2019―2023年潍坊市女性人乳头瘤病毒感染特征

杨浩然; 王伟华; 孙玲玲; 宋信杰; 杨晓; 李京; 徐健

doi:10.16462/j.cnki.zhjbkz.2025.03.004

2019―2023年潍坊市女性人乳头瘤病毒感染特征

doi: 10.16462/j.cnki.zhjbkz.2025.03.004

杨浩然^{1, 2},
王伟华³,
孙玲玲⁴,
宋信杰⁵,
杨晓¹,
李京^2, ,,
徐健^3, ,

1.
山东第二医科大学护理学基础教研室, 潍坊 261053
2.
山东第二医科大学公共卫生学院预防医学系, 潍坊 261053
3.
潍坊市妇幼保健院检验科, 潍坊 261000
4.
潍坊市妇幼保健院产科, 潍坊 261000
5.
潍坊市奎文区疾病预防控制中心慢性病防治科, 潍坊 261031

基金项目:

潍坊市2021年科技发展计划(医学类)项目 2021YX047

山东省教育督导学会 SDJYDDXH2023-2159

山东省教育督导学会 SDJYDDXH2023-1008

详细信息

通讯作者:
徐健，E-mail: ydukongjian@163.com

李京，E-mail: lijing@sdsmu.edu.cn

中图分类号: R737.33;R181
计量
- 文章访问数: 37
- HTML全文浏览量: 20
- PDF下载量: 4
- 被引次数: 0
出版历程
- 收稿日期: 2024-08-28
- 修回日期: 2024-12-02
- 刊出日期: 2025-03-10

Characteristics of human papilloma virus infection in female in Weifang from 2019 to 2023

YANG Haoran^{1, 2},
WANG Weihua³,
SUN Lingling⁴,
SONG Xinjie⁵,
YANG Xiao¹,
LI Jing^{2
, ,},
XU Jian^{3
, ,}

1.
Department of Basic Teaching and Research of Nursing, Shandong Second Medical University, Weifang 261053, China
2.
Department of Preventive Medicine, School of Public Health, Shandong Second Medical University, Weifang 261053, China
3.
Department of Clinical Laboratory, Weifang Maternal and Child Health Hospital, Weifang 261000, China
4.
Department of Obstetrics, Weifang Maternal and Child Health Hospital, Weifang 261000, China
5.
Department of Chronic Disease Prevention and Control, Weifang Kuiwen Center for Disease Control and Prevention, Weifang 261031, China

Funds:

Weifang Science and Technology Development Plan 2021 (Medical) Project 2021YX047

Shandong Provincial Education Supervision Association SDJYDDXH2023-2159

Shandong Provincial Education Supervision Association SDJYDDXH2023-1008

More Information

Corresponding author: LI Jing, E-mail: lijing@sdsmu.edu.cn; XU Jian, E-mail: ydukongjian@163.com

摘要

摘要: 目的分析2019―2023年潍坊市≥18岁女性人乳头瘤病毒(human papilloma virus, HPV)感染及亚型分布特征，为防治HPV提供科学依据。方法选取2019年1月―2023年12月在潍坊市某三甲医院健康体检中心进行HPV检测的42 849例女性作为研究对象，基于Joinpoint回归模型分析不同年龄组HPV感染率变化趋势，采用聚类分析研究HPV亚型感染率的分布特征。结果 HPV总感染率为20.66%，高危型HPV感染率为15.65%，在感染的HPV类型中，感染率前5位依次为HPV52、16、58、51、68;低危型HPV感染率为5.01%，在感染的HPV类型中，感染率前3位依次为HPV53、81、42。不同年龄组中，18~＜25岁和≥55岁年龄组HPV感染率较高，分别为32.95%和25.81%。感染类型以单一感染为主(70.05%)，其次是双重感染(20.43%)。Joinpoint回归结果显示，25~＜35岁和45~＜55岁年龄组HPV感染率呈下降趋势(均P＜0.05)，各年龄组均无转折点。聚类分析表明，HPV16、52为高感染组，58、42、81、53、51为中感染组，剩余16种亚型为低感染组。结论 2019―2023年潍坊市女性HPV感染率较高，以单一、高危型HPV感染为主; 感染人群以18~＜25岁和≥55岁为主。应重点关注18~＜25岁、≥55岁女性宫颈癌筛查情况，积极开展女性健康教育宣传活动，提高女性宫颈癌的防治意识，预防宫颈癌的发生。
- 人乳头瘤病毒 /
- 宫颈癌 /
- 人乳头瘤病毒感染 /
- 基因亚型
Abstract: Objective To analyze the prevalence and subtype distribution of HPV infections among ≥18-year-old women in the Weifang area, and to provide scientific evidence for the prevention and treatment of HPV. Methods A total of 42 849 women who underwent HPV testing at an outpatient health examination center in a tertiary hospital in Weifang City from January 2019 to December 2023 were included in this study. The Joinpoint regression model was utilized to analyze the trends in HPV infection rates across different age groups, and cluster analysis was employed to investigate the distribution characteristics of HPV subtype infection rates. Results The overall HPV infection rate was 20.66%, with the rate of high-risk HPV infections being 15.65%. The top five HPV subtypes in terms of infection rates were HPV52, 16, 58, 51, and 68 among the type of HPV infected; for low-risk HPV infections, the rates were 5.01%, with HPV53, 81, and 42 being the most prevalent. In different age groups, the highest infection rates were observed in those 18- < 25 years old and ≥55 years old, at 32.95% and 25.81%, respectively. The majority of infections were single infections (70.05%), followed by dual infections (20.43%). Joinpoint regression indicated a decreasing trend in HPV infection rates in the 25- < 35 and 45- < 55 age groups (all P < 0.05), with no turning points observed in any age group. Cluster analysis revealed that HPV16 and 52 were in the high-infection group, while 58, 42, 81, 53, and 51 were in the medium-infection group, and the remaining 16 subtypes were classified as low-infection group. Conclusions The HPV infection rate in the Weifang area is relatively high, predominantly characterized by single and high-risk HPV infections, with 18- < 25 years old and ≥55 years old women being the primary affected groups. Attention should be focused on cervical cancer screening for women aged 18 to < 25 and ≥ 55, and actively carry out women's health education and promotional activities to raise awareness of cervical cancer prevention and treatment among women, in order to prevent the occurrence of cervical cancer.
- Human papilloma virus /
- Cervical cancer /
- Human papilloma virus infection /
- Gene subtype

