	< 0.001
女性 Female	2	1.279(0.672~2.435)	77	0.040
样本量 Sample size					< 0.001
<100	3	1.560(1.139~2.138)	91	< 0.001
100~<1 000	6	1.193(1.034~1.376)	54	0.050
≥1 000	11	1.100(1.052~1.151)	91	< 0.001
DII					0.847
DII	17	1.205(1.101~1.363)	99	< 0.001
E-DII	2	1.155(1.111~1.200)	31	< 0.230
C-DII	1	1.231(1.010~1.500)
血清炎症指标 Serum inflammatory markers					0.868
CRP	10	1.221(1.101~1.319)	98	< 0.001
hs-CRP	10	1.128(1.067~1.193)	92	< 0.001
膳食调查方法 Dietary survey method					0.147
食物频率 Food frequency	7	1.368(1.098~1.703)	96	< 0.001
24 h膳食回顾24 h dietary record	11	1.107(1.079~1.135)	20	0.260
其他 Other	2	1.086(0.940~1.254)	99	< 0.001
注：DII，膳食炎症指数；E-DII，能量调整膳食炎症指数；C-DII，儿童膳食炎症指数；CRP，C反应蛋白；hs-CRP，超敏C反应蛋白。 Note: DII, dietary inflammation index; E-DII, energy-adjusted dietary inflammation index; C-DII, children′s dietary inflammation index; CRP, C-reactive protein; hs-CRP, high sensitivity C-reactive protein.

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