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图 1 HPV亚型分布特征

a: 高危型HPV；b：低危型HPV；HPV，人乳头瘤病毒。

Figure 1. Distribution characteristics of HPV subtypes

a: high-risk HPV; b: low-risk HPV; HPV, human papilloma virus.

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图 2 2019―2023年不同年龄组人乳头瘤病毒感染率变化趋势

a: P＜0.05

Figure 2. Time trends in human papilloma virus infection rates in different age groups from 2019 to 2023

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图 3 各年龄组HPV亚型分布

HPV：人乳头瘤病毒。

Figure 3. Distribution characteristics of HPV subtypes in different age groups

HPV: human papilloma virus.

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表 1 23种HPV亚型感染率年度分布情况

Table 1. Time trend analysis of infection rate of 23 HPV subtypes among women in Weifang City from 2019 to 2023

HPV亚型HPVsubtypes	2019年year^①	2020年year^①	2021年year^①	2022年year^①	2023年year^①	合计Total^①	χ²值value	P值value
52	306(4.02)	278(3.95)	335(4.11)	356(4.34)	340(3.09)	1 615(3.77)	14.93	0.005
16	291(3.83)	236(3.35)	251(3.08)	281(3.42)	253(2.30)	1 312(3.06)	34.66	＜0.001
58	222(2.92)	151(2.14)	209(2.56)	223(2.72)	211(1.92)	1 016(2.37)	19.97	0.001
53	180(2.37)	164(2.33)	171(2.10)	176(2.14)	189(1.72)	880(2.05)	12.41	0.015
51	154(2.02)	144(2.04)	184(2.26)	155(1.89)	153(1.39)	790(1.84)	22.80	＜0.001
68	127(1.67)	114(1.62)	123(1.51)	113(1.38)	118(1.07)	595(1.39)	16.80	0.002
56	110(1.44)	98(1.39)	128(1.57)	111(1.35)	114(1.04)	561(1.31)	11.91	0.018
59	112(1.47)	97(1.38)	93(1.14)	105(1.28)	111(1.01)	518(1.21)	9.74	0.045
66	104(81.37)	95(1.35)	94(1.15)	106(1.29)	100(0.91)	499(1.16)	9.87	0.043
18	112(1.47)	80(1.14)	86(1.05)	78(0.95)	85(0.77)	441(1.03)	24.97	＜0.001
33	99(1.30)	68(0.97)	74(0.91)	90(1.10)	73(0.66)	404(0.94)	18.40	0.001
31	90(1.18)	71(1.01)	94(1.15)	77(0.94)	71(0.64)	403(0.94)	19.41	0.001
39	79(1.04)	68(0.97)	84(1.03)	80(0.97)	77(0.70)	388(0.91)	7.64	0.106
35	64(0.84)	47(0.67)	58(0.71)	40(0.49)	65(0.59)	274(0.61)	12.58	0.014
45	35(0.46)	27(0.38)	25(0.31)	31(0.38)	35(0.32)	153(0.36)	3.46	0.485
82	12(0.16)	11(0.16)	20(0.25)	28(0.34)	30(0.27)	101(0.24)	6.34	0.175
73	18(0.24)	18(0.26)	16(0.20)	15(0.18)	19(0.17)	86(0.20)	2.66	0.617
83	7(0.09)	9(0.13)	11(0.13)	8(0.10)	13(0.12)	48(0.11)	1.51	0.824
81	151(1.99)	141(2.00)	195(2.40)	203(2.47)	182(1.65)	872(2.03)	12.06	0.017
42	119(1.56)	138(1.96)	154(1.89)	153(1.86)	149(1.35)	713(1.66)	11.75	0.019
43	120(1.58)	93(1.32)	121(1.48)	96(1.17)	94(0.85)	524(1.22)	26.77	＜0.001
6	68(0.89)	59(0.84)	88(1.08)	71(0.86)	86(0.78)	372(0.87)	6.27	0.180
11	56(0.74)	44(0.62)	43(0.53)	42(0.51)	31(0.28)	216(0.50)	20.75	＜0.001
合计Total	1 781(23.42)	1 560(22.22)	1 856(22.79)	1 811(19.28)	1 846(17.27)	8 854(20.66)	154.05	＜0.001
注：HPV, 人乳头瘤病毒。 ①以人数(占比/%)表示。 Note: HPV, human papilloma virus. ① Number of people (proportion/%).

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表 2 感染者的年龄分布

Table 2. Age distribution of infected people

年龄/岁Age/years	人数Number of people	HPV感染HPV infection^①	HR-HPV感染HR-HPV infection^①	LR-HPV感染LR-HPV infection^①
18~＜25	3 511	1 157(32.95)	923(26.29)	234(6.66)
25~＜35	19 625	3 750(19.11)	2 888(14.72)	862(4.39)
35~＜45	11 731	2 120(18.07)	1 536(13.09)	584(4.98)
45~＜55	5 681	1 233(21.70)	876(15.42)	357(6.28)
≥55	2 301	594(25.81)	484(21.03)	110(4.78)
合计Total	42 849	8 854(20.66)	6 707(15.65)	2 147(5.01)
χ²值value		444.51	422.79	55.59
P值value		＜0.001	＜0.001	＜0.001
注：HPV，人乳头瘤病毒；HR-HPV，高危型HPV；LR-HPV，低危型HPV。 ①人数(占比/%)表示。 Note: HPV, human papilloma virus; HR-HPV, high-risk HPV; LR-HPV, low-risk HPV. ① Number of people (proportion/%).

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表 3 2019―2023年不同年龄组HPV感染率趋势的Joinpoint回归

Table 3. Joinpoint regression model of HPV infection trends in different age groups from 2019 to 2023

年龄组/岁Age group/years	APC(95% CI)/%	t值value	P值value
18~＜25	-2.93(-6.83~1.25)	-1.30	0.194
25~＜35	-7.65(-10.97~-4.73)	-5.49	0.001
35~＜45	-8.18(-21.70~5.16)	-3.16	0.168
45~＜55	-7.24(-12.53~-1.99)	-2.67	0.005
≥55	1.63(-1.28~4.70)	0.99	0.271
注：HPV, 人乳头瘤病毒; APC, 年度变化百分比。 Note: HPV, human papilloma virus; APC, annual percent change.

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表 4 8 854例HPV感染者多重感染状况

Table 4. Multiple infection status of 8 854 individuals infected with HPV

年份Year	人数Number of people	单一感染Single infection^①	多重感染Multiple infections^①
年份Year	人数Number of people	单一感染Single infection^①	双重Double	三重Triple	四重及以上Quadruple and above
2019	7 604	1 212(15.94)	379(4.98)	131(1.72)	59(0.78)
2020	7 021	1 086(15.47)	330(4.70)	93(1.32)	51(0.73)
2021	8 144	1 314(16.13)	364(4.47)	121(1.49)	57(0.70)
2022	9 392	1 255(13.36)	380(4.05)	116(1.24)	60(0.64)
2023	10 688	1 335(12.49)	356(3.33)	103(0.96)	52(0.49)
合计	42 849	6 202(14.47)	1 809(4.22)	564(1.32)	279(0.65)
χ²值		80.26	37.84	23.18	7.24
P值		< 0.001	< 0.001	< 0.001	0.124
注：HPV, 人乳头瘤病毒。 ①以人数(占比/%)表示。 Note: HPV, human papilloma virus. ① Number of people (proportion/%).

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2019―2023年潍坊市女性人乳头瘤病毒感染特征

doi: 10.16462/j.cnki.zhjbkz.2025.03.004

通讯作者:
徐健，E-mail: ydukongjian@163.com

李京，E-mail: lijing@sdsmu.edu.cn

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Characteristics of human papilloma virus infection in female in Weifang from 2019 to 2023

Corresponding author: LI Jing, E-mail: lijing@sdsmu.edu.cn; XU Jian, E-mail: ydukongjian@163.com

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2019―2023年潍坊市女性人乳头瘤病毒感染特征

doi: 10.16462/j.cnki.zhjbkz.2025.03.004

通讯作者: 徐健，E-mail: ydukongjian@163.com 李京，E-mail: lijing@sdsmu.edu.cn

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Characteristics of human papilloma virus infection in female in Weifang from 2019 to 2023

Corresponding author: LI Jing, E-mail: lijing@sdsmu.edu.cn; XU Jian, E-mail: ydukongjian@163.com

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出版历程

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通讯作者:
徐健，E-mail: ydukongjian@163.com

李京，E-mail: lijing@sdsmu.edu.cn